{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:11:00Z","timestamp":1791220260376,"version":"4.1.0"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We wished to determine the prevalence of immunoglobulin A (IgA) deficiency in patients with the chromosome 22q11.2 deletion syndrome. A total of 32 patients with the chromosome 22q11.2 deletion were examined for IgA deficiency. We report a 13% (\n            <jats:italic>n<\/jats:italic>\n            = 4) prevalence of IgA deficiency in patients with this syndrome. The odds ratio of IgA deficiency in this population is 14.20 (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.0001). This confirms the occurrence of significant humoral deficits in this predominantly cellular immunodeficiency.\n          <\/jats:p>","DOI":"10.1128\/cdli.5.3.415-417.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T19:20:48Z","timestamp":1577820048000},"page":"415-417","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":72,"title":["Increased Prevalence of Immunoglobulin A Deficiency in Patients with the Chromosome 22q11.2 Deletion Syndrome (DiGeorge Syndrome\/Velocardiofacial Syndrome)"],"prefix":"10.1128","volume":"5","author":[{"given":"Christopher A.","family":"Smith","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Immunologic and Infectious Diseases1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Driscoll","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Obstetrics and Gynecology, The University of Pennsylvania School of Medicine,2 Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly S.","family":"Emanuel","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Division of Human Genetics and Molecular Biology,3 The Children\u2019s Hospital of Philadelphia, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"McDonald-McGinn","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Division of Human Genetics and Molecular Biology,3 The Children\u2019s Hospital of Philadelphia, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine H.","family":"Zackai","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Division of Human Genetics and Molecular Biology,3 The Children\u2019s Hospital of Philadelphia, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Immunologic and Infectious Diseases1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80837-6"},{"key":"e_1_3_2_3_2","unstructured":"Buckley\nR. H.\nPrimary immunodeficiency diseases\nFundamental immunology\n3rd ed.\nPaul\nW. E.\n1993\n1353\n1374\nRaven Press\nNew York N.Y"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(75)80006-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/80.2.210"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80207-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70200-2"},{"key":"e_1_3_2_8_2","unstructured":"Cunningham-Rundles\nC.\nDiseases of the IgA system\nImmunologic disorders in infants and children. W. B.\nStiehm\nE. R.\n1996\n423\n442\nSaunders\nPhiladelphia Pa"},{"key":"e_1_3_2_9_2","first-page":"924","article-title":"A genetic etiology for DiGeorge syndrome: consistent deletions and microdeletions of 22q11.","volume":"50","author":"Driscoll D. A.","year":"1992","unstructured":"Driscoll D. A. Budarf M. L. Emanuel B. S. A genetic etiology for DiGeorge syndrome: consistent deletions and microdeletions of 22q11. Am. J. Hum. Genet. 50 1992 924 933","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_2_10_2","first-page":"A163","article-title":"Familial 22q11 deletions: phenotypic variability and determination of deletion boundaries by FISH.","volume":"57","author":"Driscoll D. A.","year":"1995","unstructured":"Driscoll D. A. Li M. Chien P. Capuano S. Zackai E. H. McDonald-McGinn D. M. Christensen K. M. Cuneo B. F. Saal H. M. Gold R. Spector E. B. Emanuel B. S. Budarf M. L. Familial 22q11 deletions: phenotypic variability and determination of deletion boundaries by FISH. Am. J. Hum. Genet. 57 1995 A163","journal-title":"Am. J. Hum. 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