{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:51:48Z","timestamp":1785232308019,"version":"3.55.0"},"reference-count":68,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Associations of<jats:italic>Helicobacter pylori<\/jats:italic>genotypes with disease differ between Western countries and Asia. Therefore, we directly compared histopathological and in vitro responses to clinical isolates with similar genotypes. Sixty-three<jats:italic>cagA<\/jats:italic><jats:sup>+<\/jats:sup><jats:italic>vacA<\/jats:italic>s1\/m1<jats:italic>H. pylori<\/jats:italic>isolates (United States,<jats:italic>n<\/jats:italic>= 24; Japan,<jats:italic>n<\/jats:italic>= 39) and eight<jats:italic>cagA<\/jats:italic>-negative<jats:italic>vacA<\/jats:italic>s2\/m2 strains were incubated with AGS cells, and supernatants were assayed for interleukin-8 (IL-8) and for DNA fragmentation. CagA tyrosine phosphorylation in AGS cells and the sequence of the putative HP0638 (<jats:italic>oipA<\/jats:italic>) signal sequence region were determined for 22 representative strains. HP0638 and\/or<jats:italic>cag<\/jats:italic>island mutant strains were created and examined in IL-8 and CagA tyrosine phosphorylation assays. Levels of IL-8 induction and DNA fragmentation were similar in the U.S. and Japanese<jats:italic>cagA<\/jats:italic><jats:sup>+<\/jats:sup><jats:italic>vacA<\/jats:italic>s1\/m1 isolates. All 10 of the isolates with the highest IL-8 induction and 8 of the 10 isolates with the lowest IL-8 induction had an in-frame<jats:italic>oipA<\/jats:italic>open reading frame, and all 10 of the isolates with the highest IL-8 induction and 7 of the 10 isolates with the lowest IL-8 induction induced CagA tyrosine phosphorylation in AGS cells. Eight isolates from gastric ulcer patients induced significantly more apoptosis in vitro, and more severe gastritis and atrophy in vivo, than other Japanese isolates. Disruption of HP0638 did not affect IL-8 induction or CagA tyrosine phosphorylation. Thus,<jats:italic>H. pylori cagA<\/jats:italic><jats:sup>+<\/jats:sup><jats:italic>vacA<\/jats:italic>s1\/m1 isolates from the United States and Japan induce similar IL-8 and apoptosis levels. Inactivation of HP0638 does not alter epithelial responses mediated by the<jats:italic>cag<\/jats:italic>island in vitro. Assessment of apoptosis in vitro identified a group of<jats:italic>H. pylori<\/jats:italic>isolates that induce more severe gastric inflammation and atrophy.<\/jats:p>","DOI":"10.1128\/cdli.9.1.167-175.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T10:03:59Z","timestamp":1027764239000},"page":"167-175","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Host Cell Responses to Genotypically Similar<i>Helicobacter pylori<\/i>Isolates from United States and Japan"],"prefix":"10.1128","volume":"9","author":[{"given":"Takafumi","family":"Ando","sequence":"first","affiliation":[{"name":"Department of Medicine, New York University School of Medicine"},{"name":"Department of Medicine, Vanderbilt University School of Medicine"},{"name":"First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan"},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee"},{"name":"Department of Veterans Affairs Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Richard M.","family":"Peek","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University School of Medicine"},{"name":"Department of Medicine, Vanderbilt University School of Medicine"},{"name":"First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan"},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee"},{"name":"Department of Veterans Affairs Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Chan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University School of Medicine"},{"name":"Department of Medicine, Vanderbilt University School of Medicine"},{"name":"First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan"},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee"},{"name":"Department of Veterans Affairs Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University School of Medicine"},{"name":"Department of Medicine, Vanderbilt