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Based on such serologic tests, the prevalence of HTLV-1 infection is estimated to range from 0.016 to 0.1%. As a consequence of studies of patients with mycosis fungoides and some of their healthy relatives who are antibody negative but were found to carry the<jats:italic>tax<\/jats:italic>sequence of HTLV-1 in their lymphocytes and who had antibodies to the p40<jats:sup><jats:italic>tax<\/jats:italic><\/jats:sup>protein, a study was undertaken to determine the prevalence of the \u201c<jats:italic>tax<\/jats:italic>-only\u201d state in 250 healthy blood donors and other volunteers. Using PCR and Southern analysis for cell lysates and using Western blotting for plasmas, 8.6% of the blood donors proved to be<jats:italic>tax<\/jats:italic>sequence positive and antibody positive. Sequence analysis of specimens from 22 individuals proved that 20 of the sequences were homologous with that of HTLV-1 while 2 resembled the HTLV-2 sequence. The latter were obtained from volunteers of Indian origin. The possible clinical significance of the<jats:italic>tax<\/jats:italic>-only carrier state is discussed.<\/jats:p>","DOI":"10.1128\/cdli.5.6.831-835.1998","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T19:21:41Z","timestamp":1577820101000},"page":"831-835","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Human T-Cell Lymphotropic Virus Type 1 Tax among American Blood Donors"],"prefix":"10.1128","volume":"5","author":[{"given":"Dorothea","family":"Zucker-Franklin","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, New York University Medical Center, New York, New York 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bette A.","family":"Pancake","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medicine, New York University Medical Center, New York, New York 10016"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-1-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Buckle G. 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