{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:14:10Z","timestamp":1761560050455},"reference-count":16,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            HEp-2 cell-adherent\n            <jats:italic>Escherichia coli<\/jats:italic>\n            and the human immunodeficiency virus (HIV) itself have recently been incriminated as causes of chronic HIV-associated diarrhea. This study sought to determine the prevalence of these two agents among HIV-infected patients with diarrhea in an outpatient setting in the United States and to compare their prevalence to that of other commonly recognized enteropathogens known to be present in this population. HEp-2 cell-adherent\n            <jats:italic>E. coli<\/jats:italic>\n            was found in 20 of 83 (24.1%) patients with diarrhea. A diffuse pattern of adherence was the most common, found in 14 of 20 (70%) patients, followed by a localized adherence pattern (6 of 20; 30%). An intestinal secretory immune response against the p24 antigen of HIV was found in 9 of 34 (27.5%) patients with HIV-associated diarrhea. The following pathogens or products were also detected in lower frequencies:\n            <jats:italic>Cryptosporidium<\/jats:italic>\n            spp. (10.8%),\n            <jats:italic>Clostridium difficile<\/jats:italic>\n            toxin (8.8%), microsporidia (6%),\n            <jats:italic>Isospora belli<\/jats:italic>\n            (3.6%),\n            <jats:italic>Blastocystis hominis<\/jats:italic>\n            (2.4%),\n            <jats:italic>Giardia<\/jats:italic>\n            spp. (1.2%),\n            <jats:italic>Salmonella<\/jats:italic>\n            spp. (1.2%), and\n            <jats:italic>Mycobacterium<\/jats:italic>\n            spp. (1.2%). The role of HEp-2 cell-adherent\n            <jats:italic>E. coli<\/jats:italic>\n            and HIV enteric infections in patients with HIV-associated diarrhea deserves further study.\n          <\/jats:p>","DOI":"10.1128\/cdli.5.1.87-90.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T19:20:02Z","timestamp":1577820002000},"page":"87-90","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["HEp-2 Cell-Adherent\n            <i>Escherichia coli<\/i>\n            and Intestinal Secretory Immune Response to Human Immunodeficiency Virus (HIV) in Outpatients with HIV-Associated Diarrhea"],"prefix":"10.1128","volume":"5","author":[{"given":"John J.","family":"Mathewson","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Center for Infectious Diseases, The University of Texas School of Public Health and Medical School,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassam M.","family":"Salameh","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Center for Infectious Diseases, The University of Texas School of Public Health and Medical School,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert L.","family":"DuPont","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Center for Infectious Diseases, The University of Texas School of Public Health and Medical School,1 and"},{"name":"<!--label omitted: 2-->Department of Internal Medicine, St. Luke\u2019s Episcopal Hospital,2Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi D.","family":"Jiang","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Center for Infectious Diseases, The University of Texas School of Public Health and Medical School,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Nelson","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Center for Infectious Diseases, The University of Texas School of Public Health and Medical School,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Arduino","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Center for Infectious Diseases, The University of Texas School of Public Health and Medical School,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda A.","family":"Smith","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Center for Infectious Diseases, The University of Texas School of Public Health and Medical School,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Masozera","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Center for Infectious Diseases, The University of Texas School of Public Health and Medical School,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.4.726"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198908000-00005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/004947559202200102"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.5.979"},{"key":"e_1_3_2_6_2","first-page":"823","article-title":"Detection, localization, and quantitation of HIV-associated antigens in intestinal biopsies from patients with HIV.","volume":"139","author":"Kotler D. 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