University School of Medicine"},{"name":"First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan"},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee"},{"name":"Department of Veterans Affairs Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Kusugami","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University School of Medicine"},{"name":"Department of Medicine, Vanderbilt University School of Medicine"},{"name":"First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan"},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee"},{"name":"Department of Veterans Affairs Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Blaser","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University School of Medicine"},{"name":"Department of Medicine, Vanderbilt University School of Medicine"},{"name":"First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan"},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee"},{"name":"Department of Veterans Affairs Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1046\/j.1365-2958.1999.01382.x","volume":"32","year":"1999","unstructured":"Achtman, M., T. Azuma, D. E. Berg, Y. Ito, G. Morelli, Z. J. Pan, S. Suerbaum, S. A. Thompson, A. van der Ende, and L. J. van Doorn. 1999. Recombination and clonal groupings within Helicobacter pylori from different geographical regions. Mol. Microbiol.32:459\u2013470.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5577-5588.2001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2958.1998.00770.x","volume":"28","year":"1998","unstructured":"Akopyants, N. S., S. W. Clifton, D. Kersulyte, J. E. Crabtree, B. E. Youree, C. A. Reece, N. O. Bukanov, E. S. Drazek, B. A. Roe, and D. E. Berg. 1998. Analyses of the cag pathogenicity island of Helicobacter pylori.Mol. Microbiol.28:37\u201353.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/16495","volume":"397","year":"1999","unstructured":"Alm, R. A., L. S. Ling, D. T. Moir, B. L. King, E. D. Brown, P. C. Doig, D. R. Smith, B. Noonan, B. C. Guild, B. L. deJonge, G. Carmel, P. J. Tummino, A. Caruso, M. Uria-Nickelsen, D. M. Mills, C. Ives, R. Gibson, D. Merberg, S. D. Mills, Q. Jiang, D. E. Taylor, G. F. Vovis, and T. J. Trust. 1999. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature397:176\u2013180.","journal-title":"Nature"},{"key":"e_1_3_2_6_2","first-page":"1150","volume":"91","year":"1996","unstructured":"Ando, T., K. Kusugami, M. Ohsuga, M. Shinoda, M. Sakakibara, H. Saito, A. Fukatsu, S. Ichiyama, and M. Ohta. 1996. Interleukin-8 activity correlates with histological severity in Helicobacter pylori-associated antral gastritis. Am. J. Gastroenterol.91:1150\u20131156.","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.7.5.803-809.2000"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1136\/gut.40.6.701","volume":"40","year":"1997","unstructured":"Atherton, J. C. 1997. The clinical relevance of strain types of Helicobacter pylori. Gut40:701\u2013703.","journal-title":"Gut"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/oxfordjournals.bmb.a011662","volume":"54","year":"1998","unstructured":"Atherton, J. C. 1998. H. pylori virulence factors. Br. Med. Bull.54:105\u2013120.","journal-title":"Br. Med. Bull."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.30.17771"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s002849900447","volume":"39","year":"1999","unstructured":"Atherton, J. C., P. M. Sharp, T. L. Cover, G. Gonzalez-Valencia, R. M. Peek, S. A. Thompson, C. J. Hawkey, and M. J. Blaser. 1999. Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination. Curr. Microbiol.39:211\u2013218.","journal-title":"Curr. Microbiol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0016-5085(97)70223-3","volume":"112","year":"1997","unstructured":"Atherton, J. C., R. M. Peek, K. T. Tham, T. L. Cover, and M. J. Blaser. 1997. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.Gastroenterology112:92\u201399.","journal-title":"Gastroenterology"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0923-2508(00)00139-X","volume":"151","year":"2000","unstructured":"Audibert, C., B. Janvier, B. Grignon, L. Salaun, C. Burucoa, J. C. Lecron, and J. L. Fauchere. 