{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:38:09Z","timestamp":1770719889623,"version":"3.49.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>Antigens from inactivated Mycobacterium tuberculosis H37Ra induce activation in a subpopulation of gamma\/delta (gamma\/delta) T lymphocytes in a manner that resembles that of superantigens from alpha\/beta T cells. After culture in vitro with H37Ra proteins, gamma\/delta T lymphocytes from patients with advanced clinical forms of active tuberculosis (ACF-TBC) display cytotoxic activity against homotypic target cells exposed to H37Ra. Cytotoxicity by gamma\/delta T lymphocytes from ACF-TBC patients occurs in a range similar to that observed in healthy subjects. Following activation, H37Ra-stimulated gamma\/delta T lymphocytes from healthy subjects did proliferate in the presence of exogenous recombinant human interleukin 2. However, under the same conditions, gamma\/delta T lymphocytes from ACF-TBC patients not only did not proliferate but died by apoptosis. These results suggest that in gamma\/delta T lymphocytes from patients with ACF-TBC, antigens from M. tuberculosis may induce cell activation that leads to apoptotic cell death.<\/jats:p>","DOI":"10.1128\/cdli.4.1.14-18.1997","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:38:51Z","timestamp":1578335931000},"page":"14-18","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Mycobacterium tuberculosis induces apoptosis in gamma\/delta T lymphocytes from patients with advanced clinical forms of active tuberculosis"],"prefix":"10.1128","volume":"4","author":[{"given":"R","family":"Duarte","sequence":"first","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Kindlel\u00e1n","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Carracedo","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"S\u00e1nchez-Guijo","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Clinical Diagnostic Laboratory Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.4.1.14-18.1997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.4.1.14-18.1997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:31:36Z","timestamp":1645597896000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/cdli.4.1.14-18.1997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["10.1128\/cdli.4.1.14-18.1997"],"URL":"https:\/\/doi.org\/10.1128\/cdli.4.1.14-18.1997","relation":{},"ISSN":["1071-412X","1098-6588"],"issn-type":[{"value":"1071-412X","type":"print"},{"value":"1098-6588","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1]]},"assertion":[{"value":"1997-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}