{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:25:13Z","timestamp":1759335913222},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1997,5,1]],"date-time":"1997-05-01T00:00:00Z","timestamp":862444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:p>Immunoglobulin M (IgM) and IgA responses in patients with acute Q fever were compared by enzyme-linked immunosorbent assay. An increase in both IgM and IgA was observed in paired sera from all 19 patients with acute Q fever, and both IgM and IgA levels showed good correlation with complement fixation test titers. Paired sera from 23 patients with infections other than Q fever were also tested. IgM levels were elevated in three of these patients, while IgA levels were elevated in three different patients (87% specificity for either IgM or IgA). As no patients in the disease control group showed elevated levels of both IgM and IgA, definition of a positive result as elevated levels of both IgM and IgA improved specificity to 100% without a decrease in sensitivity. This study indicates that detection of specific IgA is a useful adjunct to that of IgM in the diagnosis of acute Q fever.<\/jats:p>","DOI":"10.1128\/cdli.4.3.384-386.1997","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:39:36Z","timestamp":1578335976000},"page":"384-386","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Combined determination of Coxiella burnetii-specific immunoglobulin M (IgM) and IgA improves specificity in the diagnosis of acute Q fever"],"prefix":"10.1128","volume":"4","author":[{"given":"P","family":"Devine","sequence":"first","affiliation":[{"name":"Clinical Sciences, University of Queensland, Herston, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Doyle","sequence":"additional","affiliation":[{"name":"Clinical Sciences, University of Queensland, Herston, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Lambkin","sequence":"additional","affiliation":[{"name":"Clinical Sciences, University of Queensland, Herston, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Clinical Diagnostic Laboratory Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.4.3.384-386.1997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/cdli.4.3.384-386.1997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T07:02:23Z","timestamp":1645599743000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/cdli.4.3.384-386.1997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,5]]}},"alternative-id":["10.1128\/cdli.4.3.384-386.1997"],"URL":"https:\/\/doi.org\/10.1128\/cdli.4.3.384-386.1997","relation":{},"ISSN":["1071-412X","1098-6588"],"issn-type":[{"type":"print","value":"1071-412X"},{"type":"electronic","value":"1098-6588"}],"subject":[],"published":{"date-parts":[[1997,5]]},"assertion":[{"value":"1997-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}