{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:22:08Z","timestamp":1775121728207,"version":"3.50.1"},"reference-count":8,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Ten microbiological departments in Norway have participated in a multicenter evaluation of the following commercial tests for detection of Epstein-Barr virus (EBV)-specific and heterophile antibodies: CAPTIA Select viral capsid antigen (VCA)-M\/G\/EBNA (Centocor Inc.), Enzygnost anti-EBV\/immunoglobulin M (IgM) and IgG (Dade Behring), Vironostika EBV VCA IgM\/IgG\/EBNA enzyme-linked immunosorbent assay (ELISA) (Organon Teknika), SEROFLUOR immunofluorescence assay and EBV Combi-Test (Institute Virion Ltd.), anti-EBV recombinant IgM- and IgG-early antigen\/EBNA IgG ELISA (Biotest Diagnostics), EBV IgM\/IgG\/EBNA ELISA (Gull Laboratories), Paul-Bunnell-Davidsohn test (Sanofi Diagnostics Pasteur), Monosticon Dri-Dot (Organon Teknika), Avitex-IM (Omega Diagnostics Ltd.), Alexon Serascan infectious mononucleosis test (Alexon Biomedical Inc.), Clearview IM (Unipath Ltd.), and Cards\u00b1OS Mono (Pacific Biotech, Inc.). The test panel included sera from patients with primary EBV infection, immunocompromised patients with recent cytomegalovirus infection, healthy persons (blood donors), and EBV-seronegative persons. Among the tests for EBV-specific antibodies the sensitivity was good, with only small differences between the different assays. However, there was a greater variation in specificity, which varied between 100% (Enzygnost) and 86% (Biotest). Tests for detection of heterophile antibodies based on purified or selected antigen (Avitex, Alexon, Clearview IM, and Cards\u00b1OS Mono) were more sensitive than the Paul-Bunnell-Davidsohn and Monosticon tests.<\/jats:p>","DOI":"10.1128\/cdli.7.3.451-456.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"451-456","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":106,"title":["Evaluation of 12 Commercial Tests for Detection of Epstein-Barr Virus-Specific and Heterophile Antibodies"],"prefix":"10.1128","volume":"7","author":[{"given":"Anne-Lise","family":"Bruu","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Virology, National Institute of Public Health, Oslo,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reidar","family":"Hjetland","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Microbiology, Sogn and Fjordane Central Hospital, F\u00f8rde,2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Holter","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Institute of Microbiology, The National Hospital, Oslo,3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa","family":"Mortensen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Department of Microbiology, Nordland Central Hospital, Bod\u00f8,4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav","family":"Nat\u00e5s","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->Department of Microbiology, Rogaland Central Hospital, Stavanger,5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenche","family":"Petterson","sequence":"additional","affiliation":[{"name":"<!--label omitted: 6-->Laboratory of Microbiology, Vestfold Central Hospital, T\u00f8nsberg,6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Grete","family":"Skar","sequence":"additional","affiliation":[{"name":"<!--label omitted: 7-->Department of Microbiology, Ullev\u00e5l University Hospital, Oslo,7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tone","family":"Skarpaas","sequence":"additional","affiliation":[{"name":"<!--label omitted: 8-->Department of Microbiology, Vest-Agder Central Hospital, Kristiansand,8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trygve","family":"Tjade","sequence":"additional","affiliation":[{"name":"<!--label omitted: 9-->Department of Microbiology, Akershus Central Hospital, Nordbyhagen,9 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"\u212bsj\u00f8","sequence":"additional","affiliation":[{"name":"<!--label omitted: 10-->Department of Microbiology and Immunology, Haukeland University Hospital, Bergen,10 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199811)56:3<186::AID-JMV2>3.0.CO;2-3"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0197(96)00245-0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0888-0786(94)90017-5"},{"key":"e_1_3_1_5_2","first-page":"145","article-title":"Evaluation of ten commercial heterophile antibody tests for infectious mononucleosis.","volume":"93","author":"H\u00f8iby E. 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