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The serological response of 22 patients suffering from GAC, 31 patients with gastroduodenal ulcer, and 39 asymptomatic subjects was analyzed using immunoblotting performed with three\n            <jats:italic>H. pylori<\/jats:italic>\n            strains: strain ATCC 43579; strain B110, isolated from a patient with ulcers; and strain B225, isolated from a patient with GAC. In addition, the latex agglutination test Pyloriset Dry was used to analyze ambiguous sera.\n            <jats:italic>H. pylori<\/jats:italic>\n            seropositivity was 75% in the GAC group, 61.3% in the ulcer group, and 56.4% in the asymptomatic group. Anti-CagA antibodies were found more often in the GAC group (48.8%) and in the ulcer group (47.3%) than in the asymptomatic group (21.2%). These percentages depended on the strain used as an antigen: in the GAC group, the anti-CagA frequencies were 93.3, 40, and 13.3% with strains B225, B110, and ATCC 43579, respectively. Thus the presence of anti-CagA antibodies was increased in patients suffering from\n            <jats:italic>H. pylori<\/jats:italic>\n            -related GAC, in particular when the CagA antigen was from a GAC strain. These data suggest the existence of a CagA protein specifically expressed by\n            <jats:italic>H. pylori<\/jats:italic>\n            strains isolated from GAC patients.\n          <\/jats:p>","DOI":"10.1128\/cdli.7.3.463-467.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"463-467","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Antibody Response of Patients with\n            <i>Helicobacter pylori<\/i>\n            -Related Gastric Adenocarcinoma: Significance of Anti-CagA Antibodies"],"prefix":"10.1128","volume":"7","author":[{"given":"Christine","family":"Vaucher","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Bacte\u0301riologie, Faculte\u0301 de Me\u0301decine de Brest-Universite\u0301 de Bretagne occidentale,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blandine","family":"Janvier","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laboratoire de Microbiologie A, CHU La Mile\u0301trie et Faculte\u0301 de Me\u0301decine et de Pharmacie, 86000 Poitiers,2France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Baptiste","family":"Nousbaum","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Service de He\u0301pato-Gastro-Ente\u0301rologie, CHU La Cavale Blanche,3 29200 Brest, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Grignon","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laboratoire de Microbiologie A, CHU La Mile\u0301trie et Faculte\u0301 de Me\u0301decine et de Pharmacie, 86000 Poitiers,2France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Pezennec","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laboratoire de Microbiologie A, CHU La Mile\u0301trie et Faculte\u0301 de Me\u0301decine et de Pharmacie, 86000 Poitiers,2France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Robaszkiewicz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Service de He\u0301pato-Gastro-Ente\u0301rologie, CHU La Cavale Blanche,3 29200 Brest, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herve","family":"Gouerou","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Service de He\u0301pato-Gastro-Ente\u0301rologie, CHU La Cavale Blanche,3 29200 Brest, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Picard","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Bacte\u0301riologie, Faculte\u0301 de Me\u0301decine de Brest-Universite\u0301 de Bretagne occidentale,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Fauchere","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laboratoire de Microbiologie A, CHU La Mile\u0301trie et Faculte\u0301 de Me\u0301decine et de Pharmacie, 86000 Poitiers,2France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1998.00007.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.30.17771"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.4.931-936.1998"},{"key":"e_1_3_2_5_2","first-page":"21","article-title":"Infection by Helicobacter pylori is the major cause of duodenal ulcer.","volume":"24","author":"Baron J. 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