{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:43:41Z","timestamp":1793148221194,"version":"4.5.0"},"reference-count":367,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Microbiol Rev"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:title>SUMMARY<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      is a gastric pathogen that colonizes approximately 50% of the world's population. Infection with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      causes chronic inflammation and significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer. Infection with\n                      <jats:italic>H. pylori<\/jats:italic>\n                      is the strongest known risk factor for gastric cancer, which is the second leading cause of cancer-related deaths worldwide. Once\n                      <jats:italic>H. pylori<\/jats:italic>\n                      colonizes the gastric environment, it persists for the lifetime of the host, suggesting that the host immune response is ineffective in clearing this bacterium. In this review, we discuss the host immune response and examine other host factors that increase the pathogenic potential of this bacterium, including host polymorphisms, alterations to the apical-junctional complex, and the effects of environmental factors. In addition to host effects and responses,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      strains are genetically diverse. We discuss the main virulence determinants in\n                      <jats:italic>H. pylori<\/jats:italic>\n                      strains and the correlation between these and the diverse clinical outcomes following\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection. Since\n                      <jats:italic>H. pylori<\/jats:italic>\n                      inhibits the gastric epithelium of half of the world, it is crucial that we continue to gain understanding of host and microbial factors that increase the risk of developing more severe clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/cmr.00011-10","type":"journal-article","created":{"date-parts":[[2010,10,7]],"date-time":"2010-10-07T13:12:56Z","timestamp":1286457176000},"page":"713-739","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1275,"title":["<i>Helicobacter pylori<\/i>\n                    and Gastric Cancer: Factors That Modulate Disease Risk"],"prefix":"10.1128","volume":"23","author":[{"given":"Lydia E.","family":"Wroblewski","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Richard M.","family":"Peek","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine"},{"name":"Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232"},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith T.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine"},{"name":"Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232"},{"name":"Department of Veterans Affairs Medical Center, Nashville, Tennessee 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/383787a0"},{"key":"e_1_3_2_3_2","first-page":"1031","volume":"13","year":"1998","unstructured":"Adachi, Y., F. Itoh, H. Yamamoto, K. Matsuno, Y. Arimura, M. Kusano, T. Endoh, Y. Hinoda, M. Oohara, M. Hosokawa, and K. Imai. 1998. Matrix metalloproteinase matrilysin (MMP-7) participates in the progression of human gastric and esophageal cancers. Int. J. Oncol.13:1031-1035.","journal-title":"Int. J. Oncol."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.6977"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.5024"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.8144"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/90609"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2958.1998.00770.x","volume":"28","year":"1998","unstructured":"Akopyants, N. S., S. W. Clifton, D. Kersulyte, J. E. Crabtree, B. E. Youree, C. A. Reece, N. O. Bukanov, E. S. Drazek, B. A. Roe, and D. E. Berg. 1998. Analyses of the cag pathogenicity island of Helicobacter pylori. Mol. Microbiol.28:37-53.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1702"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00338.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.1.115"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/16495"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27177"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00222.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081919"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00258-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502040102"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.9.5306"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.1635"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1086\/522177"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.2008\/001818-0"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.593"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020110"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098801"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.1.110304.100125"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.30.17771"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70223-3"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2363"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502598102"},{"key":"e_1_3_2_30_2","first-page":"1279","volume":"56","year":"1996","unstructured":"Baik, S. C., H. S. Youn, M. H. Chung, W. K. Lee, M. J. Cho, G. H. Ko, C. K. Park, H. Kasai, and K. H. Rhee. 1996. Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa. Cancer Res.56:1279-1282.","journal-title":"Cancer Res."},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70531-1"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.767"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.041"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000133736.77866.77"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12672"},{"key":"e_1_3_2_36_2","first-page":"562","volume":"55","year":"1995","unstructured":"Blaser, M. J., P. H. Chyou, and A. Nomura. 1995. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res.55:562-565.","journal-title":"Cancer Res."