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The incidence of CD in various autoimmune disorders is increased 10- to 30-fold in comparison to the general population, although in many cases CD is clinically asymptomatic or silent. The identification of such cases with CD is important since it may help in the control of type I diabetes or endocrine functions in general, as well as in the prevention of long-term complications of CD, such as lymphoma. It is believed that CD may predispose an individual to other autoimmune disorders such as type I diabetes, autoimmune thyroid, and other endocrine diseases and that gluten may be a possible trigger. The onset of type I diabetes at an early age in patients with CD, compared to non-CD, and the prevention or delay in onset of diabetes by gluten-free diet in genetically predisposed individuals substantiates this antigen trigger hypothesis. Early identification of CD patients in highly susceptible population may result in the treatment of subclinical CD and improved control of associated disorders.<\/jats:p>","DOI":"10.1128\/cdli.8.4.678-685.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"678-685","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":63,"title":["Celiac Disease-Associated Autoimmune Endocrinopathies"],"prefix":"10.1128","volume":"8","author":[{"given":"Vijay","family":"Kumar","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->IMMCO Diagnostics, Inc.,1 and"},{"name":"<!--label omitted: 2-->Departments of Microbiology and Dermatology, University at Buffalo, SUNY,2Buffalo, New York, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Rajadhyaksha","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->IMMCO Diagnostics, Inc.,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobo","family":"Wortsman","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Internal Medicine, School of Medicine, Southern Illinois University, Springfield, Illinois3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199801)15:1<38::AID-DIA520>3.0.CO;2-L"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(88)90139-0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)30018-2"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2825(1996)10:6<451::AID-JCLA24>3.0.CO;2-V"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(21)00148-4"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1999.0303"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.4.4682"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","unstructured":"Beutner E. 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