{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:08:06Z","timestamp":1792649286317,"version":"4.5.0"},"reference-count":351,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Microbiol Rev"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:sec>\n                    <jats:title>SUMMARY<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Shigella<\/jats:italic>\n                      spp. are gram-negative pathogenic bacteria that evolved from harmless enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research performed over the last 25 years revealed that a type III secretion system (T3SS) encoded on a large plasmid is a key virulence factor of\n                      <jats:italic>Shigella flexneri<\/jats:italic>\n                      . The T3SS determines the interactions of\n                      <jats:italic>S. flexneri<\/jats:italic>\n                      with intestinal cells by consecutively translocating two sets of effector proteins into the target cells. Thus,\n                      <jats:italic>S. flexneri<\/jats:italic>\n                      controls invasion into EC, intra- and intercellular spread, macrophage cell death, as well as host inflammatory responses. Some of the translocated effector proteins show novel biochemical activities by which they intercept host cell signal transduction pathways. An understanding of the molecular mechanisms underlying\n                      <jats:italic>Shigella<\/jats:italic>\n                      pathogenesis will foster the development of a safe and efficient vaccine, which, in parallel with improved hygiene, should curb infections by this widespread pathogen.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/cmr.00032-07","type":"journal-article","created":{"date-parts":[[2008,1,17]],"date-time":"2008-01-17T19:57:54Z","timestamp":1200599874000},"page":"134-156","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":558,"title":["Molecular Pathogenesis of\n                    <i>Shigella<\/i>\n                    spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion"],"prefix":"10.1128","volume":"21","author":[{"given":"Gunnar N.","family":"Schroeder","sequence":"first","affiliation":[{"name":"Institute of Microbiology, ETH Zu\u0308rich, Wolfgang Pauli Strasse 10, 8093 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Hilbi","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, ETH Zu\u0308rich, Wolfgang Pauli Strasse 10, 8093 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crvi.2005.02.008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1989.tb00210.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03992"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0968-0004(03)00167-1","volume":"28","year":"2003","unstructured":"Alder, N. N., and S. M. Theg. 2003. Energy use by biological protein transport pathways. Trends Biochem. Sci.28:442-451.","journal-title":"Trends Biochem. Sci."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.5.2457-2463.2000"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.5.1707-1714.1993"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb00885.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.mmi_17030461.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01097.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.23.7661-7669.1992"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.13.3722-3726.1996"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.10.031"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.5.1463"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1423"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1365-2958.2006.05547.x","volume":"63","year":"2007","unstructured":"Ashida, H., T. Toyotome, T. Nagai, and C. Sasakawa. 2007. Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors. Mol. Microbiol.63:680-693.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.02.008"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.10.4005-4010.1997"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.5.1599-1605.1997"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00242-4"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.mmi_17010123.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2005.07.008"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.10.3867"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.3.683"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02200.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0535335100"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00051-0"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(03)00037-0"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.21.5853"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.02179.x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.02.006"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.6.2561-2569.1987"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00198.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(02)02343-0"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1373520"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00759.x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(03)00761-4"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.58.030603.123630"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01866-06"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.3.521-527.1987"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.09.062"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300091200"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1526"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090124"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(98)00213-1"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.12.7471-7480.2001"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602689103"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00617.x"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(96)01379-8"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207107"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:APPT.0000031448.64969.fa"},{"key":"e_1_3_2_53_2","doi-asserted-by":"crossref","first-page":"39534","DOI":"10.1074\/jbc.M605939200","volume":"281","year":"2006","unstructured":"Demali, K. A., A. L. Jue, and K. Burridge. 