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030621"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8018146"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510275200"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01702-06"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10201"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2354"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4197"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400498200"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14648"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.4.502"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.077776"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00578-07"},{"key":"e_1_3_2_49_2","first-page":"A8","volume":"14","year":"2006","unstructured":"Chaturvedi, R., M. Asim, N. D. Lewis, F. I. Bussiere, and K. T. Wilson. 2006. Arginine availability is critical to the innate immune response to Helicobacter pylori by regulation of iNOS translation. Nitric Oxide14:A8.","journal-title":"Nitric Oxide"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401370200"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.138.4.891"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C500122200"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061884"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2007.03.012"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200208039"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5181-5192.2004"},{"key":"e_1_3_2_57_2","first-page":"477","volume":"5","year":"1996","unstructured":"Correa, P. 1996. Helicobacter pylori and gastric cancer: state of the art. Cancer Epidemiol. Biomarkers Prev.5:477-481.","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"e_1_3_2_58_2","first-page":"6735","volume":"52","year":"1992","unstructured":"Correa, P. 1992. Human gastric carcinogenesis: a multistep and multifactorial process\u2014First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res.52:6735-6740.","journal-title":"Cancer Res."},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.039834"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.23.1881"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.026"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.587"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50054-0"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.3.603-610.1990"},{"key":"e_1_3_2_65_2","first-page":"951","volume":"63","year":"2003","unstructured":"Cover, T. L., U. S. Krishna, D. A. Israel, and R. M. Peek, Jr. 2003. Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res.63:951-957.","journal-title":"Cancer Res."},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34097-8"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1083-4389.2002.00071.x"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.12.1473"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90477-7"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.10.1339"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01206-X"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270723"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.017"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00172-07"},{"key":"e_1_3_2_75_2","first-page":"1360","volume":"55","year":"2006","unstructured":"Dossumbekova, A., C. Prinz, M. Gerhard, L. Brenner, S. Backert, J. G. Kusters, R. M. Schmid, and R. Rad. 2006. Helicobacter pylori outer membrane proteins and gastric inflammation. Gut55:1360-1361.","journal-title":"Gut"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1159\/000229774"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.05.017"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01887-05"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7456"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.2.1025-1031.2001"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.7.2445-2448.1996"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000701)87:1<133::AID-IJC20>3.0.CO;2-E"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.743"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/35006081"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00157-4"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9149-2"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.615"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2220-7"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70130-8"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.4.1918"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.45.29745"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.3.351"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215093"},{"key":"e_1_3_2_94_2","first-page":"97","volume":"7","year":"1998","unstructured":"Farrow, D. C., T. L. Vaughan, P. D. Hansten, J. L. Stanford, H. A. Risch, M. D. Gammon, W. H. Chow, R. Dubrow, H. Ahsan, S. T. Mayne, J. B. Schoenberg, A. B. West, H. Rotterdam, J. F. Fraumeni, Jr., and W. J. Blot. 1998. Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol. Biomarkers Prev.7:97-102.","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.12.7844-7852.2005"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.22.1680"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.neo.7900190"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(96)81009-9"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2593"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/75015"},{"key":"e_1_3_2_101_2","first-page":"4823","volume":"59","year":"1999","unstructured":"Fox, J. G., C. A. Dangler, N. S. Taylor, A. King, T. J. Koh, and T. C. Wang. 1999. High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL\/6 mice. Cancer Res.59:4823-4828.","journal-title":"Cancer Res."},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M900139-MCP200"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504927102"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0824"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70496-8"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507063330107"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1112"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34156"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.23.6361"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9524-3"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01728-07"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2006.08.014"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086871"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.27.3.436-441.1989"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12778"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1086\/386289"},{"key":"e_1_3_2_117_2","first-page":"245","volume":"279","year":"2003","unstructured":"Gobert, A. P., J. C. Bambou, C. Werts, V. Balloy, M. Chignard, A. P. Moran, and R. L. Ferrero. 