{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:18:59Z","timestamp":1777515539419,"version":"3.51.4"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Epidemiological studies have suggested an association between antacid therapy and development of listeriosis in humans. In this study we used a neutropenic mouse model to demonstrate that oral administration of sodium bicarbonate shortly before intragastric (i.g.) inoculation with<jats:italic>Listeria monocytogenes<\/jats:italic>EGD (serotype 1\/2a) significantly increased the severity of the resulting systemic infection. An explanation for this observation is provided by evidence that<jats:italic>L. monocytogenes<\/jats:italic>EGD is rapidly inactivated in synthetic gastric fluid at pH below 5. A second strain of<jats:italic>L. monocytogenes<\/jats:italic>(CM [serotype 1\/2b]) exhibited little ability to cause systemic infection following i.g. inoculation and was not significantly enhanced by administration of sodium bicarbonate. Strain CM was readily inactivated in synthetic gastric fluid even at pH 7. These data suggest that gastric acidity and enzymes provide some innate defense against gastrointestinal listeriosis in neutropenic mice.<\/jats:p>","DOI":"10.1128\/cdli.9.2.477-481.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:58:35Z","timestamp":1027763915000},"page":"477-481","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":7,"title":["Sodium Bicarbonate Enhances the Severity of Infection in Neutropenic Mice Orally Inoculated with<i>Listeria monocytogenes<\/i>EGD"],"prefix":"10.1128","volume":"9","author":[{"given":"C. J.","family":"Czuprynski","sequence":"first","affiliation":[{"name":"Department of Pathobiological Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. G.","family":"Faith","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences"},{"name":"School of Veterinary Medicine, and Food Research Institute, University of Wisconsin\u2014Madison, Madison, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"1071","volume":"8","year":"1996","unstructured":"Cobb, C. A., G. D. W. Curtis, D. S. Bansi, E. Slade, W. Mehal, R. G. Mitchell, and R. W. Chapman. 1996. Increased prevalence of Listeria monocytogenes in the faeces of patients receiving long-term H-2-antagonists. Gastroenterol. Hepatol.8:1071-1074.","journal-title":"Gastroenterol. Hepatol."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1099\/00222615-46-3-239","volume":"46","year":"1997","unstructured":"Conlan, J. W. 1997. 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