{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:26:55Z","timestamp":1759332415531},"reference-count":14,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In this study we demonstrated that combined inoculation of interleukin-12 (IL-12) and IL-18 reduced the number of bacteria in the spleens of mice infected with<jats:italic>Brucella abortus<\/jats:italic>2308 and that the effect of the treatment was mediated by an increased capability of spleen cells to produce gamma interferon at the early phase of infection.<\/jats:p>","DOI":"10.1128\/cdli.9.2.491-492.2002","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:58:35Z","timestamp":1027763915000},"page":"491-492","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Exogenous Interleukin-18 (IL-18) and IL-12 in the Course of<i>Brucella abortus<\/i>2308 Infection in Mice"],"prefix":"10.1128","volume":"9","author":[{"given":"Paolo","family":"Pasquali","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Medicine, Istituto Superiore di Sanita\u0300, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Adone","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Medicine, Istituto Superiore di Sanita\u0300, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis C.","family":"Gasbarre","sequence":"additional","affiliation":[{"name":"Immunology and Disease Resistance Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland 20705"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Pistoia","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Medicine, Istituto Superiore di Sanita\u0300, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Ciuchini","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Medicine, Istituto Superiore di Sanita\u0300, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.1.124-134.1993"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.7.3011-3014.1992"},{"key":"e_1_3_1_4_2","first-page":"284","volume":"63","year":"1999","unstructured":"Lee, I., S. C. Olsen, M. Kehrli, and C. A. Bolin. 1999. The adjuvant effect of a single dose of interleukin-12 on murine immune response to live or killed Brucella abortus strain RB51. Can. J. Vet. Res.63:284-287.","journal-title":"Can. J. Vet. Res."},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1002\/eji.1830260736","volume":"26","year":"1996","unstructured":"Micallef, M., T. Ohtsuki, K. Kohno, F. Tanabe, S. Ushio, M. Namba, T. Tanimoto, K. Torigoe, K. Fujii, M. Ikeda, S. Fukuda, and M. Kurimoto. 1996. Interferon-gamma-inducing factor enhances T helper, 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur. J. Immunol.26:1647-1651.","journal-title":"Eur. J. Immunol."},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/378088a0","volume":"378","year":"1995","unstructured":"Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, K. Akita, M. Namba, F. Tanabe, K. Konishi, S. Fukuda, and M. Kurimoto. 1995. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature378:88-91.","journal-title":"Nature"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0952-7915(98)80163-5","volume":"10","year":"1998","unstructured":"Okamura, H., S. Kashiwamura, H. Tsutsui, T. Yoshimoto, and K. Nakanishi. 1998. Regulation of interferon-\u03b3 production by IL-12 and IL-18. Curr. Opin. Immunol.10:259-264.","journal-title":"Curr. Opin. Immunol."},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6541-6544.2001"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.4.611"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.10.4407-4409.1992"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/08830189809043002","volume":"16","year":"1998","unstructured":"Trinchieri, G. 1998. Proinflammatory and immunoregulatory functions of interleukin-12. Int. Rev. Immunol.16:365-396.","journal-title":"Int. Rev. Immunol."},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.4049\/jimmunol.156.11.4274","volume":"156","year":"1996","unstructured":"Ushio, S., M. Namba, T. Okura, K. Hattori, Y. Nukada, K. Akita, F. Tanabe, K. Konishi, M. Micallef, M. Fujii, K. Torigoe, T. Tanimoto, S. Fukuda, M. Ikeda, H. Okamura, and M. Kurimoto. 1996. Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol.156:4274-4279.","journal-title":"J. Immunol."},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.11.4899-4901.1993"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.4.1387-1390.1995"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.7.2782-2786.1996"}],"container-title":["Clinical and Vaccine Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.9.2.491-492.2002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CDLI.9.2.491-492.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T15:10:47Z","timestamp":1682262647000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CDLI.9.2.491-492.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1128\/CDLI.9.2.491-492.2002"],"URL":"https:\/\/doi.org\/10.1128\/cdli.9.2.491-492.2002","relation":{},"ISSN":["1556-6811","1556-679X"],"issn-type":[{"value":"1556-6811","type":"print"},{"value":"1556-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]},"assertion":[{"value":"2001-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}