{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:13:17Z","timestamp":1791486797409,"version":"4.3.4"},"reference-count":307,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Microbiol Rev"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Streptococcus pneumoniae<\/jats:named-content>\n            inflicts a huge disease burden as the leading cause of community-acquired pneumonia and meningitis. Soon after mainstream antibiotic usage, multiresistant pneumococcal clones emerged and disseminated worldwide. Resistant clones are generated through adaptation to antibiotic pressures imposed while naturally residing within the human upper respiratory tract. Here, a huge array of related commensal streptococcal strains transfers core genomic and accessory resistance determinants to the highly transformable pneumococcus. \u03b2-Lactam resistance is the hallmark of pneumococcal adaptability, requiring multiple independent recombination events that are traceable to nonpneumococcal origins and stably perpetuated in multiresistant clonal complexes. Pneumococcal strains with elevated MICs of \u03b2-lactams are most often resistant to additional antibiotics. Basic underlying mechanisms of most pneumococcal resistances have been identified, although new insights that increase our understanding are continually provided. Although all pneumococcal infections can be successfully treated with antibiotics, the available choices are limited for some strains. Invasive pneumococcal disease data compiled during 1998 to 2013 through the population-based Active Bacterial Core surveillance program (U.S. population base of 30,600,000) demonstrate that targeting prevalent capsular serotypes with conjugate vaccines (7-valent and 13-valent vaccines implemented in 2000 and 2010, respectively) is extremely effective in reducing resistant infections. Nonetheless, resistant non-vaccine-serotype clones continue to emerge and expand.\n          <\/jats:p>","DOI":"10.1128\/cmr.00058-15","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T03:18:49Z","timestamp":1460603929000},"page":"525-552","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":270,"title":["Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective"],"prefix":"10.1128","volume":"29","author":[{"given":"Lindsay","family":"Kim","sequence":"first","affiliation":[{"name":"Epidemiology Section, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"McGee","sequence":"additional","affiliation":[{"name":"Streptococcus Laboratory, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Tomczyk","sequence":"additional","affiliation":[{"name":"Epidemiology Section, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Beall","sequence":"additional","affiliation":[{"name":"Streptococcus Laboratory, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1202938"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60549-1"},{"key":"e_1_3_2_4_2","unstructured":"World Health Organization. 2014. Global immunization data. World Health Organization Geneva Switzerland. \nhttp:\/\/www.who.int\/immunization\/monitoring_surveillance\/global_immunization_data.pdf?ua=1\n. Accessed 17 September 2014."},{"key":"e_1_3_2_5_2","first-page":"1","article-title":"Recommendations of the Advisory Committee on Immunization Practices (ACIP): use of vaccines and immunoglobulins in persons with altered immunocompetence","volume":"42","author":"Centers for Disease Control and Prevention","year":"1993","unstructured":"Centers for Disease Control and Prevention. 1993. Recommendations of the Advisory Committee on Immunization Practices (ACIP): use of vaccines and immunoglobulins in persons with altered immunocompetence. MMWR Morb Mortal Wkly Rep 42:1\u201318.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_2_6_2","first-page":"1","article-title":"Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"46","author":"Centers for Disease Control and Prevention","year":"1997","unstructured":"Centers for Disease Control and Prevention. 1997. Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 46:1\u201324.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.13.1729"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69637-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/648593"},{"key":"e_1_3_2_10_2","first-page":"610","article-title":"Arzneifestigkeit bei Bakterien (Pneumokokken)","volume":"15","author":"Morgenroth J","year":"1912","unstructured":"Morgenroth J , Kaufmann M . 1912. Arzneifestigkeit bei Bakterien (Pneumokokken). Z Immunitatsforsch Exp Ther 15:610.","journal-title":"Z Immunitatsforsch Exp Ther"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1917.00080230114010"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)61900-1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1945.tb04075.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-53-14172P"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196509000-00003"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198901001-00020"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.2.256"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800054364"},{"key":"e_1_3_2_19_2","first-page":"1186","article-title":"Clinical and nasopharyngeal isolates of unusual multiply resistant pneumococci","volume":"140","author":"Klugman KP","year":"1986","unstructured":"Klugman KP , Koornhof HJ , Kuhnle V . 1986. Clinical and nasopharyngeal isolates of unusual multiply resistant pneumococci. Am J Dis Child 140:1186\u20131190.","journal-title":"Am J Dis Child"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/19.2.278"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.3.2.171"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.08.024"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197810052991402"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.1998.4.325"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.84"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.7.2565-2571.2001"},{"key":"e_1_3_2_27_2","volume-title":"Annual epidemiological report 2012: reporting on 2010 surveillance data and 2011 epidemic intelligence data","author":"European Centre for Disease Prevention and Control","year":"2013","unstructured":"European Centre for Disease Prevention and Control. 2013. Annual epidemiological report 2012: reporting on 2010 surveillance data and 2011 epidemic intelligence data. European Centre for Disease Prevention and Control, Solna, Sweden."},{"key":"e_1_3_2_28_2","volume-title":"Antibiotic resistance threats in the United States, 2013","author":"Centers for Disease Control and Prevention","year":"2014","unstructured":"Centers for Disease Control and Prevention. 2014. Antibiotic resistance threats in the United States, 2013. Centers for Disease Control and Prevention, Atlanta, GA."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/2047-2994-3-16"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(02)00127-9"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365549850160882"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.3.349.32105"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/322623"},{"key":"e_1_3_2_34_2","first-page":"194","article-title":"Bacteremia with Streptococcus pneumoniae. Implications for therapy and prevention","volume":"275","author":"Plouffe JF","year":"1996","unstructured":"Plouffe JF , Breiman RF , Facklam RR . 1996. Bacteremia with Streptococcus pneumoniae. Implications for therapy and prevention. Franklin County Pneumonia Study Group. JAMA 275:194\u2013198.","journal-title":"Franklin County Pneumonia Study Group. JAMA"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1086\/313716"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.90.2.223"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.01.010"},{"key":"e_1_3_2_38_2","volume-title":"CLSI document M100-S18","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Performance standards for antimicrobial susceptibility testing; eighteenth informational supplement. CLSI document M100-S18. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_39_2","first-page":"1353","article-title":"Effects of new penicillin susceptibility breakpoints for Streptococcus pneumoniae\u2014United States, 2006-2007","volume":"57","author":"Centers for Disease Control and Prevention","year":"2008","unstructured":"Centers for Disease Control and Prevention. 2008. Effects of new penicillin susceptibility breakpoints for Streptococcus pneumoniae\u2014United States, 2006-2007. MMWR Morb Mortal Wkly Rep 57:1353\u20131355.