{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:00:43Z","timestamp":1790978443293,"version":"4.1.0"},"reference-count":9,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    African tick-bite fever, caused by\n                    <jats:italic>Rickettsia africae<\/jats:italic>\n                    , is the most common tick-borne rickettsiosis in sub-Saharan Africa. Mediterranean spotted fever due to\n                    <jats:italic>Rickettsia conorii<\/jats:italic>\n                    also occurs in the region but is more prevalent in Mediterranean countries. Using microimmunofluorescence, we compared the development of immunoglobulin G (IgG) and IgM titers in 48 patients with African tick-bite fever and 48 patients with Mediterranean spotted fever. Doxycycline treatment within 7 days from the onset of disease significantly prevented the development of antibodies to\n                    <jats:italic>R. africae<\/jats:italic>\n                    . In patients with African tick-bite fever, the median times to seroconversion with IgG and IgM were 28 and 25 days, respectively, after the onset of symptoms. These were significantly longer by a median of 6 days for IgG and 9 days for IgM than the times for seroconversion in patients with Mediterranean spotted fever (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 10\n                    <jats:sup>\u22122<\/jats:sup>\n                    ). We recommend that sera collected 4 weeks after the onset of signs of patients with suspected African tick-bite fever should be used for the definitive serological diagnosis of\n                    <jats:italic>R. africae<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1128\/cdli.9.2.324-328.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:58:35Z","timestamp":1027749515000},"page":"324-328","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Kinetics of Antibody Responses in\n                    <i>Rickettsia africae<\/i>\n                    and\n                    <i>Rickettsia conorii<\/i>\n                    Infections"],"prefix":"10.1128","volume":"9","author":[{"given":"Pierre-Edouard","family":"Fournier","sequence":"first","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS:UPRESA 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mogens","family":"Jensenius","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Aker University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Laferl","sequence":"additional","affiliation":[{"name":"Medical Department, Kaiser Franz Josef Hospital, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirka","family":"Vene","sequence":"additional","affiliation":[{"name":"Department of Virology, Swedish Institute for Infectious Disease Control, Solna, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, CNRS:UPRESA 6020, Faculte\u0301 de Me\u0301decine, Universite\u0301 de la Me\u0301diterrane\u0301e, 13385 Marseille Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"62","volume":"36","year":"1992","unstructured":"Beati, L., N. Teysseire, and D. Raoult. 1992. Kinetics of specific antibodies in Mediterranean spotted fever determined by Western blotting and microimmunofluorescence. Acta Virol.36:62-66.","journal-title":"Acta Virol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1086\/514664","volume":"27","year":"1998","unstructured":"Fournier, P. E., V. Roux, E. Caumes, M. Donzel, and D. Raoult. 1998. Outbreak of Rickettsia africae infections in participants of an adventure race from South Africa. Clin. Infect. Dis.27:316-323.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1099\/00222615-29-3-199","volume":"29","year":"1989","unstructured":"Hechemy, K. E., D. Raoult, J. Fox, Y. Han, L. B. Elliott, and J. Rawlings. 1989. Cross-reaction of immune sera from patients with rickettsial diseases. J. Med. Microbiol.29:199-202.","journal-title":"J. Med. Microbiol."},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1099\/00207713-46-2-611","volume":"46","year":"1996","unstructured":"Kelly, P. J., L. Beati, P. R. Mason, L. A. Matthewman, V. Roux, and D. Raoult. 1996. Rickettsia africae sp nov, the etiological agent of African tick bite fever. Int. J. Syst. Bacteriol.46:611-614.","journal-title":"Int. J. Syst. Bacteriol."},{"key":"e_1_3_2_6_2","first-page":"20","volume":"590","year":"1991","unstructured":"McDade, J. E. 1991. Evidence supporting the hypothesis that rickettsial virulence factors determine the severity of spotted fever and typhus group infections. Ann. N. Y. Acad. Science590:20-26.","journal-title":"Ann. N. Y. Acad. Science"},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1056\/NEJM199805073381918","volume":"338","year":"1998","unstructured":"Parola, P., J. Jourdan, and D. Raoult. 1998. Tick-borne infection caused by Rickettsia africae in the West Indies. N. Engl. J. Med.338:1391-1392.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1056\/NEJM200105173442003","volume":"344","year":"2001","unstructured":"Raoult, D., P. E. Fournier, F. Fenollar, M. Jensenius, T. Prioe, J. J. de Pina, G. Caruso, N. Jones, H. Laferl, J. E. Rosenblatt, and T. J. Marrie. 2001. Rickettsia africae, a tick-borne pathogen in travelers to Sub-Saharan Africa. N. Engl. J. Med.344:1504-1510.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_9_2","first-page":"192","volume":"8","year":"1992","unstructured":"Raoult, D., H. Tissot-Dupont, P. Caraco, P. Brouqui, M. Drancourt, and C. Charrel. 1992. Mediterranean spotted fever in Marseille: descriptive epidemiology and the influence climatic factors. Eur. J. Epidemiol.8:192-197.","journal-title":"Eur. J. Epidemiol."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.7.1537"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.9.2.324-328.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.9.2.324-328.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T16:31:38Z","timestamp":1627576298000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CDLI.9.2.324-328.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1128\/CDLI.9.2.324-328.2002"],"URL":"https:\/\/doi.org\/10.1128\/cdli.9.2.324-328.2002","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]},"assertion":[{"value":"2001-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}