2006. IpaA targets beta 1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry. J. Biol. Chem.281:39534-39541.","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.10.2894"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400326101"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.05.019"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2003.10.002"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro884"},{"key":"e_1_3_2_59_2","first-page":"1933","volume":"128","year":"1982","unstructured":"Dodd, C. E. R., and D. Jones. 1982. A numerical taxonomic study of the genus Shigella. J. Gen. Microbiol.128:1933-1957.","journal-title":"J. Gen. Microbiol."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4221-00105"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00902.x"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611496104"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/159.6.1126"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200205)32:5<1464::AID-IMMU1464>3.0.CO;2-G"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.2871652.x"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.146.6.1319"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.07.069"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msh118"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-003-2460-3"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00440-06"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.57.6.633-638.1949"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.4.505"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117991"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(03)00042-9"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3608-3619.2000"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.3877"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80754-0"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9084(88)90271-4"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02714.x"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1412"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.8.2779-2785.2002"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00181.x"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5404.978"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.68.4.771-795.2004"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084677"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.8.2189-2196.1993"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6572"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.08.003"},{"key":"e_1_3_2_89_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.imlet.2005.11.021","volume":"104","year":"2006","unstructured":"Gombos, I., E. Kiss, C. Detre, G. Laszlo, and J. Matko. 2006. Cholesterol and sphingolipids as lipid organizers of the immune cells' plasma membrane: their impact on the functions of MHC molecules, effector T-lymphocytes and T-cell death. Immunol. Lett.104:59-69.","journal-title":"Immunol. Lett."},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.1.364-367.1993"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2004.12.013"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.60.080805.142251"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5297.206"},{"key":"e_1_3_2_94_2","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1002\/j.1460-2075.1995.tb07184.x","volume":"14","year":"1995","unstructured":"Gu, Y., J. Wu, C. Faucheu, J. L. Lalanne, A. Diu, D. J. Livingston, and M. S. Su. 1995. Interleukin-1\u03b2 converting enzyme requires oligomerization for activity of processed forms in vivo. EMBO J.14:1923-1931.","journal-title":"EMBO J."},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.4.1269-1276.2001"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.033"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.08.002"},{"key":"e_1_3_2_98_2","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/sj.embor.7400753","volume":"7","year":"2006","unstructured":"Hamiaux, C., A. van Eerde, C. Parsot, J. Broos, and B. W. Dijkstra. 2006. Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri. EMBO Rep.7:794-799.","journal-title":"EMBO Rep."},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01479-06"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1925"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1526"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0512593"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.3.1255-1264.2003"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.4.1905-1915.1990"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04568.x"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2004.0181.x"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.11.5587-5596.1999"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05253.x"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00793.x"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-199906000-00011"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.12.5165-5170.1997"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.49.32895"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.5502-5508.2000"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00641.x"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.57.10.2963-2970.1989"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(97)00143-1"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03559.x"},{"key":"e_1_3_2_118_2","first-page":"49","volume":"264","year":"2002","unstructured":"Ingersoll, M., E. A. Groisman, and A. Zychlinsky. 