{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:04:41Z","timestamp":1791097481007,"version":"4.1.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Well-proven mouse and rat models were used to show that polyclonal antisera to\n            <jats:italic>Pneumocystis carinii<\/jats:italic>\n            protect against\n            <jats:italic>P. carinii<\/jats:italic>\n            pneumonia. Antibodies were obtained from animals that were allowed to recover from severe\n            <jats:italic>P. carinii<\/jats:italic>\n            pneumonia after immunosuppression had been stopped and which then were given a booster injection of\n            <jats:italic>P. carinii<\/jats:italic>\n            from the same animal species. Mice immunosuppressed with corticosteroids or antibodies to L3T4\n            <jats:sup>+<\/jats:sup>\n            lymphocytes (which are comparable to CD4 cells of humans) and transtracheally inoculated with mouse\n            <jats:italic>P. carinii<\/jats:italic>\n            did not develop\n            <jats:italic>P. carinii<\/jats:italic>\n            pneumonia if they were passively immunized with antiserum, while mice immunosuppressed and inoculated by identical procedures but not given antibodies developed severe infections. Rats immunosuppressed with corticosteroids and inoculated with rat\n            <jats:italic>P. carinii<\/jats:italic>\n            had less severe infections if they were given rat anti-\n            <jats:italic>P. carinii<\/jats:italic>\n            antisera. The polyclonal antisera developed in mice provided greater protection for the mice than the polyclonal rat antisera did for the rats; however, the potencies and compositions of the antisera were not quantitated and probably differed. Since both rats and mice can be protected from\n            <jats:italic>P. carinii<\/jats:italic>\n            infections with polyclonal antisera, it may be possible to develop vaccines that will elicit protective antibodies in humans.\n          <\/jats:p>","DOI":"10.1128\/cdli.5.1.74-77.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T19:19:58Z","timestamp":1577819998000},"page":"74-77","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Antibody to\n            <i>Pneumocystis carinii<\/i>\n            Protects Rats and Mice from Developing Pneumonia"],"prefix":"10.1128","volume":"5","author":[{"given":"Marilyn S.","family":"Bartlett","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Angus","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->National Institutes of Health, Bethesda, Maryland2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Durant","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Hung","family":"Lee","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Pascale","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Smith","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.26.6.1100-1102.1988"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(90)90089-U"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.2.277"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(92)90036-S"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.1.5.511-516.1994"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.4.1315-1319.1993"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(89)90021-4"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1983.tb01083.x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.12.3258-3262.1992"},{"key":"e_1_3_1_11_2","first-page":"57","article-title":"Effect of T-cell transfer on Pneumocystis carinii infection in nude mice.","volume":"54","author":"Furuta T.","year":"1984","unstructured":"Furuta T. 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