2003. Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a Toll-like receptor (TLR)-2-, TLR-4- and myeloid differentiation factor 88-independent mechanism. J. Biol. Chem.279:245-250.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.9.4692"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.241443798"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.6002"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.4.353"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.4.695"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.4163-4166.2003"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/35094017"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3925"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.10.4229-4235.1997"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.2.1249"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1086\/314426"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1433"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.4.658"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00348.x"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.9.658"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309964200"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067147"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503583200"},{"key":"e_1_3_2_137_2","first-page":"233","volume":"62","year":"2002","unstructured":"Hippo, Y., H. Taniguchi, S. Tsutsumi, N. Machida, J. M. Chong, M. Fukayama, T. Kodama, and H. Aburatani. 2002. Global gene expression analysis of gastric cancer by oligonucleotide microarrays. Cancer Res.62:233-240.","journal-title":"Cancer Res."},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01350.x"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.3.444"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026628601284"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.3.1189-1195.2000"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099513"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01737-07"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37043"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.373"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.33"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199910)189:2<180::AID-PATH414>3.0.CO;2-2"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl096"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.4237-4242.1999"},{"key":"e_1_3_2_150_2","first-page":"1695","volume":"151","year":"1997","unstructured":"Jones, N. L., P. T. Shannon, E. Cutz, H. Yeger, and P. M. Sherman. 1997. Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection. Am. J. Pathol.151:1695-1703.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.11.3010-3020.1995"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00324.x"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00139.2005"},{"key":"e_1_3_2_154_2","first-page":"1046","volume":"138","year":"2009","unstructured":"Kao, J. Y., M. Zhang, M. J. Miller, J. C. Mills, B. Wang, M. Liu, K. A. Eaton, W. Zou, B. E. Berndt, T. S. Cole, T. Takeuchi, S. Y. Owyang, and J. Luther. 2009. Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology138:1046-1054.","journal-title":"Gastroenterology"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01314-05"},{"key":"e_1_3_2_156_2","first-page":"4401","volume":"19","year":"1999","unstructured":"Karayiannakis, A. J., K. N. Syrigos, D. Alexiou, N. Kalahanis, T. Rosenberg, E. Bastounis, and M. Pignatelli. 1999. Expression patterns of the novel catenin p120cas in gastrointestinal cancers. Anticancer Res.19:4401-4405.","journal-title":"Anticancer Res."},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.3.341"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21810"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021531"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107630200"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2009.100"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.22.6969-6976.1999"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.1995.0198"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.8.4416-4423.2004"},{"key":"e_1_3_2_165_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.7.4180-4189.2005"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2007.04.003"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603307"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.8.5080-5087.2001"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.23.1777"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23190"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.13.162"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2003.09.018"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11248-005-7215-z"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2442"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-26-2-93"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902436"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb01466.x"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05562"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4746"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.01.009"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.001008"},{"key":"e_1_3_2_182_2","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1111\/j.1349-7006.2008.00950.x","volume":"99","year":"2008","unstructured":"Lu, H. S., Y. Saito, M. Umeda, N. Murata-Kamiya, H. M. Zhang, H. Higashi, and M. Hatakeyama. 2008. Structural and functional diversity in the PAR1b\/MARK2-binding region of Helicobacter pylori CagA. Cancer Sci.99:2004-2011.","journal-title":"Cancer Sci."