{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:54:50Z","timestamp":1761630890494},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p>We detected (1 --&gt; 3) beta-D-glucan (beta-glucan), which is one of the major components of the cyst wall of Pneumocystis carinii, in sera obtained from patients with P. carinii pneumonia (PCP). We confirmed that beta-glucan was detectable by a beta-glucan detection kit (G test; Seikagaku Corporation) in bronchoalveolar lavage fluids (BALFs). The mean concentration of beta-glucan in BALFs obtained from specific-pathogen-free nude mice infected with P. carinii (n = 7; mean, 2,631 [range, 1,031 to 9,095] pg\/ml) was significantly higher (P &lt; 0.001) than that in uninfected, specific-pathogen-free mice (n = 7; 6.5 [range, 4.0 to 8.3] pg\/ml). The mean level of beta-glucan in BALFs from PCP patients was significantly higher (P &lt; 0.05) than that in BALFs from patients with other lung diseases (7,268 [range, 1,355 to 15,500] pg\/ml [n = 4] versus 242.5 [17 to 615] pg\/ml [n = 4]). In sera from six of seven patients with PCP, significant levels of beta-glucan (494.1 [8.5 to 1,135] pg\/ml) were detected, while it was undetectable in patients with other lung diseases and in a control group. In five patients at follow-up, the level of beta-glucan decreased with clinical improvement. These results suggest that beta-glucan is detectable in sera from patients with PCP and it is a practical serological marker for monitoring of the disease during treatment.<\/jats:p>","DOI":"10.1128\/cdli.3.2.197-199.1996","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:36:39Z","timestamp":1578335799000},"page":"197-199","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":77,"title":["(1--&gt;3) beta-D-glucan as a quantitative serological marker for Pneumocystis carinii pneumonia"],"prefix":"10.1128","volume":"3","author":[{"given":"A","family":"Yasuoka","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan. yasuoka@ims.u-tokyo.ac.jp"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Tachikawa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan. yasuoka@ims.u-tokyo.ac.jp"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan. yasuoka@ims.u-tokyo.ac.jp"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan. yasuoka@ims.u-tokyo.ac.jp"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan. yasuoka@ims.u-tokyo.ac.jp"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Clinical Diagnostic Laboratory Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.3.2.197-199.1996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.3.2.197-199.1996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:25:06Z","timestamp":1645597506000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/cdli.3.2.197-199.1996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["10.1128\/cdli.3.2.197-199.1996"],"URL":"https:\/\/doi.org\/10.1128\/cdli.3.2.197-199.1996","relation":{},"ISSN":["1071-412X","1098-6588"],"issn-type":[{"value":"1071-412X","type":"print"},{"value":"1098-6588","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]},"assertion":[{"value":"1996-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}