{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T22:07:19Z","timestamp":1773698839256,"version":"3.50.1"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2002,9,1]],"date-time":"2002-09-01T00:00:00Z","timestamp":1030838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The clinical significance of high levels of antibody against\n            <jats:italic>Helicobacter pylori<\/jats:italic>\n            is still unclear. We sought to evaluate whether the serum antibody levels could predict the presence of macroscopic gastroduodenal disease, to identify factors that correlate with antibody levels in a multivariate context, and to determine the predictive value of antibody levels for diagnosing\n            <jats:italic>H. pylori<\/jats:italic>\n            infection. The grades of gastritis and density of\n            <jats:italic>H. pylori<\/jats:italic>\n            colonization were scored separately using the updated Sydney system for antral and body mucosa. An enzyme-linked immunosorbent assay (ELISA) for the quantitative detection in serum of IgG antibodies to\n            <jats:italic>H. pylori<\/jats:italic>\n            was performed. Of the 170 dyspeptic patients, 105 (62%) had\n            <jats:italic>H. pylori<\/jats:italic>\n            infection. There was no difference in antibody levels among endoscopic findings of normal mucosa, chronic gastritis, and duodenal ulcer. On multivariate linear regression analysis, the status of\n            <jats:italic>H. pylori<\/jats:italic>\n            infection, mononuclear cell infiltration of body mucosa, and age correlated with antibody levels. The negative predictive value for antibody levels of &lt;30 U\/ml is 94%, and the positive predictive value of antibody levels of &gt;70 U\/ml is 98%. We conclude that serum antibody levels do not predict the severity of gastroduodenal diseases or the density of\n            <jats:italic>H. pylori<\/jats:italic>\n            colonization in\n            <jats:italic>H. pylori<\/jats:italic>\n            -infected dyspeptic patients. Higher levels are associated with the presence of\n            <jats:italic>H. pylori<\/jats:italic>\n            infection, the chronic gastritis score of the corpus, and older age. Setting a gray zone is necessary for ELISA, since the accuracy in this zone does not allow a precise determination of\n            <jats:italic>H. pylori<\/jats:italic>\n            status.\n          <\/jats:p>","DOI":"10.1128\/cdli.9.5.1044-1048.2002","type":"journal-article","created":{"date-parts":[[2002,8,30]],"date-time":"2002-08-30T18:44:29Z","timestamp":1030733069000},"page":"1044-1048","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Immunoglobulin G Antibody against\n            <i>Helicobacter pylori<\/i>\n            : Clinical Implications of Levels Found in Serum"],"prefix":"10.1128","volume":"9","author":[{"given":"Tseng-Shing","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, and Department of Pathology,Taipei Veterans General Hospital"},{"name":"National Yang-Ming University, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen-Yau","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, and Department of Pathology,Taipei Veterans General Hospital"},{"name":"National Yang-Ming University, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Full-Young","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, and Department of Pathology,Taipei Veterans General Hospital"},{"name":"National Yang-Ming University, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou-Dong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, and Department of Pathology,Taipei Veterans General Hospital"},{"name":"National Yang-Ming University, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.1.184-186.1997"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1046\/j.1440-1746.2001.02630.x","volume":"16","year":"2001","unstructured":"Chen, T. 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