2000. Correlation between IL-8 induction, cagA status and vacA genotypes in 153 French Helicobacter pylori isolates. Res. Microbiol.151:191\u2013200.","journal-title":"Res. Microbiol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1625-1629.2001"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1086\/314785","volume":"179","year":"1999","unstructured":"Blaser, M. J. 1999. The changing relationships of Helicobacter pylori and humans: implications for health and disease. J. Infect. Dis.179:1523\u20131530.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"14648","DOI":"10.1073\/pnas.93.25.14648","volume":"93","year":"1996","unstructured":"Censini, S., C. Lange, Z. Xiang, J. E. Crabtree, P. Ghiara, M. Borodovsky, R. Rappuoli, and A. Covacci. 1996. cag, a pathogenicity island of Helicobacter pylori, encodes type I specific and disease-associated virulence factors. Proc. Natl. Acad. Sci. USA93:14648\u201314653.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.90.12.5791","volume":"90","year":"1993","unstructured":"Covacci, A., S. Censini, M. Bugnoli, R. Petracca, D. Burroni, G. Macchia, A. Massone, E. Papini, Z. Xiang, N. Figura, and R. Rappuoli. 1993. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc. Natl. Acad. Sci. USA90:5791\u20135795.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.3.603-610.1990"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.6.1496-1500.1995"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/jcp.52.9.653","volume":"52","year":"1999","unstructured":"Crabtree, J. E., D. Kersulyte, S. D. Li, I. J. Lindley, and D. E. Berg. 1999. Modulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by cag PAI encoded VirD4 homologue. J. Clin. Pathol.52:653\u2013657.","journal-title":"J. Clin. Pathol."},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1136\/jcp.47.10.945","volume":"47","year":"1994","unstructured":"Crabtree, J. E., S. M. Farmery, I. J. Lindley, N. Figura, P. Peichl, and D. S. Tompkins. 1994. CagA\/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines. J. Clin. Pathol.47:945\u2013950.","journal-title":"J. Clin. Pathol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gut.33.8.1020","volume":"33","year":"1992","unstructured":"Craig, P. M., M. C. Territo, W. E. Karnes, and J. H. Walsh. 1992. Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils. Gut33:1020\u20131023.","journal-title":"Gut"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0016-5085(95)90009-8","volume":"108","year":"1995","unstructured":"Crowe, S. E., L. Alvarez, M. Dytoc, R. H. Hunt, M. Muller, P. Sherman, J. Patel, Y. Jin, and P. B. Ernst. 1995. Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro. Gastroenterology108:65\u201374.","journal-title":"Gastroenterology"},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/35006081","volume":"404","year":"2000","unstructured":"El-Omar, E. M., M. Carrington, W. H. Chow, K. E. McColl, J. H. Bream, H. A. Young, J. Herrera, J. Lissowska, C. C. Yuan, N. Rothman, G. Lanyon, M. Martin, J. F. Fraumeni, and C. S. Rabkin. 2000. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature404:398\u2013402.","journal-title":"Nature"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.micro.54.1.615","volume":"54","year":"2000","unstructured":"Ernst, P. B., and B. D. Gold. 2000. The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Annu. Rev. Microbiol.54:615\u2013640.","journal-title":"Annu. Rev. Microbiol."},{"key":"e_1_3_2_26_2","first-page":"73","volume":"123","year":"2000","unstructured":"Hansen, P. S., P. H. Madsen, S. B. Petersen, and H. Nielsen. 2000. Inflammatory activation of neutrophils by Helicobacter pylori; a mechanism insensitive to pertussis toxin. Clin. Exp. Immunol.123:73\u201380.","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_3_2_27_2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1172\/JCI11450","volume":"107","year":"2001","unstructured":"Israel, D. A., N. Salama, C. N. Arnold, S. F. Moss, T. Ando, H. P. Wirth, K. T. Tham, M. Camorlinga, M. J. Blaser, S. Falkow, and R. M. Peek. 2001. Helicobacter pylori strains associated with differential gastric cancer risks reconstitute human pathologic responses in experimental models of carcinogenesis. J. Clin. Investig.107:611\u2013620.","journal-title":"J. Clin. Investig."