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The extracellular polysaccharide was produced under aerobic conditions in a medium containing olive mill wastewaters (80% [vol\/vol]). This exopolymer had a low level of acute toxicity when it is administered to BALB\/c mice by the intraperitoneal route. Interesting immunomodulatory effects were detected when mice were given 10 mg of exopolysaccharide per kg of body weight; the proliferative responses of splenocytes to B-cell and T-cell mitogens were suppressed, the in vitro levels of production of gamma interferon and granulocyte-macrophage colony-stimulating factor by unstimulated and lipopolysaccharide-stimulated splenocytes were enhanced, and the levels of resistance to the intracellular pathogen<jats:italic>Listeria monocytogenes<\/jats:italic>was increased in mice. Also, the exopolysaccharide was able to induce lymphocyte proliferation in vitro. We conclude that<jats:italic>P. jamilae<\/jats:italic>produces an exopolysaccharide with interesting immunomodulatory properties.<\/jats:p>","DOI":"10.1128\/cdli.8.4.706-710.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"706-710","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Biological Response Modifier Activity of an Exopolysaccharide from<i>Paenibacillus jamilae<\/i>CP-7"],"prefix":"10.1128","volume":"8","author":[{"given":"Alfonso","family":"Ruiz-Bravo","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Jimenez-Valera","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Encarnacion","family":"Moreno","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Guerra","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ramos-Cormenzana","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Microbiology, Faculty of Pharmacy, University of Granada, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Aguilera M. 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