2002. Pathogenicity islands of Shigella. Curr. Top. Microbiol. Immunol.264:49-65.","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00320.x"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.4.2317-2327.2006"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/84627"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.2.739-749.1997"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.57.10.2912-2917.1991"},{"key":"e_1_3_2_124_2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1083\/jcb.200605091","volume":"175","year":"2006","unstructured":"Izard, T., G. Tran Van Nhieu, and P. R. Bois. 2006. Shigella applies molecular mimicry to subvert vinculin and invade host cells. J. Cell Biol.175:465-475.","journal-title":"J. Cell Biol."},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.083001.084359"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsre.2003.07.002"},{"key":"e_1_3_2_127_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.plasmid.2005.03.002","volume":"54","year":"2005","unstructured":"Jiang, Y., F. Yang, X. Zhang, J. Yang, L. Chen, Y. Yan, H. Nie, Z. Xiong, J. Wang, J. Dong, Y. Xue, X. Xu, Y. Zhu, S. Chen, and Q. Jin. 2005. The complete sequence and analysis of the large virulence plasmid pSS of Shigella sonnei. Plasmid54:149-159.","journal-title":"Plasmid"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf566"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607945200"},{"key":"e_1_3_2_130_2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1046\/j.1365-2958.2003.03590.x","volume":"49","year":"2003","unstructured":"Jouihri, N., M. P. Sory, A. L. Page, P. Gounon, C. Parsot, and A. Allaoui. 2003. MxiK and MxiN interact with the Spa47 ATPase and are required for transit of the needle components MxiH and MxiI, but not of Ipa proteins, through the type III secretion apparatus of Shigella flexneri. Mol. Microbiol.49:755-767.","journal-title":"Mol. Microbiol."},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.16.4409-4419.2002"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.57.5.1391-1398.1989"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508377200"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504466102"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro865"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324582"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2003.00118.x"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.504-513.2005"},{"key":"e_1_3_2_139_2","first-page":"651","volume":"77","year":"1999","unstructured":"Kotloff, K. L., J. P. Winickoff, B. Ivanoff, J. D. Clemens, D. L. Swerdlow, P. J. Sansonetti, G. K. Adak, and M. M. Levine. 1999. Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull. W. H. O.77:651-666.","journal-title":"Bull. W. H. O."},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030021"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5363.602"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402060"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103831200"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf457"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00515.x"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5080-5088.2004"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6303-6309.2001"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01637-4"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2003.08.010"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1735"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27639-0"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.171.1.353-359.1989"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138960"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609009103"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.Supplement_4.S279"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6012-6021.2001"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.13.3433-3441.2002"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90880-9"},{"key":"e_1_3_2_160_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2567.2004.01964.x","volume":"113","year":"2004","unstructured":"Man, A. L., M. E. Prieto-Garcia, and C. Nicoletti. 2004. Improving M cell-mediated transport across mucosal barriers: do certain bacteria hold the keys? Immunology113:15-22.","journal-title":"Immunology"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.1.110-115.1997"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1129"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1997"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"e_1_3_2_165_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402038"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.06.004"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2006.00526.x"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.49.1.164-171.1985"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3943"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02836.x"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.24.6751-6759.2002"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.9.4237-4243.1998"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06863.x"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.175.18.5899-5906.1993"},{"key":"e_1_3_2_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90260-7"},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.5.2587-2595.2006"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2001.00143.x"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00665-7"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509644200"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01449.x"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112.13.2069"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.1.237-248.1992"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01707.x"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.17.5062-5069.1995"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.9.1963-1969.1987"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.12.4721-4728.1995"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2000.00056.x"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408410490499872"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-173"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf522"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.02041.x"},{"key":"e_1_3_2_192_2","first-page":"133","volume":"43","year":"2005","unstructured":"Niyogi, S. K. 2005. Shigellosis. J. Microbiol.43:133-143.","journal-title":"J. Microbiol."