{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:55:09Z","timestamp":1793505309428,"version":"4.5.0"},"reference-count":288,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["Intramural Support"],"award-info":[{"award-number":["Intramural Support"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Microbiol Rev"],"published-print":{"date-parts":[[2019,9,18]]},"abstract":"<jats:p>\n            Protozoan\n            <jats:italic>Plasmodium<\/jats:italic>\n            parasites are the causative agents of malaria, a deadly disease that continues to afflict hundreds of millions of people every year. Infections with malaria parasites can be asymptomatic, with mild or severe symptoms, or fatal, depending on many factors such as parasite virulence and host immune status. Malaria can be treated with various drugs, with artemisinin-based combination therapies (ACTs) being the first-line choice.\n          <\/jats:p>","DOI":"10.1128\/cmr.00019-19","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T12:55:57Z","timestamp":1564491357000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":124,"title":["<i>Plasmodium<\/i>\n            Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution"],"prefix":"10.1128","volume":"32","author":[{"given":"Xin-zhuan","family":"Su","sequence":"first","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin D.","family":"Lane","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xia","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana M.","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Wellems","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61270-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394303-3.00010-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62566-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-262"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01099"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07306"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2375"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21038"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182016001335"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2359-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc2183"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001942"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0345-5"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025585"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70095-1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-397900-1.00002-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1590\/0074-0276130597"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026617666170130123520"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.50"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-1784-1"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.08.011"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4381"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4573"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2011.01340.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(03)00066-7"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07327"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01097"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-014-0086-0"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5754"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.218123.116"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.11864.1"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.9876.1"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2016.05.009"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.24.11373"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2002)088[0972:AMPOMP]2.0.CO;2"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2016.05.008"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02474-17"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005824"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3588"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu349"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2624"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003566"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11174"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.203711.115"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15194.2"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evx256"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.168286.113"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature24280"},{"key":"e_1_3_2_50_2","first-page":"23","article-title":"The genome of model malaria parasites, and comparative genomics","volume":"7","author":"Carlton J","year":"2005","unstructured":"Carlton J, Silva J, Hall N. 2005. The genome of model malaria parasites, and comparative genomics. Curr Issues Mol Biol 7:23\u201337.","journal-title":"Curr Issues Mol Biol"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0010044"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2006.03.023"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0218"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5443.1351"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01023-7"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2126"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04035.x"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80447-X"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2210-z"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00813"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12951-0"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.04.010"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.47"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.12.010"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0162-2"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.5.1585"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.159.6.1567"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90054-3"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90055-1"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90056-X"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.12.012"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix230"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025551"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03631"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711401105"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13401"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep23449"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005917"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.276"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12231"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj517"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2016.10.002"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.8.3017-3023.1997"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-018-0065-5"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2019.04.001"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2003.00643.x"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000853"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.07.008"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235264"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1520426112"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04801.x"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906387106"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3895435"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/315347a0"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90487-3"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90539-3"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(87)90144-7"},{"key":"e_1_3_2_98_2","first-page":"813","article-title":"Chromosome size variation occurs in cloned Plasmodium falciparum on in vitro cultivation","volume":"11","author":"Wellems T","year":"1988","unstructured":"Wellems T, Oduola AMJ, Fenton B, Desjardins R, Panton LJ, DoRosario VE. 1988. Chromosome size variation occurs in cloned Plasmodium falciparum on in vitro cultivation. Rev Brazilian Genetics 11:813\u2013825.","journal-title":"Rev Brazilian Genetics"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(88)90117-6"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90097-9"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/35039531"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(92)90081-T"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/345253a0"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.23.9114"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102261108"},{"key":"e_1_3_2_106_2","first-page":"253","volume-title":"Malaria: parasite biology, pathogenesis, and protection","author":"Su X-Z","year":"1998","unstructured":"Su X-Z, Wellems T. 1998. Genome discovery amd malaria research: current status and promise, p 253\u2013266. In Sherman IW (ed), Malaria: parasite biology, pathogenesis, and protection. American Society for Microbiology, Washington, DC."