},{"key":"e_1_3_2_28_2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1086\/314435","volume":"178","year":"1998","unstructured":"Ito, Y., T. Azuma, S. Ito, H. Suto, H. Miyaji, Y. Yamazaki, Y. Kohli, and M. Kuriyama. 1998. Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori. J. Infect. Dis.178:1391\u20131398.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_29_2","first-page":"1695","volume":"151","year":"1997","unstructured":"Jones, N. L., P. T. Shannon, E. Cutz, H. Yeger, and P. M. Sherman. 1997. Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection. Am. J. Pathol.151:1695\u20131703.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_30_2","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1002\/1097-0142(19950615)75:12<2789::AID-CNCR2820751202>3.0.CO;2-4","volume":"75","year":"1995","unstructured":"Kikuchi, S., O. Wada, T. Nakajima, T. Nishi, O. Kobayashi, T. Konishi, and Y. Inaba. 1995. Serum anti-Helicobacter pylori antibody and gastric carcinoma among young adults. Research Group on Prevention of Gastric Carcinoma among Young Adults. Cancer75:2789\u20132793.","journal-title":"Cancer"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.9.3491-3496.1996"},{"key":"e_1_3_2_32_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","volume":"64","year":"1965","unstructured":"Lauren, P. 1965. The two histological main types of gastric carcinoma. An attempt at a histo-clinical classification. Acta Pathol. Microbiol. Scand.64:31\u201349.","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.3893-3899.1999"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/gut.44.3.336","volume":"44","year":"1999","unstructured":"Maeda, S., H. Yoshida, T. Ikenoue, K. Ogura, F. Kanai, N. Kato, Y. Shiratori, and M. Omata. 1999. Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates. Gut44:336\u2013341.","journal-title":"Gut"},{"key":"e_1_3_2_35_2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/gut.42.3.338","volume":"42","year":"1998","unstructured":"Maeda, S., K. Ogura, H. Yoshida, F. Kanai, T. Ikenoue, N. Kato, Y. Shiratori, and M. Omata. 1998. Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan. Gut42:338\u2013343.","journal-title":"Gut"},{"key":"e_1_3_2_36_2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.175.2.517","volume":"175","year":"1992","unstructured":"Mai, U. E., G. I. Perez-Perez, J. B. Allen, S. M. Wahl, M. J. Blaser, and P. D. Smith. 1992. Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa. J. Exp. Med.175:517\u2013525.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_37_2","first-page":"3238","volume":"56","year":"1996","unstructured":"Mannick, E. E., L. E. Bravo, G. Zarama, J. L. Realpe, X. J. Zhang, B. Ruiz, E. T. Fontham, R. Mera, M. J. Miller, and P. Correa. 1996. Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants. Cancer Res.56:3238\u20133243.","journal-title":"Cancer Res."},{"key":"e_1_3_2_38_2","first-page":"1406","volume":"61","year":"2001","unstructured":"Moss, S. F., E. M. Sordillo, A. M. Abdalla, V. Makarov, Z. Hanzely, G. I. Perez-Perez, M. J. Blaser, and P. R. Holt. 2001. Increased gastric epithelial cell apoptosis associated with colonization with cagA+Helicobacter pylori strains. Cancer Res.61:1406\u20131411.","journal-title":"Cancer Res."},{"key":"e_1_3_2_39_2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/gut.38.4.498","volume":"38","year":"1996","unstructured":"Moss, S. F., J. Calam, B. Agarwal, S. Wang, and P. R. Holt. 1996. Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut38:498\u2013501.","journal-title":"Gut"},{"key":"e_1_3_2_40_2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1136\/gut.33.6.738","volume":"33","year":"1992","unstructured":"Nielsen, H., and L. P. Andersen. 