},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.523-531.2005"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.4.1755-1762.2003"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.9.5332"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28049-0"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28000"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-004-0268-5"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069076"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.2.517"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115095"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21242"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04754"},{"key":"e_1_3_2_194_2","first-page":"3238","volume":"56","year":"1996","unstructured":"Mannick, E. E., L. E. Bravo, G. Zarama, J. L. Realpe, X. J. Zhang, B. Ruiz, E. T. Fontham, R. Mera, M. J. Miller, and P. Correa. 1996. Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants. Cancer Res.56:3238-3243.","journal-title":"Cancer Res."},{"key":"e_1_3_2_195_2","unstructured":"Reference deleted."},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7886456"},{"key":"e_1_3_2_197_2","first-page":"2325","volume":"118","year":"2008","unstructured":"Marcos, N. T., A. Magalhaes, B. Ferreira, M. J. Oliveira, A. S. Carvalho, N. Mendes, T. Gilmartin, S. R. Head, C. Figueiredo, L. David, F. Santos-Silva, and C. A. Reis. 2008. Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x. J. Clin. Invest.118:2325-2336.","journal-title":"J. Clin. Invest."},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50142"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.031"},{"key":"e_1_3_2_201_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940040617"},{"key":"e_1_3_2_202_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.072009"},{"key":"e_1_3_2_203_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.8.3913"},{"key":"e_1_3_2_204_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.11.6265-6272.2000"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000801)87:3<322::AID-IJC3>3.0.CO;2-M"},{"key":"e_1_3_2_206_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.09.005"},{"key":"e_1_3_2_207_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00681-0"},{"key":"e_1_3_2_208_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00228-06"},{"key":"e_1_3_2_209_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33534-2"},{"key":"e_1_3_2_210_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00856.x"},{"key":"e_1_3_2_211_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.6.3646-3649.2004"},{"key":"e_1_3_2_212_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.4.498"},{"key":"e_1_3_2_213_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.04.005"},{"key":"e_1_3_2_214_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210251"},{"key":"e_1_3_2_215_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri954"},{"key":"e_1_3_2_216_2","doi-asserted-by":"publisher","DOI":"10.1086\/596660"},{"key":"e_1_3_2_217_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.038"},{"key":"e_1_3_2_218_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806981200"},{"key":"e_1_3_2_219_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5857-5863.2001"},{"key":"e_1_3_2_220_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.049"},{"key":"e_1_3_2_221_2","first-page":"130","volume":"17","year":"2009","unstructured":"Nesic, D., M. C. Miller, Z. T. Quinkert, M. Stein, B. T. Chait, and C. E. Stebbins. 2009. Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates. Nat. Struct. Mol. Biol.17:130-132.","journal-title":"Nat. Struct. Mol. Biol."},{"key":"e_1_3_2_222_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.03081.x"},{"key":"e_1_3_2_223_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102901"},{"key":"e_1_3_2_224_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409096833"},{"key":"e_1_3_2_225_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.3.567"},{"key":"e_1_3_2_226_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2002.tb01209.x"},{"key":"e_1_3_2_227_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.6.1111"},{"key":"e_1_3_2_228_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1497"},{"key":"e_1_3_2_229_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-03-0283"},{"key":"e_1_3_2_230_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.11.062"},{"key":"e_1_3_2_231_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00887-09"},{"key":"e_1_3_2_232_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.105"},{"key":"e_1_3_2_233_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407657102"},{"key":"e_1_3_2_234_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711183105"},{"key":"e_1_3_2_235_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000603"},{"key":"e_1_3_2_236_2","doi-asserted-by":"publisher","DOI":"10.1086\/604727"},{"key":"e_1_3_2_237_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01307.x"},{"key":"e_1_3_2_238_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.4.1984-1990.2002"},{"key":"e_1_3_2_239_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200301000-00002"},{"key":"e_1_3_2_240_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.21.9720"},{"key":"e_1_3_2_241_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2764"},{"key":"e_1_3_2_242_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_3_2_243_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.3.297"},{"key":"e_1_3_2_244_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.7950"},{"key":"e_1_3_2_245_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc703"},{"key":"e_1_3_2_246_2","first-page":"6124","volume":"59","year":"1999","unstructured":"Peek, R. M., Jr., M. J. Blaser, D. J. Mays, M. H. Forsyth, T. L. Cover, S. Y. Song, U. Krishna, and J. A. Pietenpol. 1999. Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle. Cancer Res.59:6124-6131.","journal-title":"Cancer Res."