{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:39:07Z","timestamp":1787585947593,"version":"build-2736575974"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In this study we have determined systemic and local antibody responses against different\n            <jats:italic>Helicobacter pylori<\/jats:italic>\n            antigens in\n            <jats:italic>H. pylori<\/jats:italic>\n            -infected and noninfected subjects. In addition, we studied whether differences in antibody responses between patients with duodenal ulcers and asymptomatic\n            <jats:italic>H. pylori<\/jats:italic>\n            carriers might explain the different outcomes of infection. Sera and in most instances gastric aspirates were collected from 19 duodenal ulcer patients, 15 asymptomatic\n            <jats:italic>H. pylori<\/jats:italic>\n            carriers, and 20 noninfected subjects and assayed for specific antibodies against different\n            <jats:italic>H. pylori<\/jats:italic>\n            antigens, i.e., whole membrane proteins (MP), lipopolysaccharides, flagellin, urease, the neuraminyllactose binding hemagglutinin HpaA, and a 26-kDa protein, by enzyme-linked immunosorbent assay. The\n            <jats:italic>H. pylori<\/jats:italic>\n            -infected subjects had significantly higher antibody titers against MP, flagellin, and urease in both sera and gastric aspirates compared with the noninfected subjects. Furthermore, the antibody titers against HpaA were significantly elevated in sera but not in gastric aspirates from the infected subjects. However, no differences in antibody titers against any of the tested antigens could be detected between the duodenal ulcer patients and the asymptomatic\n            <jats:italic>H. pylori<\/jats:italic>\n            carriers, either in sera or in gastric aspirates.\n          <\/jats:p>","DOI":"10.1128\/cdli.5.3.288-293.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T19:20:37Z","timestamp":1577820037000},"page":"288-293","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["Specific Antibodies in Sera and Gastric Aspirates of Symptomatic and Asymptomatic\n            <i>Helicobacter pylori<\/i>\n            -Infected Subjects"],"prefix":"10.1128","volume":"5","author":[{"given":"A.","family":"Mattsson","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Departments of Medical Microbiology and Immunology1 and of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tinnert","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments of Medical Microbiology and Immunology1 and of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hamlet","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments of Medical Microbiology and Immunology1 and of"},{"name":"<!--label omitted: 2-->Surgery,2 Go\u0308teborg University, Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lo\u0308nroth","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Surgery,2 Go\u0308teborg University, Go\u0308teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bo\u0308lin","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments of Medical Microbiology and Immunology1 and of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.-M.","family":"Svennerholm","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments of Medical Microbiology and Immunology1 and of"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00267382"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.30.17771"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90126-J"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.2.381-384.1995"},{"key":"e_1_3_2_6_2","first-page":"949","article-title":"Prevalence of CagA-bearing Helicobacter pylori strains detected by the anti-CagA assay in patients with peptic ulcer disease and in controls.","volume":"91","author":"Ching C. K.","year":"1996","unstructured":"Ching C. K. Wong B. C. Kwok E. Ong L. Covacci A. Lam S. K. Prevalence of CagA-bearing Helicobacter pylori strains detected by the anti-CagA assay in patients with peptic ulcer disease and in controls. Am. J. Gastroenterol. 91 1996 949 953","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90275-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90477-7"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38872-6"},{"key":"e_1_3_2_10_2","first-page":"1282","article-title":"Restriction fragment length polymorphism in the adhesin gene hpaA of Helicobacter pylori.","volume":"90","author":"Evans D. G.","year":"1995","unstructured":"Evans D. G. Evans D. J. Jr. Lampert H. C. Graham D. Y. Restriction fragment length polymorphism in the adhesin gene hpaA of Helicobacter pylori. Am. J. Gastroenterol. 90 1995 1282 1288","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.3.674-683.1993"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.5.2125-2127.1992"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529509096309"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529509101607"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.4.5.592-597.1997"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2508(94)90075-2"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.24.2.203-209.1986"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.57.6.1809-1815.1989"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.3.937-946.1991"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91119-8"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.1.161"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.12.5376-5380.1997"},{"key":"e_1_3_2_24_2","unstructured":"Lundstr\u00f6m A. et al. Unpublished data."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1995.tb00045.x"},{"key":"e_1_3_2_26_2","unstructured":"Mattsson A. M. Quiding-J\u00e4rbrink H. L\u00f6nroth A. Hamlet I. Ahlstedt and A.-M. Svennerholm. Antibody-secreting cells in the stomach of symptomatic and asymptomatic Helicobacter pylori infected subjects. Submitted for publication."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.12.3175-3180.1992"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.21.6049-6057.1995"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.2.505-513.1991"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(77)90043-4"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309098333"},{"key":"e_1_3_2_33_2","unstructured":"Sugiyama T. S. Furuyama T. Awakawa T. Kobayashi T. Yabana and A. Yachi. 1993. Local immune response in gastric mucosa to Helicobacter pylori infection with and without intestinal metaplasia. Eur. J. Gastroenterol. Hepatol. 5 (Suppl. 1) : 119\u2013122."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/149.6.884"},{"key":"e_1_3_2_35_2","unstructured":"Thoreson A.-C. et al. Unpublished data."},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1997.0158"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.5.1171"},{"key":"e_1_3_2_38_2","first-page":"83","article-title":"Bacterial lipopolysaccharide: extraction with phenol-water and further applications of the procedure.","volume":"5","author":"Westphal O.","year":"1965","unstructured":"Westphal O. Jann K. Bacterial lipopolysaccharide: extraction with phenol-water and further applications of the procedure. Methods Carbohydr. Chem. 5 1965 83 92","journal-title":"Methods Carbohydr. Chem."},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809091712"}],"container-title":["Clinical Diagnostic Laboratory Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.5.3.288-293.1998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.5.3.288-293.1998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T03:21:33Z","timestamp":1645586493000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CDLI.5.3.288-293.1998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1128\/CDLI.5.3.288-293.1998"],"URL":"https:\/\/doi.org\/10.1128\/cdli.5.3.288-293.1998","relation":{},"ISSN":["1071-412X","1098-6588"],"issn-type":[{"value":"1071-412X","type":"print"},{"value":"1098-6588","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"1997-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}