1992. Chemotactic activity of Helicobacter pylori sonicate for human polymorphonuclear leucocytes and monocytes. Gut33:738\u2013742.","journal-title":"Gut"},{"key":"e_1_3_2_41_2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0002-9440(10)64006-0","volume":"158","year":"2001","unstructured":"Nogueira, C., C. Figueiredo, F. Carneiro, A. T. Gomes, R. Barreira, P. Figueira, C. Salgado, L. Belo, A. Peixoto, J. C. Bravo, L. E. Bravo, J. L. Realpe, A. P. Plaisier, W. G. Quint, B. Ruiz, P. Correa, and L. J. van Doorn. 2001. Helicobacter pylori genotypes may determine gastric histopathology. Am. J. Pathol.158:647\u2013654.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1902-1908.2001"},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.287.5457.1497","volume":"287","year":"2000","unstructured":"Odenbreit, S., J. Puls, B. Sedlmaier, E. Gerland, W. Fischer, and R. Haas. 2000. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science287:1497\u20131500.","journal-title":"Science"},{"key":"e_1_3_2_44_2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1046\/j.1365-2036.2000.014s1205.x","volume":"14","year":"2000","unstructured":"Ohsuga, M., K. Kusugami, K. Ina, T. Ando, H. Yamaguchi, A. Imada, Y. Nishio, M. Shimada, T. Tsuzuki, M. Noshiro, T. Konagaya, and H. Kaneko. 2000. Comparison between in vivo and in vitro chemokine production in Helicobacter pylori infection. Aliment. Pharmacol. Ther.14(Suppl.1):205\u2013215.","journal-title":"Aliment. Pharmacol. Ther."},{"key":"e_1_3_2_45_2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1086\/515601","volume":"178","year":"1998","unstructured":"Pan, Z. J., D. E. Berg, R. W. van der Hulst, W. W. Su, A. Raudonikiene, S. D. Xiao, J. Dankert, G. N. Tytgat, and A. van der Ende. 1998. Prevalence of vacuolating cytotoxin production and distribution of distinct vacA alleles in Helicobacter pylori from China. J. Infect. Dis.178:220\u2013226.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_2_46_2","first-page":"6124","volume":"59","year":"1999","unstructured":"Peek, R. M., Jr., M. J. Blaser, D. J. Mays, M. H. Forsyth, T. L. Cover, S. Y. Song, U. Krishna, and J. A. Pietenpol. 1999. Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle. Cancer Res.59:6124\u20136131.","journal-title":"Cancer Res."},{"key":"e_1_3_2_47_2","first-page":"760","volume":"71","year":"1995","unstructured":"Peek, R. M., G. G. Miller, K. T. Tham, G. I. Perez-Perez, X. Zhao, J. C. Atherton, and M. J. Blaser. 1995. Heightened inflammatory response and cytokine expression in vivo to cagA+Helicobacter pylori strains. Lab. Investig.71:760\u2013770.","journal-title":"Lab. Investig."},{"key":"e_1_3_2_48_2","first-page":"531","volume":"110","year":"1998","unstructured":"Peek, R. M., S. A. Thompson, J. P. Donahue, K. T. Tham, J. C. Atherton, M. J. Blaser, and G. G. Miller. 1998. Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome. Proc. Assoc. Am. Physicians110:531\u2013544.","journal-title":"Proc. Assoc. Am. Physicians"},{"key":"e_1_3_2_49_2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/jnci\/89.12.863","volume":"89","year":"1997","unstructured":"Peek, R. M., S. F. Moss, K. T. Tham, G. I. Perez-Perez, S. Wang, G. G. Miller, J. C. Atherton, P. R. Holt, and M. J. Blaser. 1997. Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis. J. Natl. Cancer Inst.89:863\u2013868.","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_3_2_50_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1440-1746.1991.tb01468.x","volume":"6","year":"1991","unstructured":"Price, A. B. 1991. The Sydney System: histological division. J. Gastroenterol. Hepatol.6:209\u2013222.","journal-title":"J. Gastroenterol. Hepatol."},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.7.2829-2833.1996"},{"key":"e_1_3_2_52_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1023\/A:1026636803101","volume":"44","year":"1999","unstructured":"Rokkas, T., S. Ladas, C. Liatsos, E. Petridou, G. Papatheodorou, S. Theocharis, A. Karameris, and S. Raptis. 1999. Relationship of Helicobacter pylori CagA status to gastric cell proliferation and apoptosis. Dig. Dis. Sci.44:487\u2013493.","journal-title":"Dig. Dis. Sci."},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.8.3310-3316.1997"},{"key":"e_1_3_2_54_2","doi-asserted-by":"crossref","first-page":"14668","DOI":"10.1073\/pnas.97.26.14668","volume":"97","year":"2000","unstructured":"Salama, N., K. Guillemin, T. K. McDaniel, G. Sherlock, L. Tompkins, and S. Falkow. 