{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:25:47Z","timestamp":1760264747241},"reference-count":26,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Diagn Lab Immunol"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is related to<jats:italic>Helicobacter pylori<\/jats:italic>infection. Specifically, it has been pointed out that pathogenesis of MALT lymphoma involves the 60-kDa heat shock protein (hsp60). To investigate humoral immune responses to the<jats:italic>H. pylori<\/jats:italic>hsp60 in patients with gastroduodenal diseases and patients with MALT lymphoma, the hsp60 of<jats:italic>H. pylori<\/jats:italic>was expressed with a glutathione<jats:italic>S<\/jats:italic>-transferase fusion protein and was purified (recombinant hsp60). Sera were obtained from<jats:italic>H. pylori<\/jats:italic>-positive patients with gastroduodenal diseases (MALT lymphoma,<jats:italic>n<\/jats:italic>= 13; gastric ulcer,<jats:italic>n<\/jats:italic>= 20; duodenal ulcer,<jats:italic>n<\/jats:italic>= 20; gastritis,<jats:italic>n<\/jats:italic>= 20) and from<jats:italic>H. pylori<\/jats:italic>-negative healthy volunteers (<jats:italic>n<\/jats:italic>= 9). Sera from patients with MALT lymphoma were also obtained at two times: before and after eradication therapy. Antibodies to hsp60 and<jats:italic>H. pylori<\/jats:italic>were assessed by enzyme-linked immunosorbent assay. The levels of immunoglobulin G (IgG) antibodies to the hsp60 of<jats:italic>H. pylori<\/jats:italic>-positive patients with gastroduodenal diseases were significantly elevated compared to those in the controls. The levels of IgG1 antibodies to hsp60 were elevated and correlated with the levels of anti-<jats:italic>H. pylori<\/jats:italic>antibodies in patients with MALT lymphoma. Humarol immunity against hsp60 may be important and relevant to gastroduodenal diseases induced by<jats:italic>H. pylori<\/jats:italic>infection.<\/jats:p>","DOI":"10.1128\/cdli.8.6.1056-1059.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:56:57Z","timestamp":1027763817000},"page":"1056-1059","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Immunoglobulin G1 Antibody Response to<i>Helicobacter pylori<\/i>Heat Shock Protein 60 Is Closely Associated with Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma"],"prefix":"10.1128","volume":"8","author":[{"given":"E.","family":"Ishii","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Bacteriology, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Yokota","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Bacteriology, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Gastroenterology, Hokkaido University Graduate School of Medicine, N15, W7, Kita-ku, Sapporo, 060-0815,2 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Fujinaga","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Bacteriology, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ayada","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Bacteriology, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Hokari","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Gastroenterology, Hokkaido University Graduate School of Medicine, N15, W7, Kita-ku, Sapporo, 060-0815,2 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Microbiology, Jichi Medical School, 3311-1 Yakushiji Minamikouch-cho Kawauch-Gun, 329-0498,3 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hirai","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Microbiology, Jichi Medical School, 3311-1 Yakushiji Minamikouch-cho Kawauch-Gun, 329-0498,3 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Asaka","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Gastroenterology, Hokkaido University Graduate School of Medicine, N15, W7, Kita-ku, Sapporo, 060-0815,2 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Oguma","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Bacteriology, Okayama University Medical School, 2-5-1 Shikata-cho Okayama, 700-8558,1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00628.x"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70223-3"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64722-0"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00608.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209165432"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5791"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50054-0"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.1.41"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.4.720"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70028-3"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.10.1659"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2825(1996)10:2<74::AID-JCLA3>3.0.CO;2-L"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.7.1710-1714.1997"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.1.20"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.5.396"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.6.2705-2712.1998"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.4.1806-1814.2000"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178679"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.4.944-948.1998"},{"key":"e_1_3_1_22_2","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.4049\/jimmunol.160.5.2401","article-title":"Activation of IL-9 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells.","volume":"160","author":"Sharma S. A.","year":"1998","unstructured":"Sharma S. A. Tummuru M. K. Blaser M. J. Kerr L. D. Activation of IL-9 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells. J. Immunol. 160 1998 2401 2407","journal-title":"J. Immunol."},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.11.5543-5546.1998"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70365-8"},{"key":"e_1_3_1_25_2","first-page":"A40","article-title":"Study of CD40 ligand expression by antigen stimulation with H. pylori-HSP60.","volume":"47","author":"Yamasaki R.","year":"2000","unstructured":"Yamasaki R. Kobayashi K. Yokota K. Takada S. Ishii E. Okada H. Yoshino T. Oguma K. Akagi T. Study of CD40 ligand expression by antigen stimulation with H. pylori-HSP60. Gut 47 (Suppl.) 2000 A40 A41","journal-title":"Gut"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.7.4.574-577.2000"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.1.19"}],"container-title":["Clinical Diagnostic Laboratory Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.8.6.1056-1059.2001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.8.6.1056-1059.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T14:57:48Z","timestamp":1682261868000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CDLI.8.6.1056-1059.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["10.1128\/CDLI.8.6.1056-1059.2001"],"URL":"https:\/\/doi.org\/10.1128\/cdli.8.6.1056-1059.2001","relation":{},"ISSN":["1071-412X","1098-6588"],"issn-type":[{"value":"1071-412X","type":"print"},{"value":"1098-6588","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11]]},"assertion":[{"value":"2001-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}