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These syndromes are characterized by multiple metabolic dysfunctions including abnormal regulation of food reward and intake, energy storage, and low-grade inflammation. Given the increasing worldwide prevalence of obesity, cachexia, and associated metabolic disorders, novel therapeutic strategies are needed. Among the different mechanisms explaining how the gut microbiota is capable of influencing host metabolism and energy balance, numerous studies have investigated the complex interactions existing between nutrition, gut microbes, and their metabolites. In this review, we discuss how gut microbes and different microbiota-derived metabolites regulate host metabolism. We describe the role of the gut barrier function in the onset of inflammation in this context. We explore the importance of the gut-to-brain axis in the regulation of energy homeostasis and glucose metabolism but also the key role played by the liver. Finally, we present specific key examples of how using targeted approaches such as prebiotics and probiotics might affect specific metabolites, their signaling pathways, and their interactions with the host and reflect on the challenges to move from bench to bedside.<\/jats:p>","DOI":"10.1128\/cmr.00045-23","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T08:36:08Z","timestamp":1719563768000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":61,"title":["Role of the intestinal microbiota in contributing to weight disorders and associated comorbidities"],"prefix":"10.1128","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-107X","authenticated-orcid":false,"given":"Matthias","family":"Van Hul","sequence":"first","affiliation":[{"name":"UCLouvain, Universit\u00e9 catholique de Louvain, Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), Brussels, Belgium"},{"name":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), WELBIO department, WEL Research Institute, Wavre, Belgium"},{"name":"NeuroMicrobiota, International Research Program (IRP) INSERM\/UCLouvain, France\/Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey M.","family":"Neyrinck","sequence":"additional","affiliation":[{"name":"UCLouvain, Universit\u00e9 catholique de Louvain, Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Everard","sequence":"additional","affiliation":[{"name":"UCLouvain, Universit\u00e9 catholique de Louvain, Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), Brussels, Belgium"},{"name":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), WELBIO department, WEL Research Institute, Wavre, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Abot","sequence":"additional","affiliation":[{"name":"Enterosys SAS, Lab\u00e8ge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure B.","family":"Bindels","sequence":"additional","affiliation":[{"name":"UCLouvain, Universit\u00e9 catholique de Louvain, Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), Brussels, Belgium"},{"name":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), WELBIO department, WEL Research Institute, Wavre, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie M.","family":"Delzenne","sequence":"additional","affiliation":[{"name":"UCLouvain, Universit\u00e9 catholique de Louvain, Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Knauf","sequence":"additional","affiliation":[{"name":"NeuroMicrobiota, International Research Program (IRP) INSERM\/UCLouvain, France\/Belgium"},{"name":"INSERM U1220, Institut de Recherche en Sant\u00e9 Digestive (IRSD), Universit\u00e9 Paul Sabatier, Toulouse III, CHU Purpan, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2040-2448","authenticated-orcid":true,"given":"Patrice D.","family":"Cani","sequence":"additional","affiliation":[{"name":"UCLouvain, Universit\u00e9 catholique de Louvain, Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), Brussels, Belgium"},{"name":"Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), WELBIO department, WEL Research Institute, Wavre, Belgium"},{"name":"NeuroMicrobiota, International Research Program (IRP) INSERM\/UCLouvain, France\/Belgium"},{"name":"UCLouvain, Universit\u00e9 catholique de Louvain, Institute of Experimental and Clinical Research (IREC), Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"17","article-title":"Part 1: the human gut microbiome in health and disease","volume":"13","author":"Bull MJ","year":"2014","unstructured":"Bull MJ, Plummer NT. 2014. 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