2000. A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains. Proc. Natl. Acad. Sci. USA97:14668\u201314673.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_55_2","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.1073\/pnas.94.14.7595","volume":"94","year":"1997","unstructured":"Segal, E. D., C. Lange, A. Covacci, L. S. Tompkins, and S. Falkow. 1997. Induction of host signal transduction pathways by Helicobacter pylori. Proc. Natl. Acad. Sci. USA94:7595\u20137599.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.5.1681-1687.1995"},{"key":"e_1_3_2_57_2","doi-asserted-by":"crossref","first-page":"12619","DOI":"10.1073\/pnas.95.21.12619","volume":"95","year":"1998","unstructured":"Suerbaum, S., J. M. Smith, K. Bapumia, G. Morelli, N. H. Smith, E. Kunstmann, I. Dyrek, and M. Achtman. 1998. Free recombination within Helicobacter pylori.Proc. Natl. Acad. Sci. USA95:12619\u201312624.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/41483"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.5.1799-1809.1993"},{"key":"e_1_3_2_60_2","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1365-2958.1995.18050867.x","volume":"18","year":"1995","unstructured":"Tummuru, M. K., S. A. Sharma, and M. J. Blaser. 1995. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol. Microbiol.18:867\u2013876.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.5.1822-1826.1998"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70065-X"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1271-1276.1998"},{"key":"e_1_3_2_64_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0016-5085(98)70365-8","volume":"115","year":"1998","unstructured":"van Doorn, L. J., C. Figueiredo, R. Sanna, A. Plaisier, P. Schneeberger, W. de Boer, and W. Quint. 1998. Clinical relevance of the cagA,vacA, and iceA status of Helicobacter pylori.Gastroenterology115:58\u201366.","journal-title":"Gastroenterology"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.7.2306-2311.1999"},{"key":"e_1_3_2_66_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/gut.46.3.321","volume":"46","year":"2000","unstructured":"van Doorn, L. J., P. M. Schneeberger, N. Nouhan, A. P. Plaisier, W. G. Quint, and W. A. de Boer. 2000. Importance of Helicobacter pylori cagA and vacA status for the efficacy of antibiotic treatment. Gut46:321\u2013326.","journal-title":"Gut"},{"key":"e_1_3_2_67_2","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/S0016-5085(97)70003-9","volume":"113","year":"1997","unstructured":"Wagner, S., W. Beil, J. Westermann, R. P. Logan, C. T. Bock, C. Trautwein, J. S. Bleck, and M. P. Manns. 1997. Regulation of gastric epithelial cell growth by Helicobacter pylori: evidence for a major role of apoptosis. Gastroenterology113:1836\u20131847.","journal-title":"Gastroenterology"},{"key":"e_1_3_2_68_2","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1073\/pnas.130079797","volume":"97","year":"2000","unstructured":"Yamaoka, Y., D. H. Kwon, and D. Y. Graham. 2000. A M(r) 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori. Proc. Natl. Acad. Sci. USA97:7533\u20137538.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_3_2_69_2","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1053\/gast.1996.v110.pm8964399","volume":"110","year":"1996","unstructured":"Yamaoka, Y., M. Kita, T. Kodama, N. Sawai, and J. Imanishi. 1996. Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa. Gastroenterology110:1744\u20131752.","journal-title":"Gastroenterology"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.9.1.167-175.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.9.1.167-175.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:13:37Z","timestamp":1704500017000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CDLI.9.1.167-175.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1128\/CDLI.9.1.167-175.2002"],"URL":"https:\/\/doi.org\/10.1128\/cdli.9.1.167-175.2002","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"2001-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}