{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:59:02Z","timestamp":1791035942114,"version":"4.1.0"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:italic>Bartonella<\/jats:italic>\n            endocarditis is a disease of emerging importance that causes serious complications and high rates of mortality. Due to the fastidious nature of\n            <jats:italic>Bartonella<\/jats:italic>\n            species and their high degrees of antibiotic susceptibility, cultures of clinical samples most often remain sterile and valvular biopsy specimens, the best specimens for PCR amplification, are seldom available. Therefore, serology appears to be the easiest diagnostic tool. In order to determine the best cutoff value for serology and its predictive values for the detection of\n            <jats:italic>Bartonella<\/jats:italic>\n            endocarditis, we studied 48 patients with culture- and\/or PCR-confirmed\n            <jats:italic>Bartonella<\/jats:italic>\n            endocarditis. We also applied these serological criteria to 156 patients with blood culture-negative endocarditis. Furthermore, we compared the kinetics of the antibody responses to\n            <jats:italic>Bartonella<\/jats:italic>\n            spp. in order to estimate the value of serology for prediction of the occurrence of relapses. A titer of \u22651:800 for immunoglobulin G antibodies to either\n            <jats:italic>Bartonella henselae<\/jats:italic>\n            or\n            <jats:italic>B. quintana<\/jats:italic>\n            has a positive predictive value of 0.810 for the detection of chronic\n            <jats:italic>Bartonella<\/jats:italic>\n            infections in the general population and a value of 0.955 for the detection of\n            <jats:italic>Bartonella<\/jats:italic>\n            infections among patients with endocarditis. When this cutoff was applied to 156 patients with blood culture-negative endocarditis, we were able to diagnose\n            <jats:italic>Bartonella<\/jats:italic>\n            infections in an additional 45 patients with definite endocarditis for whom a positive\n            <jats:italic>Bartonella<\/jats:italic>\n            serology was the only evidence of infection. On follow-up, the kinetics of the decrease in antibody titers were significantly delayed in two patients with relapses. In conclusion, we recommend the determination of antibodies to both\n            <jats:italic>B. quintana<\/jats:italic>\n            and\n            <jats:italic>B. henselae<\/jats:italic>\n            and the use of a cutoff value of 1:800 for the diagnosis of\n            <jats:italic>Bartonella<\/jats:italic>\n            endocarditis. We propose that this criterion, which may also help with the detection of late relapses, be included as a major criterion in the Duke criteria for the diagnosis of infective endocarditis.\n          <\/jats:p>","DOI":"10.1128\/cdli.9.4.795-801.2002","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:07:23Z","timestamp":1027897643000},"page":"795-801","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Value of Microimmunofluorescence for Diagnosis and Follow-up of\n            <i>Bartonella<\/i>\n            Endocarditis"],"prefix":"10.1128","volume":"9","author":[{"given":"Pierre-Edouard","family":"Fournier","sequence":"first","affiliation":[{"name":"Unite\u0301 des Rickettsies, IFR 48 CNRS, UMR 6020 Universite\u0301 de la Me\u0301diterrane\u0301e, Faculte\u0301 de Me\u0301decine, 13385 Marseille Cedex 05"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Mainardi","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie Ho\u0302pital Europe\u0301en Georges Pompidou, 75908 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Rickettsies, IFR 48 CNRS, UMR 6020 Universite\u0301 de la Me\u0301diterrane\u0301e, Faculte\u0301 de Me\u0301decine, 13385 Marseille Cedex 05"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0022-3476(98)70410-X","volume":"132","year":"1998","unstructured":"Baorto, E., R. M. Payne, L. N. Slater, F. Lopez, D. A. Relman, K. W. Min, and J. W. St. Geme. 1998. Culture-negative endocarditis caused by Bartonella henselae. J. Pediatr.132:1051-1054.","journal-title":"J. Pediatr."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1136\/hrt.77.5.474","volume":"77","year":"1997","unstructured":"Breathnach, A. S., J. M. Hoare, and S. J. Eykyn. 1997. Culture-negative endocarditis: contribution of bartonella infections. Heart77:474-476.","journal-title":"Heart"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/00365549850160783","volume":"30","year":"1998","unstructured":"Bruneel, F., J. D'Estanque, P. E. Fournier, G. Arlet, M. Thuong, M. Wolff, J. P. Bedos, S. Lariven, and B. Regnier. 1998. Isolated right-sided Bartonella quintana endocarditis in an immunocompetent adult. Scand. J. Infect. Dis.30:424-425.","journal-title":"Scand. J. Infect. 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