},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.53.1.57-63.1986"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.1038\/35012500"},{"key":"e_1_3_2_195_2","first-page":"2715","volume":"129","year":"1983","unstructured":"Ochman, H., T. Whittam, D. A. Caugant, and R. K. Selander. 1983. Enzyme polymorphism and genetic population structure in Escherichia coli and Shigella. J. Gen. Microbiol.129:2715-2726.","journal-title":"J. Gen. Microbiol."},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00652.x"},{"key":"e_1_3_2_197_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03489.x"},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106036"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502509200"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.05.145"},{"key":"e_1_3_2_201_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01599-06"},{"key":"e_1_3_2_202_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(01)01405-8"},{"key":"e_1_3_2_203_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02654.x"},{"key":"e_1_3_2_204_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.1999.00019.x"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.03138.x"},{"key":"e_1_3_2_206_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.02835.x"},{"key":"e_1_3_2_207_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2004.tb09768.x"},{"key":"e_1_3_2_208_2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev.immunol.25.022106.141656","volume":"25","year":"2007","unstructured":"Park, H. H., Y. C. Lo, S. C. Lin, L. Wang, J. K. Yang, and H. Wu. 2007. The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu. Rev. Immunol.25:561-586.","journal-title":"Annu. Rev. Immunol."},{"key":"e_1_3_2_209_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2005.08.046"},{"key":"e_1_3_2_210_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04645.x"},{"key":"e_1_3_2_211_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(02)00002-4"},{"key":"e_1_3_2_212_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2003.00128.x"},{"key":"e_1_3_2_213_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-005-4577-x"},{"key":"e_1_3_2_214_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303749200"},{"key":"e_1_3_2_215_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601001"},{"key":"e_1_3_2_216_2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/1471-2164-7-218","volume":"7","year":"2006","unstructured":"Peng, J., X. Zhang, J. Yang, J. Wang, E. Yang, W. Bin, C. Wei, M. Sun, and Q. Jin. 2006. The use of comparative genomic hybridization to characterize genome dynamics and diversity among the serotypes of Shigella. BMC Genomics7:218.","journal-title":"BMC Genomics"},{"key":"e_1_3_2_217_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117015"},{"key":"e_1_3_2_218_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.4.1307"},{"key":"e_1_3_2_219_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb7100025"},{"key":"e_1_3_2_220_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.3.769"},{"key":"e_1_3_2_221_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.2.903"},{"key":"e_1_3_2_222_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02210.x"},{"key":"e_1_3_2_223_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1432-1440.2005"},{"key":"e_1_3_2_224_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004380050550"},{"key":"e_1_3_2_225_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.13.4187-4191.1994"},{"key":"e_1_3_2_226_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2508(02)01346-3"},{"key":"e_1_3_2_227_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00525-07"},{"key":"e_1_3_2_228_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/006916-0"},{"key":"e_1_3_2_229_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.7.2685-2692.1997"},{"key":"e_1_3_2_230_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.180094797"},{"key":"e_1_3_2_231_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.14.4176-4182.2001"},{"key":"e_1_3_2_232_2","first-page":"3670","volume":"197","year":"1997","unstructured":"Radnedge, L., M. A. Davis, B. L. Youngren, and S. J. Austin. 1997. Plasmid maintenance functions of the large virulence plasmid of Shigella flexneri. J. Bacteriol.197:3670-3675.","journal-title":"J. Bacteriol."},{"key":"e_1_3_2_233_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00795.x"},{"key":"e_1_3_2_234_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01681"},{"key":"e_1_3_2_235_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.01.057"},{"key":"e_1_3_2_236_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2004.09.002"},{"key":"e_1_3_2_237_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.19.3375"},{"key":"e_1_3_2_238_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01770.x"},{"key":"e_1_3_2_239_2","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1016\/j.febslet.2006.08.033","volume":"580","year":"2006","unstructured":"Reig, N., and F. G. van der Goot. 2006. About lipids and toxins. FEBS Lett.580:5572-5579.","journal-title":"FEBS Lett."