},{"key":"e_1_3_2_247_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1868"},{"key":"e_1_3_2_248_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.1.28-32.1995"},{"key":"e_1_3_2_249_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01284.x"},{"key":"e_1_3_2_250_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.5.1557-1565.1994"},{"key":"e_1_3_2_251_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090683"},{"key":"e_1_3_2_252_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003819200"},{"key":"e_1_3_2_253_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)80113-X"},{"key":"e_1_3_2_254_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062060"},{"key":"e_1_3_2_255_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981005)78:2<135::AID-IJC1>3.0.CO;2-#"},{"key":"e_1_3_2_256_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.05.001"},{"key":"e_1_3_2_257_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02177.x"},{"key":"e_1_3_2_258_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.6.642"},{"key":"e_1_3_2_259_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606172200"},{"key":"e_1_3_2_260_2","doi-asserted-by":"publisher","DOI":"10.1038\/86373"},{"key":"e_1_3_2_261_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-9521(04)00089-8"},{"key":"e_1_3_2_262_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.056"},{"key":"e_1_3_2_263_2","first-page":"1276","volume":"57","year":"1997","unstructured":"Ristimaki, A., N. Honkanen, H. Jankala, P. Sipponen, and M. Harkonen. 1997. Expression of cyclooxygenase-2 in human gastric carcinoma. Cancer Res.57:1276-1280.","journal-title":"Cancer Res."},{"key":"e_1_3_2_264_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1846"},{"key":"e_1_3_2_265_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1174"},{"key":"e_1_3_2_266_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.44.28560"},{"key":"e_1_3_2_267_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700719"},{"key":"e_1_3_2_268_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018849112533"},{"key":"e_1_3_2_269_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2808"},{"key":"e_1_3_2_270_2","first-page":"5500","volume":"58","year":"1998","unstructured":"Rudolph-Owen, L. A., R. Chan, W. J. Muller, and L. M. Matrisian. 1998. The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis. Cancer Res.58:5500-5506.","journal-title":"Cancer Res."},{"key":"e_1_3_2_271_2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1365-2613.2002.00234.x","volume":"83","year":"2002","unstructured":"Ruzsovics, A., Z. Unger, B. Molnar, L. Pronai, and Z. Tulassay. 2002. Effect of Helicobacter pylori infection on epidermal growth factor receptor (EGFR) expression and cell proliferation of gastric epithelial mucosa: correlation to macroscopic and microscopic diagnosis. Int. J. Exp. Pathol.83:257-263.","journal-title":"Int. J. Exp. Pathol."},{"key":"e_1_3_2_272_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05765"},{"key":"e_1_3_2_273_2","first-page":"519","volume":"148","year":"1996","unstructured":"Saarialho-Kere, U. K., M. Vaalamo, P. Puolakkainen, K. Airola, W. C. Parks, and M. L. Karjalainen-Lindsberg. 1996. Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers. Am. J. Pathol.148:519-526.","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_274_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00431.2007"},{"key":"e_1_3_2_275_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.4.611"},{"key":"e_1_3_2_276_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.03.003"},{"key":"e_1_3_2_277_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(98)90079-5"},{"key":"e_1_3_2_278_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-1-5"},{"key":"e_1_3_2_279_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01019.x"},{"key":"e_1_3_2_280_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.021"},{"key":"e_1_3_2_281_2","unstructured":"Reference deleted."},{"key":"e_1_3_2_282_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14559"},{"key":"e_1_3_2_283_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200400915"},{"key":"e_1_3_2_284_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg050"},{"key":"e_1_3_2_285_2","doi-asserted-by":"publisher","DOI":"10.1086\/368133"},{"key":"e_1_3_2_286_2","first-page":"313","volume":"16","year":"1998","unstructured":"Senota, A., F. Itoh, H. Yamamoto, Y. Adachi, Y. Hinoda, and K. Imai. 1998. Relation of matrilysin messenger RNA expression with invasive activity in human gastric cancer. Clin. Exp. Metastasis16:313-321.","journal-title":"Clin. Exp. Metastasis"},{"key":"e_1_3_2_287_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.11.003"},{"key":"e_1_3_2_288_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn276"},{"key":"e_1_3_2_289_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21822"},{"key":"e_1_3_2_290_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.3.225"},{"key":"e_1_3_2_291_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520119597"},{"key":"e_1_3_2_292_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70131-X"},{"key":"e_1_3_2_293_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.8200"},{"key":"e_1_3_2_294_2","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2003543"},{"key":"e_1_3_2_295_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02781.x"},{"key":"e_1_3_2_296_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.3.1263"},{"key":"e_1_3_2_297_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.1.19"},{"key":"e_1_3_2_298_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.11.3278-3288.1993"},{"key":"e_1_3_2_299_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01291.x"},{"key":"e_1_3_2_300_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i14.2174"},{"key":"e_1_3_2_301_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00227.x"},{"key":"e_1_3_2_302_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401528101"},{"key":"e_1_3_2_303_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64586-5"},{"key":"e_1_3_2_304_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280100430"},{"key":"e_1_3_2_305_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.11.010"},{"key":"e_1_3_2_306_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051027"},{"key":"e_1_3_2_307_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01237.x"},{"key":"e_1_3_2_308_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.765"},{"key":"e_1_3_2_309_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01456-08"},{"key":"e_1_3_2_310_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000407"},{"key":"e_1_3_2_311_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2008.01269.x"},{"key":"e_1_3_2_312_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