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Significant deficiencies in the number of B cells in the blood, the concentrations of immunoglobulins in the serum, and the titers of antibodies to T-dependent and T-independent antigens resolved spontaneously by the age of 39 months in a sequence that duplicated the normal development of the B-cell lineage: blood B cells followed by immunoglobulin M (IgM), IgG, IgA, and specific IgG antibodies to T-independent antigens (pneumococcal polysaccharides). Because of the sequence of recovery, the disorder could have been confused with other defects in humoral immunity, depending on when in the course of disease immunologic studies were conducted. Investigations of X-chromosome polymorphisms suggested that the disorder was not X linked in that the mother appeared to have identical X chromosomes. An autosomal recessive disorder involving a gene that controls B-cell development and maturation seems more likely. In summary, this case appears to be a novel protracted delay in the development of the B-cell lineage, possibly due to an autosomal recessive genetic defect.<\/jats:p>","DOI":"10.1128\/cdli.6.2.161-167.1999","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T19:22:14Z","timestamp":1577820134000},"page":"161-167","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Immunodeficiency Due to a Unique Protracted Developmental Delay in the B-Cell Lineage"],"prefix":"10.1128","volume":"6","author":[{"given":"Armond S.","family":"Goldman","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Pediatrics,1"},{"name":"<!--label omitted: 2-->Microbiology and Immunology,2"},{"name":"<!--label omitted: 3-->Pathology,3 and"},{"name":"<!--label omitted: 4-->Human Biological Chemistry and Genetics4 of the University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen E.","family":"Miles","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pediatrics,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen E.","family":"Rudloff","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pediatrics,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly H.","family":"Palkowetz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pediatrics,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Frank C.","family":"Schmalstieg","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Pediatrics,1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199209000-00001"},{"key":"e_1_3_1_3_2","first-page":"1229","article-title":"Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation.","volume":"51","author":"Allen R. 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