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In the present study, we examined the potential role of a neurotransmitter, substance P, in a mouse model of IBD. We found that binding sites for substance P, and more specifically, neurokinin-1 receptors, were upregulated in intestinal tissue of mice with IBD-like syndrome. Dosing of mice with LY303870, a neurokinin-1 receptor antagonist, reduced the severity of IBD, and treatment of mice with preexisting IBD allowed partial healing of lesions. We hypothesize that blocking the binding of substance P to the neurokinin-1 receptor interrupts the inflammatory cascade that triggers and maintains intestinal lesions of IBD.<\/jats:p>","DOI":"10.1128\/cdli.9.2.333-340.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:58:35Z","timestamp":1027763915000},"page":"333-340","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Treatment with Neurokinin-1 Receptor Antagonist Reduces Severity of Inflammatory Bowel Disease Induced by<i>Cryptosporidium parvum<\/i>"],"prefix":"10.1128","volume":"9","author":[{"given":"Ioana M.","family":"Sonea","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell V.","family":"Palmer","sequence":"additional","affiliation":[{"name":"National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhuha","family":"Akili","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Harp","sequence":"additional","affiliation":[{"name":"National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"120","volume":"5","year":"1993","unstructured":"Agro, A., and A. 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