2004.02.003"},{"key":"e_1_3_2_313_2","doi-asserted-by":"publisher","DOI":"10.1038\/41483"},{"key":"e_1_3_2_314_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19981029)78:3<298::AID-IJC6>3.0.CO;2-Q"},{"key":"e_1_3_2_315_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00266-X"},{"key":"e_1_3_2_316_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2005.00006.x"},{"key":"e_1_3_2_317_2","doi-asserted-by":"publisher","DOI":"10.1159\/000069310"},{"key":"e_1_3_2_318_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208155200"},{"key":"e_1_3_2_319_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.1.261-276.2006"},{"key":"e_1_3_2_320_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.10.011"},{"key":"e_1_3_2_321_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060681"},{"key":"e_1_3_2_322_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_3_2_323_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.035766"},{"key":"e_1_3_2_324_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70065-X"},{"key":"e_1_3_2_325_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.6.2239"},{"key":"e_1_3_2_326_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1131"},{"key":"e_1_3_2_327_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.7.3837-3843.2003"},{"key":"e_1_3_2_328_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199801000-00008"},{"key":"e_1_3_2_329_2","first-page":"562","volume":"138","year":"2009","unstructured":"Waghray, M., Y. Zavros, M. Saqui-Salces, M. El-Zaatari, C. B. Alamelumangapuram, A. Todisco, K. A. Eaton, and J. L. Merchant. 2009. Interleukin-1beta promotes gastric atrophy through suppression of sonic hedgehog. Gastroenterology138:562-572.","journal-title":"Gastroenterology"},{"key":"e_1_3_2_330_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70003-9"},{"key":"e_1_3_2_331_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00740-4"},{"key":"e_1_3_2_332_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800527200"},{"key":"e_1_3_2_333_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4303-4311.2000"},{"key":"e_1_3_2_334_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39481"},{"key":"e_1_3_2_335_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5452.482"},{"key":"e_1_3_2_336_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.07.015"},{"key":"e_1_3_2_337_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0095"},{"key":"e_1_3_2_338_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20344"},{"key":"e_1_3_2_339_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304131200"},{"key":"e_1_3_2_340_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119651"},{"key":"e_1_3_2_341_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1402"},{"key":"e_1_3_2_342_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(96)70014-8"},{"key":"e_1_3_2_343_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.49.35179"},{"key":"e_1_3_2_344_2","first-page":"4805","volume":"54","year":"1994","unstructured":"Witty, J. P., S. McDonnell, K. J. Newell, P. Cannon, M. Navre, R. J. Tressler, and L. M. Matrisian. 1994. Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo. Cancer Res.54:4805-4812.","journal-title":"Cancer Res."},{"key":"e_1_3_2_345_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.187"},{"key":"e_1_3_2_346_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01051.x"},{"key":"e_1_3_2_347_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.09.011"},{"key":"e_1_3_2_348_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.011"},{"key":"e_1_3_2_349_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200305000-00009"},{"key":"e_1_3_2_350_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0383"},{"key":"e_1_3_2_351_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2015"},{"key":"e_1_3_2_352_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.8.863"},{"key":"e_1_3_2_353_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3511"},{"key":"e_1_3_2_354_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.1.248-256.2006"},{"key":"e_1_3_2_355_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.12.048"},{"key":"e_1_3_2_356_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130079797"},{"key":"e_1_3_2_357_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.083014"},{"key":"e_1_3_2_358_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980417)79:2<187::AID-IJC15>3.0.CO;2-7"},{"key":"e_1_3_2_359_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.08.031"},{"key":"e_1_3_2_360_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.12.004"},{"key":"e_1_3_2_361_2","first-page":"348","volume":"22","year":"2002","unstructured":"Yao, Y. L., B. Xu, Y. G. Song, W. D. Zhang, Y. L. Zhang, and Z. S. Zhang. 2002. Effect of Helicobacter pylori infection on gastric mucosal cell proliferation in Mongolian gerbils. Di Yi Jun Yi Da Xue Xue Bao22:348-350, 365.","journal-title":"Di Yi Jun Yi Da Xue Xue Bao"},{"key":"e_1_3_2_362_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119325"},{"key":"e_1_3_2_363_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.925702"},{"key":"e_1_3_2_364_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.5.2630-2639.2002"},{"key":"e_1_3_2_365_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.01084.x"},{"key":"e_1_3_2_366_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04293.x"},{"key":"e_1_3_2_367_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00250.x"},{"key":"e_1_3_2_368_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117452"}],"container-title":["Clinical Microbiology Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CMR.00011-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CMR.00011-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T01:48:37Z","timestamp":1711849717000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CMR.00011-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":367,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1128\/CMR.00011-10"],"URL":"https:\/\/doi.org\/10.1128\/cmr.00011-10","relation":{},"ISSN":["0893-8512","1098-6618"],"issn-type":[{"value":"0893-8512","type":"print"},{"value":"1098-6618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"2010-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}