{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:28:42Z","timestamp":1770910122659,"version":"3.50.1"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Seventy-three piglets were weaned at 1 week of age, randomly assigned to 10 groups (A to J), accommodated in stainless steel exposure chambers, and exposed continuously to a controlled environment containing aerosolized ovalbumin. The concentrations of ovalbumin dust were as follows (milligrams per cubic meter): A and F, 16.6; B and G, 8.4; C and H, 4.2; D and I, 2.1; E and J, 0. At weekly intervals, the pigs were bled via venipuncture and anesthetized for nasal lavage and tonsilar biopsies performed for subsequent bacteriologic analysis. At 2 weeks of age, the pigs in groups A to E were challenged with toxigenic\n            <jats:italic>Pasteurella multocida<\/jats:italic>\n            (10\n            <jats:sup>8<\/jats:sup>\n            CFU pig\n            <jats:sup>\u22121<\/jats:sup>\n            ), and at 6 weeks of age, the pigs were euthanatized. At postmortem, the extent of turbinate atrophy was assessed on the snout sections by using a morphometric index. Exposure to aerial ovalbumin resulted in a dose-dependent increase in serum antiovalbumin immunoglobulin G (IgG;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001) and serum antiovalbumin IgA (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Exposure also caused a significant increase in the numbers of\n            <jats:italic>P. multocida<\/jats:italic>\n            organisms isolated from the upper respiratory tract (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001) and a corresponding increase in turbinate atrophy, as judged by the morphometric index (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Concurrent challenge with\n            <jats:italic>P. multocida<\/jats:italic>\n            and ovalbumin resulted in a significant decrease in both the IgG and IgA responses to ovalbumin (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). These results show that ovalbumin exposure increases pig susceptibility to\n            <jats:italic>P. multocida<\/jats:italic>\n            colonization and that toxigenic\n            <jats:italic>P. multocida<\/jats:italic>\n            modifies the serum IgG and IgA responses to ovalbumin in the pig. Both of these effects may enhance the virulence of this respiratory pathogen and so influence the pathogenesis of atrophic rhinitis in pigs.\n          <\/jats:p>","DOI":"10.1128\/cdli.5.4.494-498.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T19:20:56Z","timestamp":1577820056000},"page":"494-498","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Ovalbumin Aerosol Exposure on Colonization of the Porcine Upper Airway by\n            <i>Pasteurella multocida<\/i>\n            and Effect of Colonization on Subsequent Immune Function"],"prefix":"10.1128","volume":"5","author":[{"given":"T. D. C.","family":"Hamilton","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->The Aerobiology Group, Division of Animal Health and Husbandry, Department of Clinical Veterinary Sciences, School of Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Roe","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->The Aerobiology Group, Division of Animal Health and Husbandry, Department of Clinical Veterinary Sciences, School of Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Hayes","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->The Aerobiology Group, Division of Animal Health and Husbandry, Department of Clinical Veterinary Sciences, School of Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. F.","family":"Webster","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->The Aerobiology Group, Division of Animal Health and Husbandry, Department of Clinical Veterinary Sciences, School of Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"291","article-title":"Die Immunit\u00e4tsparalyse bei Brucellosen.","volume":"122","author":"Alivisators G. P.","year":"1962","unstructured":"Alivisators G. P. Marketos N. Vava Z. Die Immunit\u00e4tsparalyse bei Brucellosen. Z. 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