},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1997.4174"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.06.003"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.03.011"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1232502100"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00836"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1924"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1931"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1930"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(93)90252-S"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16767-6"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1086\/592451"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000243"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2009.04.005"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01793-10"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04388.x"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005091"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.7.2428"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060238"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000644"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-457"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msl185"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003375"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.16.6065"},{"key":"e_1_3_2_130_2","first-page":"53","article-title":"Chloroquine and acid vesicle function","volume":"313","author":"Krogstad DJ","year":"1989","unstructured":"Krogstad DJ, Schlesinger PH, Gluzman IY. 1989. Chloroquine and acid vesicle function. Prog Clin Biol Res 313:53\u201359.","journal-title":"Prog Clin Biol Res"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90330-9"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1038\/345255a0"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.47.2.709-718.2003"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01459-07"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05378.x"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3299700"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.06.001"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1813386115"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3432"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.12.7349"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(94)00199-W"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.05.002"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-577"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004382"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004085"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00077-8"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10606"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302045"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911317106"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048824"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05753.x"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2866205"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405097102"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00267-3"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-316"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030030"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2012.10.011"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(98)00021-8"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.02.003"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811430106"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2013.74"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.06.058"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316467111"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02161-16"},{"key":"e_1_3_2_165_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-12-r171"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.528"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001383"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02574-12"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096486"},{"key":"e_1_3_2_170_2","volume-title":"Saving lives, buying time: economics of malaria drugs in an age of resistance","author":"Institute of Medicine","year":"2004","unstructured":"Institute of Medicine. 2004. Saving lives, buying time: economics of malaria drugs in an age of resistance. Institute of Medicine, Washington, DC."},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(84)92057-9"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1992.47.794"},{"key":"e_1_3_2_173_2","first-page":"494","article-title":"Malaria in Vietnam. Environment, prevention and treatment","volume":"86","author":"Nguyen TA","year":"1993","unstructured":"Nguyen TA. 1993. Malaria in Vietnam. Environment, prevention and treatment. Bull Soc Pathol Exot 86:494\u2013499.","journal-title":"Bull Soc Pathol Exot"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.8.3018"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101253440403"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.EI10-0013-2016"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30414-5"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2018021"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805011"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019283"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01868-12"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12876"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc091737"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00044-12"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis958"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057689"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70252-4"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215966"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211205110"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3189"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.05.010"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.12-0388"},{"key":"e_1_3_2_195_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.04.001"},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.05.002"},{"key":"e_1_3_2_197_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00481-15"},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw584"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01426-18"},{"key":"e_1_3_2_201_2","volume-title":"Status report on artemisinin and artemisinin-based combination therapy resistance","author":"World Health Organization Global Malaria Programme","year":"2017","unstructured":"World Health Organization Global Malaria Programme. 2017. Status report on artemisinin and artemisinin-based combination therapy resistance. WHO, Geneva, Switzerland."