{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:35:45Z","timestamp":1789583745121,"version":"build-2803163510"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A longitudinal study was carried out in Madagascar, the most important focus of chromoblastomycosis (P. Esterre, A. Andriantsimahavandy, E. Ramarcel, and J. L. Pecarrere, Am. J. Trop. Med. Hyg. 55:45\u201347, 1996), to investigate natural immunity to this disease. Sequential blood samples were obtained before, during, and at the end of a successful therapeutic trial with terbinafine, a new antifungal drug. Using enzyme-linked immunosorbent assay and immunoblot methods, detailed analyses of antibody concentration and antigen mapping were conducted for 136 serum samples and tentatively correlated to epidemiological and pathobiological data. Two different cytoplasmic antigens, corresponding to the two fungal species involved (\n                    <jats:italic>Fonsecaea pedrosoi<\/jats:italic>\n                    and\n                    <jats:italic>Cladophialophora carrionii<\/jats:italic>\n                    ), were used to analyze the distribution of different classes of immunoglobulins. This was done with respect to the origin of the isolates, clinical and pathobiological. Although strong individual variations were noticed, some major antigens (one of 18.5 kDa specific for\n                    <jats:italic>F. pedrosoi<\/jats:italic>\n                    and two of 23.5 and 33 kDa, respectively, specific for\n                    <jats:italic>C. carrionii<\/jats:italic>\n                    ) corresponded to high antibody prevalence and concentration. As some antigenic components were also detected by immunoglobulin M (IgM) and IgA antibodies, the role that these specific antibodies could play in the immune response is discussed.\n                  <\/jats:p>","DOI":"10.1128\/cdli.7.3.497-500.2000","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:56:57Z","timestamp":1027749417000},"page":"497-500","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Humoral Immune Response in Chromoblastomycosis during and after Therapy"],"prefix":"10.1128","volume":"7","author":[{"given":"P.","family":"Esterre","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Parasitology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar,1 and"},{"name":"<!--label omitted: 2-->International Network of Pasteur Institutes, Institut Pasteur, F-75724 Paris ce\u0301dex 15, France2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jahevitra","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Parasitology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Andriantsimahavandy","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Parasitology Unit, Institut Pasteur de Madagascar, Antananarivo 101, Madagascar,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"30","article-title":"Apport de l'immunologie au diagnostic de la chromoblastomycose \u00e0 Madagascar.","volume":"3","author":"Andriantsimahavandy A.","year":"1993","unstructured":"Andriantsimahavandy A. Michel P. Rasolofonirina H. Roux J. Apport de l'immunologie au diagnostic de la chromoblastomycose \u00e0 Madagascar. J. Mycol. Med. 3 1993 30 36","journal-title":"J. Mycol. Med."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(99)80022-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.54.7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362176785190121"},{"key":"e_1_3_2_7_2","first-page":"65","article-title":"Utilisation de l'immunofluorescence indirecte dans la chromoblastomycose humaine et exp\u00e9rimentale \u00e0 Phialophora pedrosoi et Cladosporium carrionii. Etude pr\u00e9liminaire.","volume":"39","author":"Coulanges P.","year":"1970","unstructured":"Coulanges P. Mayoux A. Brygoo E. R. Rakoto M. Utilisation de l'immunofluorescence indirecte dans la chromoblastomycose humaine et exp\u00e9rimentale \u00e0 Phialophora pedrosoi et Cladosporium carrionii. Etude pr\u00e9liminaire. Arch. Inst. Pasteur Madagascar 39 1970 65 76","journal-title":"Arch. Inst. Pasteur Madagascar"},{"key":"e_1_3_2_8_2","first-page":"81","article-title":"Researchers use molecular immunology and technology to combat fungal pathogens.","volume":"62","author":"Dixon D. M.","year":"1996","unstructured":"Dixon D. M. Cox R. Cutler J. Deepe G. Researchers use molecular immunology and technology to combat fungal pathogens. ASM News 62 1996 81 84","journal-title":"ASM News"},{"key":"e_1_3_2_9_2","first-page":"1","article-title":"The increasing problem of fungal infections in the immunocompromised host.","volume":"6","author":"Dromer F.","year":"1996","unstructured":"Dromer F. Dupont B. The increasing problem of fungal infections in the immunocompromised host. J. Mycol. Med. 6 1996 1 6","journal-title":"J. Mycol. 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Inzan M. Ratsioharana A. Andriantsimahavandy C. Raharisolo E. Randrianiaina and P. Roig. A multicenter trial of terbinafine in patients with chromoblastomycosis: effects on clinical and biological criteria. J. Dermatol. Treat. 9: 529\u2013534.","DOI":"10.3109\/09546639809160714"},{"key":"e_1_3_2_17_2","first-page":"479","article-title":"Anti-neutrophilic cytoplasmic antibodies in patients with chromoblastomycosis.","volume":"14","author":"Galperin C.","year":"1996","unstructured":"Galperin C. Shoenfield Y. Bilburd B. Esterre P. Meroni L. Del Papa N. Halpern G. M. Andriantsimahavandy A. Gershwin M. E. Anti-neutrophilic cytoplasmic antibodies in patients with chromoblastomycosis. Clin. Exp. Rheumatol. 14 1996 479 483","journal-title":"Clin. Exp. 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