{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:21:22Z","timestamp":1791102082752,"version":"4.1.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Mycobacterium ulcerans<\/jats:italic>disease, or Buruli ulcer (BU), causes significant morbidity in West Africa. In 233 consecutive, laboratory-confirmed samples from BU patients in Benin whose<jats:italic>Mycobacterium bovis<\/jats:italic>BCG scar status was known, 130 children (&lt;15 years old) and 75 adults had a neonatal BCG vaccination scar. Of 130 children with BCG scars, 10 (7.7%) had osteomyelitis, while 3 of 9 children without BCG scars (33.3%) had osteomyelitis. Our observations support the conclusion that having a BCG vaccination scar provides significant protection against<jats:italic>M. ulcerans<\/jats:italic>osteomyelitis in children with BU disease.<\/jats:p>","DOI":"10.1128\/cdli.9.6.1389-1391.2002","type":"journal-article","created":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T19:04:24Z","timestamp":1036177464000},"page":"1389-1391","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Prophylactic Effect of<i>Mycobacterium bovis<\/i>BCG Vaccination against Osteomyelitis in Children with<i>Mycobacterium ulcerans<\/i>Disease (Buruli Ulcer)"],"prefix":"10.1128","volume":"9","author":[{"given":"F.","family":"Portaels","sequence":"first","affiliation":[{"name":"Department of Microbiology, Institute of Tropical Medicine, 2000 Antwerp, Belgium"},{"name":"Centre Sanitaire et Nutritionnel, Gbemoten, Zagnanado"},{"name":"Programme National de Lutte contre l'Ulce\u0300re de Buruli, Ministe\u0300re de la Sante\u0301, Cotonou, Be\u0301nin"},{"name":"Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Tropical Medicine, 2000 Antwerp, Belgium"},{"name":"Centre Sanitaire et Nutritionnel, Gbemoten, Zagnanado"},{"name":"Programme National de Lutte contre l'Ulce\u0300re de Buruli, Ministe\u0300re de la Sante\u0301, Cotonou, Be\u0301nin"},{"name":"Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Debacker","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Tropical Medicine, 2000 Antwerp, Belgium"},{"name":"Centre Sanitaire et Nutritionnel, Gbemoten, Zagnanado"},{"name":"Programme National de Lutte contre l'Ulce\u0300re de Buruli, Ministe\u0300re de la Sante\u0301, Cotonou, Be\u0301nin"},{"name":"Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Steunou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Tropical Medicine, 2000 Antwerp, Belgium"},{"name":"Centre Sanitaire et Nutritionnel, Gbemoten, Zagnanado"},{"name":"Programme National de Lutte contre l'Ulce\u0300re de Buruli, Ministe\u0300re de la Sante\u0301, Cotonou, Be\u0301nin"},{"name":"Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Zinsou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Tropical Medicine, 2000 Antwerp, Belgium"},{"name":"Centre Sanitaire et Nutritionnel, Gbemoten, Zagnanado"},{"name":"Programme National de Lutte contre l'Ulce\u0300re de Buruli, Ministe\u0300re de la Sante\u0301, Cotonou, Be\u0301nin"},{"name":"Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gue\u0301de\u0301non","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Tropical Medicine, 2000 Antwerp, Belgium"},{"name":"Centre Sanitaire et Nutritionnel, Gbemoten, Zagnanado"},{"name":"Programme National de Lutte contre l'Ulce\u0300re de Buruli, Ministe\u0300re de la Sante\u0301, Cotonou, Be\u0301nin"},{"name":"Department of Infectious and Parasitic Disease Pathology, Armed Forces Institute of Pathology, Washington, D.C. 20306"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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