},{"key":"e_1_3_2_240_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.02.002"},{"key":"e_1_3_2_241_2","first-page":"897","volume":"5","year":"2004","unstructured":"Riedl, S. J., and Y. Shi. 2004. Molecular mechanisms of caspase regulation during apoptosis. Nat. Rev. Mol. Cell Biol.5:897-907.","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"e_1_3_2_242_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4157(98)00019-7"},{"key":"e_1_3_2_243_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02552.x"},{"key":"e_1_3_2_244_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-144-9-2667"},{"key":"e_1_3_2_245_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1104"},{"key":"e_1_3_2_246_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00197.x"},{"key":"e_1_3_2_247_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1988.tb00067.x"},{"key":"e_1_3_2_248_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3780-3783.2000"},{"key":"e_1_3_2_249_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micron.2006.04.007"},{"key":"e_1_3_2_250_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2006.10.007"},{"key":"e_1_3_2_251_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2001.tb00569.x"},{"key":"e_1_3_2_252_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030354"},{"key":"e_1_3_2_253_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1499"},{"key":"e_1_3_2_254_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.7.2752-2764.1996"},{"key":"e_1_3_2_255_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118135"},{"key":"e_1_3_2_256_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.3.1471-1480.1999"},{"key":"e_1_3_2_257_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.39.3.1392-1402.1983"},{"key":"e_1_3_2_258_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.35.3.852-860.1982"},{"key":"e_1_3_2_259_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0882-4010(87)90037-4","volume":"3","year":"1987","unstructured":"Sansonetti, P. J., and J. Mounier. 1987. Metabolic events mediating early killing of host cells infected by Shigella flexneri. Microb. Pathog.3:53-61.","journal-title":"Microb. Pathog."},{"key":"e_1_3_2_260_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80209-5"},{"key":"e_1_3_2_261_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.51.2.461-469.1986"},{"key":"e_1_3_2_262_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.4.1620-1627.2006"},{"key":"e_1_3_2_263_2","first-page":"470","volume":"54","year":"1986","unstructured":"Sasakawa, C., K. Kamata, T. Sakai, S. Y. Murayama, S. Makino, and M. Yoshikawa. 1986. Molecular alteration of the 140-megadalton plasmid associated with loss of virulence and Congo red binding activity in Shigella flexneri. Infect. Immun.54:470-475.","journal-title":"Infect. Immun."},{"key":"e_1_3_2_264_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.170.6.2480-2484.1988"},{"key":"e_1_3_2_265_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.8.2334-2346.1993"},{"key":"e_1_3_2_266_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.54.1.32-36.1986"},{"key":"e_1_3_2_267_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.8.2768-2773.2005"},{"key":"e_1_3_2_268_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.9.2416-2421.2000"},{"key":"e_1_3_2_269_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.12.006"},{"key":"e_1_3_2_270_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.1.14-56.2004"},{"key":"e_1_3_2_271_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"e_1_3_2_272_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00787.x"},{"key":"e_1_3_2_273_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/007427-0"},{"key":"e_1_3_2_274_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.4.1982-1991.1999"},{"key":"e_1_3_2_275_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.24.6991-6998.2001"},{"key":"e_1_3_2_276_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.4.2180-2189.2001"},{"key":"e_1_3_2_277_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01627.x"},{"key":"e_1_3_2_278_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402026"},{"key":"e_1_3_2_279_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsre.2004.07.001"},{"key":"e_1_3_2_280_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni905"},{"key":"e_1_3_2_281_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.6056-6061.2000"},{"key":"e_1_3_2_282_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.4681827.x"},{"key":"e_1_3_2_283_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.007"},{"key":"e_1_3_2_284_2","first-page":"790","volume":"25","year":"1897","unstructured":"Shiga, K. 1897. Sekiri byogen kenkyu hokoku dai-ichi (first report on etiologic research on dysentery). Saikingaku Zasshi25:790-810.","journal-title":"Saikingaku Zasshi"},{"key":"e_1_3_2_285_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1809"},{"key":"e_1_3_2_286_2","doi-asserted-by":"publisher","DOI":"10.1038\/42408"},{"key":"e_1_3_2_287_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1721"},{"key":"e_1_3_2_288_2","doi-asserted-by":"publisher","DOI":"10.1038\/35036052"},{"key":"e_1_3_2_289_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.32.110601.141803"},{"key":"e_1_3_2_290_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.4197"},{"key":"e_1_3_2_291_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2000.00028.x"},{"key":"e_1_3_2_292_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605974103"},{"key":"e_1_3_2_293_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bbrc.2006.05.141","volume":"346","year":"2006","unstructured":"Stavropoulou, V., V. Vasquez, B. Cereser, E. Freda, and M. G. Masucci. 2006. TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints. Biochem. Biophys. Res. Commun.346:415-425.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"e_1_3_2_294_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01356.x"},{"key":"e_1_3_2_295_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1320"},{"key":"e_1_3_2_296_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1747"},{"key":"e_1_3_2_297_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030111"},{"key":"e_1_3_2_298_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.10.2767"},{"key":"e_1_3_2_299_2","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1084\/jem.191.11.1905","volume":"191","year":"2000","unstructured":"Suzuki, T., H. Mimuro, H. Miki, T. Takenawa, T. Sasaki, H. Nakanishi, Y. Takai, and C. Sasakawa. 2000. Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells. J. Exp. Med.191:1905-1920.","journal-title":"J. Exp. Med."},{"key":"e_1_3_2_300_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00185.x"},{"key":"e_1_3_2_301_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414671200"},{"key":"e_1_3_2_302_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.36.21878"},{"key":"e_1_3_2_303_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.15.3876"},{"key":"e_1_3_2_304_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.5.1244-1252.2002"},{"key":"e_1_3_2_305_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2004.00432.x"},{"key":"e_1_3_2_306_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115816"},{"key":"e_1_3_2_307_2","doi-asserted-by":"publisher","DOI":"10.1038\/356768a0"},{"key":"e_1_3_2_308_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1312"},{"key":"e_1_3_2_309_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1991.tb00762.x"},{"key":"e_1_3_2_310_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.175.19.6142-6149.1993"},{"key":"e_1_3_2_311_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.12.4295-4302.2005"},{"key":"e_1_3_2_312_2","first-page":"89","volume":"46","year":"2004","unstructured":"Torres, A. G. 2004. Current aspects of Shigella pathogenesis. Rev. Latinoam. Microbiol.46:89-97.","journal-title":"Rev. Latinoam. Microbiol."},{"key":"e_1_3_2_313_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101882200"},{"key":"e_1_3_2_314_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2004.12.006"},{"key":"e_1_3_2_315_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.10.2717"},{"key":"e_1_3_2_316_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.12.3249"},{"key":"e_1_3_2_317_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.727-734.2003"},{"key":"e_1_3_2_318_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.19.5535-5543.2001"},{"key":"e_1_3_2_319_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406824200"},{"key":"e_1_3_2_320_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400144"},{"key":"e_1_3_2_321_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05620.x"},{"key":"e_1_3_2_322_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1991.tb02089.x"},{"key":"e_1_3_2_323_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.174.6.1990-2001.1992"},{"key":"e_1_3_2_324_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.5.3271-3285.2001"},{"key":"e_1_3_2_325_2","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.5.5.669"},{"key":"e_1_3_2_326_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01448.x"},{"key":"e_1_3_2_327_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030353"},{"key":"e_1_3_2_328_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80943-5"},{"key":"e_1_3_2_329_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.57.3.858-863.1989"},{"key":"e_1_3_2_330_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.991"},{"key":"e_1_3_2_331_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07243.x"},{"key":"e_1_3_2_332_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.4.1342-1348.1998"},{"key":"e_1_3_2_333_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2775-2786.2003"},{"key":"e_1_3_2_334_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108472"},{"key":"e_1_3_2_335_2","first-page":"27","volume":"297","year":"2006","unstructured":"Wilharm, G., S. Dittmann, A. Schmid, and J. Heesemann. 2006. On the role of specific chaperones, the specific ATPase, and the proton motive force in type III secretion. Int. J. Med. Microbiol.297:27-36.","journal-title":"Int. J. Med. Microbiol."},{"key":"e_1_3_2_336_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.7.4004-4009.2004"},{"key":"e_1_3_2_337_2","doi-asserted-by":"publisher","DOI":"10.1038\/370270a0"},{"key":"e_1_3_2_338_2","unstructured":"Global burden of disease (GBD) 2002 estimates. 2004"},{"key":"e_1_3_2_339_2","unstructured":"Initiative for vaccine research (IVR). 2006"},{"key":"e_1_3_2_340_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki954"},{"key":"e_1_3_2_341_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-006-0052-8"},{"key":"e_1_3_2_342_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1133174"},{"key":"e_1_3_2_343_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf319"},{"key":"e_1_3_2_344_2","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4221-00179"},{"key":"e_1_3_2_345_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28141-0"},{"key":"e_1_3_2_346_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.5.3240-3247.2001"},{"key":"e_1_3_2_347_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3748\/wjg.v5.i3.245","volume":"5","year":"1999","unstructured":"Zhong, Q. P. 1999. Pathogenic effects of O-polysaccharide from Shigella flexneri strain. World J. Gastroenterol.5:245-248.","journal-title":"World J. Gastroenterol."},{"key":"e_1_3_2_348_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00594-06"},{"key":"e_1_3_2_349_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117452"},{"key":"e_1_3_2_350_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb00341.x"},{"key":"e_1_3_2_351_2","doi-asserted-by":"publisher","DOI":"10.1038\/358167a0"},{"key":"e_1_3_2_352_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.12.5357-5365.1996"}],"container-title":["Clinical Microbiology Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CMR.00032-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CMR.00032-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T05:45:20Z","timestamp":1708494320000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CMR.00032-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":351,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1128\/CMR.00032-07"],"URL":"https:\/\/doi.org\/10.1128\/cmr.00032-07","relation":{},"ISSN":["0893-8512","1098-6618"],"issn-type":[{"value":"0893-8512","type":"print"},{"value":"1098-6618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"2008-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}