{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:54:54Z","timestamp":1758819294701},"reference-count":32,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The prevalence of celiac disease (CD) in Sweden is about 4 cases per 1,000 people. Screening for CD with serological tests indicates similar high prevalences in many other countries. Between 1 November 1992 and 30 April 1995, 133 children (9 months to 16.7 years of age) with suspected CD were studied. The predictive value (PV) of immunoglobulin A antigliadin antibodies (IgA-AGA) in the serum as assayed with two new commercial automated immunoassays\u2014the Pharmacia CAP System Gliadin IgA FEIA (CAP) and the UNICAP-100 (UNICAP)\u2014and with three \u201cin-house\u201d methods was evaluated using assessment of the small intestinal mucosa morphology as the \u201cgold standard.\u201d All serum samples were analyzed for total serum IgA. At presentation the diagnostic sensitivities and specificities of the different tests varied from 0.72 to 0.88 and 0.67 to 0.87, respectively. All methods showed a higher sensitivity for CD in younger children. The area under each assay's receiver operating characteristic curve was calculated and varied between 0.82 and 0.89. The positive and negative PVs for the CAP and UNICAP, which were assays with a high sensitivity and a high specificity, respectively, were estimated. In the clinically selected population (prevalence of CD, 1 in 3) the positive PV was about 55%, and in the general population (prevalence, 1 in 250) it was about 1%. The negative PVs for both CAP and UNICAP were close to 100%; thus, when the AGA test was negative, the risk for CD was small. Interestingly, five children had serum IgA levels below the detection limit (&lt;0.07 g\/liter) when on a gluten-free diet, whereas they had normal levels at the time of the first biopsy. In conclusion, the automated immunoassays\u2014based on ImmunoCAP technology\u2014for analysis of IgA-AGA had a reliability comparable to that of the in-house methods.<\/jats:p>","DOI":"10.1128\/cdli.8.3.564-570.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"564-570","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["New Automated Immunoassay Measuring Immunoglobulin A Antigliadin Antibodies for Prediction of Celiac Disease in Childhood"],"prefix":"10.1128","volume":"8","author":[{"given":"E.","family":"Grodzinsky","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Divisions of Clinical Immunology1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ivarsson","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Departments of Clinical Sciences, Paediatrics,2"},{"name":"<!--label omitted: 3-->Public Health and Clinical Medicine, Epidemiology,3 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Juto","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Clinical Microbiology, Virology,4 University Hospital of Northern Sweden, Ume\u00e5, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Olce\u0301n","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->Department of Clinical Microbiology and Immunology, O\u0308rebro Medical Centre Hospital,O\u0308rebro,5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Fa\u0308lth-Magnusson","sequence":"additional","affiliation":[{"name":"<!--label omitted: 6-->Paediatrics,6 Department of Health and Environment, University Hospital, Linko\u0308ping,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. A\u030a.","family":"Persson","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Public Health and Clinical Medicine, Epidemiology,3 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Hernell","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Departments of Clinical Sciences, Paediatrics,2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"236","article-title":"The small intestine in dermatitis herpetiformis","author":"Alexander J. O.","year":"1975","unstructured":"Alexander J. O. The small intestine in dermatitis herpetiformis Major problems in pathology Alexander J. O. IV. Dermatitis herpetiformis 1975 236 280 W. B. 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