{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T21:00:04Z","timestamp":1697576404260},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>Freely soluble and complexed plasma immunoglobulin A (IgA), IgG, IgM, C1q, C3, and factor B in 36 human immunodeficiency virus type I (HIV-1)-seronegative controls, 69 asymptomatic HIV+ subjects, and 117 individuals with symptomatic HIV-associated disease were characterized. Levels of free and complexed IgG and IgA, and to a lesser extent free C1q and complexed IgM, increased with HIV-1 infection. In stark contrast, both HIV+ groups showed three- to sixfold declines in complexed C3, C1q, and factor B levels. The asymptomatic HIV+ population showed declines in levels of C3-bound IgA, IgG2, and IgG4 complexes. The asymptomatic group showed reductions in C3-complexed IgM, IgA, IgG2, and IgG4 levels. HIV infection is associated with complement-deficient immune complexes.<\/jats:p>","DOI":"10.1128\/cdli.3.1.128-131.1996","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:36:25Z","timestamp":1578335785000},"page":"128-131","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Immunoglobulin and complement complexes in blood following infection with human immunodeficiency virus type 1"],"prefix":"10.1128","volume":"3","author":[{"given":"X X","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Biological Science and Technology, Nanchang University, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Wainberg","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, Nanchang University, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, Nanchang University, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B G","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, Nanchang University, People's Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Clinical Diagnostic Laboratory Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.3.1.128-131.1996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.3.1.128-131.1996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:07:18Z","timestamp":1645596438000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/cdli.3.1.128-131.1996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1128\/cdli.3.1.128-131.1996"],"URL":"https:\/\/doi.org\/10.1128\/cdli.3.1.128-131.1996","relation":{},"ISSN":["1071-412X","1098-6588"],"issn-type":[{"value":"1071-412X","type":"print"},{"value":"1098-6588","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1]]},"assertion":[{"value":"1996-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}