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Infection generally occurs by traumatic inoculation of soil, plants, and organic matter contaminated with the fungus. Certain leisure and occupational activities, such as floriculture, agriculture, mining, and wood exploitation, are traditionally associated with the mycosis. Zoonotic transmission has been described in isolated cases or in small outbreaks. Since the end of the 1990s there has been an epidemic of sporotrichosis associated with transmission by cats in Rio de Janeiro, Brazil. More than 2,000 human cases and 3,000 animal cases have been reported. In humans, the lesions are usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. In cats, the disease can evolve with severe clinical manifestations and frequent systemic involvement. The gold standard for sporotrichosis diagnosis is culture. However, serological, histopathological, and molecular approaches have been recently adopted as auxiliary tools for the diagnosis of this mycotic infection. The first-choice treatment for both humans and cats is itraconazole.\n                  <\/jats:p>","DOI":"10.1128\/cmr.00007-11","type":"journal-article","created":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T14:20:57Z","timestamp":1317824457000},"page":"633-654","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":558,"title":["Sporothrix schenckii and Sporotrichosis"],"prefix":"10.1128","volume":"24","author":[{"given":"M\u00f4nica Bastos de Lima","family":"Barros","sequence":"first","affiliation":[{"name":"National School of Public Health, Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"de Almeida Paes","sequence":"additional","affiliation":[{"name":"Evandro Chagas Clinical Research Institute, Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando Oliveira","family":"Schubach","sequence":"additional","affiliation":[{"name":"Evandro Chagas Clinical Research Institute, Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a120910"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00440950"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01160.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652009000400012"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.03.002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00149-07"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00430-06"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/516356"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01176-06"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822010000500010"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0095-z"},{"key":"e_1_3_2_13_2","first-page":"409","article-title":"Esporotricose. 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