{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:21:52Z","timestamp":1773847312134,"version":"3.50.1"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The iron chelator desferrioxamine (DFO) B is widely used in the therapy of patients with iron overload. As a side effect, DFO may favor the occurrence of fulminant\n            <jats:italic>Yersinia<\/jats:italic>\n            infections. Previous work from our laboratory showed that this might be due to a dual role of DFO: growth promotion of the pathogen and immunosuppression of the host. In this study, we sought to determine whether conjugation of DFO to hydroxyethyl starch (HES-DFO) may prevent exacerbation of\n            <jats:italic>Yersinia<\/jats:italic>\n            infection in mice. We found HES-DFO to promote neither growth of\n            <jats:italic>Yersinia enterocolitica<\/jats:italic>\n            nor mitogen-induced T-cell proliferation and gamma interferon production by T cells in vitro. Nevertheless, in vivo HES-DFO promoted growth of\n            <jats:italic>Y. enterocolitica<\/jats:italic>\n            possibly due to cleavage of HES and release of DFO. The pretreatment of mice with DFO resulted in death of all mice 2 to 5 days after application of a normally sublethal inoculum of\n            <jats:italic>Y. enterocolitica<\/jats:italic>\n            , while none of the mice pretreated with HES-DFO died within the first 7 days postinfection. However, some of the HES-DFO-treated mice died 8 to 14 days postinfection. Thus, due to the delayed in vivo effect HES-DFO failed to trigger\n            <jats:italic>Yersinia<\/jats:italic>\n            -induced septic shock, which accounts for early mortality in DFO-associated septicemia. Moreover, our data suggest that DFO needs to be taken up by host cells in order to exert its immunosuppressive action. These results strongly suggest that HES-DFO might be a favorable drug with fewer side effects than DFO in terms of DFO-promoted fulminant infections.\n          <\/jats:p>","DOI":"10.1128\/cdli.7.3.457-462.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"457-462","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Conjugation of Hydroxyethyl Starch to Desferrioxamine (DFO) Modulates the Dual Role of DFO in\n            <i>Yersinia enterocolitica<\/i>\n            Infection"],"prefix":"10.1128","volume":"7","author":[{"given":"So\u0308ren","family":"Schubert","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Max von Pettenkofer-Institut, Ludwig Maximilians-Universita\u0308t Mu\u0308nchen, 80336 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo B.","family":"Autenrieth","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Max von Pettenkofer-Institut, Ludwig Maximilians-Universita\u0308t Mu\u0308nchen, 80336 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1987.tb03163.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.6.2590-2599.1994"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.2.490"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00206117"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.3.562"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.3.1140-1149.1992"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.6.2585-2595.1993"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.51.4.509-518.1987"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0750-7658(05)80756-7"},{"key":"e_1_3_2_11_2","first-page":"416","article-title":"Survey on newly characterized iron uptake systems of Yersinia enterocolitica.","volume":"278","author":"Baumler A.","year":"1993","unstructured":"Baumler A. 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