},{"key":"e_1_3_2_202_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0874-1"},{"key":"e_1_3_2_203_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02902-14"},{"key":"e_1_3_2_204_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03055-14"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70049-6"},{"key":"e_1_3_2_206_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00686-12"},{"key":"e_1_3_2_207_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05652-0"},{"key":"e_1_3_2_209_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30409-1"},{"key":"e_1_3_2_210_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00487-9"},{"key":"e_1_3_2_211_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30415-7"},{"key":"e_1_3_2_212_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05163-14"},{"key":"e_1_3_2_213_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw229"},{"key":"e_1_3_2_214_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2007.07.007"},{"key":"e_1_3_2_215_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm400325j"},{"key":"e_1_3_2_216_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-2724-z"},{"key":"e_1_3_2_217_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.07.010"},{"key":"e_1_3_2_218_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.009"},{"key":"e_1_3_2_219_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00008-09"},{"key":"e_1_3_2_220_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098876"},{"key":"e_1_3_2_221_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msg162"},{"key":"e_1_3_2_222_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.02.010"},{"key":"e_1_3_2_223_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00623-08"},{"key":"e_1_3_2_224_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000830"},{"key":"e_1_3_2_225_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msu106"},{"key":"e_1_3_2_226_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00015-5"},{"key":"e_1_3_2_227_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.216"},{"key":"e_1_3_2_228_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb300326z"},{"key":"e_1_3_2_229_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2006.07.032"},{"key":"e_1_3_2_230_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.215"},{"key":"e_1_3_2_231_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1205216"},{"key":"e_1_3_2_232_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.10.005"},{"key":"e_1_3_2_233_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060840"},{"key":"e_1_3_2_234_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.01.004"},{"key":"e_1_3_2_235_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193225"},{"key":"e_1_3_2_236_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-2-r21"},{"key":"e_1_3_2_237_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.04.015"},{"key":"e_1_3_2_238_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804492115"},{"key":"e_1_3_2_239_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08180.x"},{"key":"e_1_3_2_240_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812317115"},{"key":"e_1_3_2_241_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4472"},{"key":"e_1_3_2_242_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214023"},{"key":"e_1_3_2_243_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.12.039"},{"key":"e_1_3_2_244_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1614-3"},{"key":"e_1_3_2_245_2","doi-asserted-by":"publisher","DOI":"10.1038\/414751a"},{"key":"e_1_3_2_246_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.04.002"},{"key":"e_1_3_2_247_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002992"},{"key":"e_1_3_2_248_2","doi-asserted-by":"publisher","DOI":"10.1038\/76272"},{"key":"e_1_3_2_249_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2011.05178.x"},{"key":"e_1_3_2_250_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(03)00173-4"},{"key":"e_1_3_2_251_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.24.13040"},{"key":"e_1_3_2_252_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.8.4425"},{"key":"e_1_3_2_253_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(00)00313-3"},{"key":"e_1_3_2_254_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059878"},{"key":"e_1_3_2_255_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/150.1.511"},{"key":"e_1_3_2_256_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2001.1759"},{"key":"e_1_3_2_257_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09442"},{"key":"e_1_3_2_258_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evw128"},{"key":"e_1_3_2_259_2","doi-asserted-by":"publisher","DOI":"10.1111\/mec.14066"},{"key":"e_1_3_2_260_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802328105"},{"key":"e_1_3_2_261_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/158.4.1505"},{"key":"e_1_3_2_262_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30068-9"},{"key":"e_1_3_2_263_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3599"},{"key":"e_1_3_2_264_2","unstructured":"WHO. 2018. World malaria report. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/275867\/9789241565653-eng.pdf?ua=1."},{"key":"e_1_3_2_265_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006035"},{"key":"e_1_3_2_266_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003776107"},{"key":"e_1_3_2_267_2","doi-asserted-by":"publisher","DOI":"10.1179\/2047773215Y.0000000014"},{"key":"e_1_3_2_268_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2373"},{"key":"e_1_3_2_269_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msi160"},{"key":"e_1_3_2_270_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409652102"},{"key":"e_1_3_2_271_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15836-4"},{"key":"e_1_3_2_272_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy519"},{"key":"e_1_3_2_273_2","first-page":"55","article-title":"Evolution of Plasmodium and the recent origin of the world populations of Plasmodium falciparum","volume":"41","author":"Ayala FJ","year":"1999","unstructured":"Ayala FJ, Escalante AA, Rich SM. 1999. Evolution of Plasmodium and the recent origin of the world populations of Plasmodium falciparum. Parassitologia 41:55\u201368.","journal-title":"Parassitologia"},{"key":"e_1_3_2_274_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0606-6"},{"key":"e_1_3_2_275_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30333-9"},{"key":"e_1_3_2_276_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(03)00070-9"},{"key":"e_1_3_2_277_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.17-0461"},{"key":"e_1_3_2_278_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2018.02.006"},{"key":"e_1_3_2_279_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4346"},{"key":"e_1_3_2_280_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43831-1"},{"key":"e_1_3_2_281_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.2.373"},{"key":"e_1_3_2_282_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002882"},{"key":"e_1_3_2_283_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01888-17"},{"key":"e_1_3_2_284_2","doi-asserted-by":"publisher","DOI":"10.1086\/512242"},{"key":"e_1_3_2_285_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.178129"},{"key":"e_1_3_2_286_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.08.013"},{"key":"e_1_3_2_287_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-3183-3"},{"key":"e_1_3_2_288_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-128"},{"key":"e_1_3_2_289_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2005.3232"},{"key":"e_1_3_2_290_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0814-0"},{"key":"e_1_3_2_291_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0333-6"}],"container-title":["Clinical Microbiology Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CMR.00019-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CMR.00019-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T12:56:18Z","timestamp":1645620978000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CMR.00019-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,18]]},"references-count":288,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,9,18]]}},"alternative-id":["10.1128\/CMR.00019-19"],"URL":"https:\/\/doi.org\/10.1128\/cmr.00019-19","relation":{},"ISSN":["0893-8512","1098-6618"],"issn-type":[{"value":"0893-8512","type":"print"},{"value":"1098-6618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,18]]},"assertion":[{"value":"2019-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00019-19"}}