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Almost 200 species of aspergilli have been identified, less than 20 of which are known to cause human disease. Among them,\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      is the most prevalent and is largely responsible for the increased incidence of invasive aspergillosis (IA) in the immunocompromised patient population. IA is a devastating illness, with mortality rates in some patient groups reaching as high as 90%. Studies identifying and assessing the roles of specific factors of\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      that contribute to the pathogenesis of IA have traditionally focused on single-gene deletion and mutant characterization. In combination with recent large-scale approaches analyzing global fungal responses to distinct environmental or host conditions, these studies have identified many factors that contribute to the overall pathogenic potential of\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      . Here, we provide an overview of the significant findings regarding\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      pathogenesis as it pertains to invasive disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/cmr.00055-08","type":"journal-article","created":{"date-parts":[[2009,7,13]],"date-time":"2009-07-13T15:53:01Z","timestamp":1247500381000},"page":"447-465","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":935,"title":["Pathogenesis of\n                    <i>Aspergillus fumigatus<\/i>\n                    in Invasive Aspergillosis"],"prefix":"10.1128","volume":"22","author":[{"given":"Taylor R. 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