{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:58:34Z","timestamp":1770472714641,"version":"3.49.0"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In this study, the effects of orally administered viable<jats:italic>Lactobacillus casei<\/jats:italic>Shirota strain YIT9029 on the immunity parameters of Wistar and Brown Norway rats were examined. For this purpose, we used the<jats:italic>Trichinella spiralis<\/jats:italic>host resistance model. Two weeks before and during<jats:italic>T. spiralis<\/jats:italic>infection, rats were fed 10<jats:sup>9<\/jats:sup>viable<jats:italic>L. casei<\/jats:italic>bacteria 5 days per week. The<jats:italic>T. spiralis<\/jats:italic>-specific delayed-type hypersensitivity (DTH) response was significantly enhanced in both Wistar and Brown Norway rats given<jats:italic>L. casei<\/jats:italic>. In both rat strains fed<jats:italic>L. casei<\/jats:italic>, serum<jats:italic>T. spiralis<\/jats:italic>-specific immunoglobulin G2b (IgG2b) concentrations were also significantly increased. In the model, no significant effects of<jats:italic>L. casei<\/jats:italic>on larval counts or inflammatory reactions in the tongue musculature, body weights, or lymphoid organ weights were observed. Serum specific antibody responses, other than IgG2b, were not changed by feeding of<jats:italic>L. casei<\/jats:italic>. In contrast to<jats:italic>L. casei<\/jats:italic>, it was shown that orally administered<jats:italic>Bifidobacterium breve<\/jats:italic>or<jats:italic>Bifidobacterium bifidum<\/jats:italic>had no influence on the measured infection and immunity indices in the rat infection model. Since the rat DTH response is considered to be a manifestation of Th1 cell-mediated immunity and the IgG2b isotype has been associated with Th1 activity, it was concluded that Th1 cells could play an active role in the immunomodulatory effects of orally administered<jats:italic>L. casei<\/jats:italic>. Furthermore, our data do not indicate that the effect of oral supplementation with<jats:italic>L. casei<\/jats:italic>is dependent on the genetic background of the host.<\/jats:p>","DOI":"10.1128\/cdli.8.4.762-767.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:55:30Z","timestamp":1027763730000},"page":"762-767","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":29,"title":["Enhanced Antigen-Specific Delayed-Type Hypersensitivity and Immunoglobulin G2b Responses after Oral Administration of Viable<i>Lactobacillus casei<\/i>YIT9029 in Wistar and Brown Norway Rats"],"prefix":"10.1128","volume":"8","author":[{"given":"R.","family":"de Waard","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of the Science of Food of Animal Origin1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Garssen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, Bilthoven,2 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Snel","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of the Science of Food of Animal Origin1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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