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02498-06"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02462-07"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.08.017"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00051-08"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.2.682-684.2002"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2005.04.005"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01574-05"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.1.457-460.2005"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2014.07.003"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004547"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evu120"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.08.027"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01310-13"},{"key":"e_1_3_2_53_2","first-page":"1647","article-title":"Resistant pneumococci: protecting patients through judicious use of antibiotics","volume":"55","author":"Dowell SF","year":"1997","unstructured":"Dowell SF , Schwartz B . 1997. Resistant pneumococci: protecting patients through judicious use of antibiotics. Am Fam Physician 55:1647\u20131654.","journal-title":"Am Fam Physician"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.3.e28"},{"key":"e_1_3_2_55_2","first-page":"1129","article-title":"Risk factors for antibiotic resistance in Streptococcus pneumoniae","volume":"97","author":"Klugman KP","year":"2007","unstructured":"Klugman KP . 2007. Risk factors for antibiotic resistance in Streptococcus pneumoniae . S Afr Med J 97:1129\u20131132.","journal-title":"S Afr Med J"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508243330803"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.04.066"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(98)00081-9"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100960050318"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1086\/514953"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1086\/514783"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.1.49"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.035675-0"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06463-11"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.5.884"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31824214ac"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.1.63"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46387-0"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1086\/513628"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-120"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01581-06"},{"key":"e_1_3_2_72_2","first-page":"1133","article-title":"Clinical significance of antimicrobial resistance in Streptococcus pneumoniae","volume":"97","author":"Jacobs MR","year":"2007","unstructured":"Jacobs MR . 2007. Clinical significance of antimicrobial resistance in Streptococcus pneumoniae . S Afr Med J 97:1133\u20131140.","journal-title":"S Afr Med J"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2009.15.s2.5"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2008.01422.x"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01488805"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.015"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1086\/380488"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-0542(04)90030-9"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199512000-00016"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199611000-00026"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1086\/318157"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00011244"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00098-4"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.15.1837"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200105000-00004"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.6.5.619"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)92346-X"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.99"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.23.3.397"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.6.1273"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.5.986"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051642"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.54.4.1133"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004675200"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.18.3.390"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.17.3.364"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1989.tb00108.x"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.22.8842"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1991.tb02155.x"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1992.tb01422.x"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1995.tb07433.x"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3740"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.10.030"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.02.024"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1993.tb05954.x"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.1995.1.59"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.2.302"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.112"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.10.2282"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1086\/315194"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1086\/338065"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.9.4194-4216.2003"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir052"},{"key":"e_1_3_2_114_2","first-page":"755","article-title":"Interaction of non-lytic b-lactams with penicillin-binding proteins in Streptococcus pneumoniae","volume":"133","author":"Hakenbeck R","year":"1987","unstructured":"Hakenbeck R , Tornette S , Adkinson NF . 1987. Interaction of non-lytic b-lactams with penicillin-binding proteins in Streptococcus pneumoniae . J Gen Microbiol 133:755\u2013760.","journal-title":"J Gen Microbiol"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.4.829"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.2"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.1996.2.183"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.6.1306"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.8.3016-3023.2004"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1089\/107662900419438"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01521.x"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1089\/107662900419401"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2895-2902.2005"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.080067697"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12009"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.23.6798-6805.2000"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.14.5415"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.8.2393-2396.2001"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00184-13"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05340.x"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2009.0891"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119172109"},{"key":"e_1_3_2_133_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12348"},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-121"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.053157-0"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211492200"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.10.3342-3349.1997"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2005.11.9"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01565.x"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trs018"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7054.387"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1086\/374556"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707023170104"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/142.6.923"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1086\/516477"},{"key":"e_1_3_2_146_2","first-page":"131","volume-title":"Colonization of mucosal surfaces","author":"Dowson CG","year":"2005","unstructured":"Dowson CG . 2005. Genetic exchange in the respiratory tract, p 131\u2013140. In Nataro JP , Cohen PS , Mobley HLT , Weiser JN (ed), Colonization of mucosal surfaces, 1st ed. ASM Press, Washington, DC.","edition":"1"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/154.4.1439"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01723.x"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb01089.x"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.4.891"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.97"},{"key":"e_1_3_2_152_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.27.19175"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313492200"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.7.1831-1840.1998"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026082"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis703"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1998.00658.x"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400031879"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.79.2.137"},{"key":"e_1_3_2_160_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.11.3447-3452.2004"},{"key":"e_1_3_2_161_2","doi-asserted-by":"publisher","DOI":"10.1086\/498043"},{"key":"e_1_3_2_162_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030168"},{"key":"e_1_3_2_163_2","doi-asserted-by":"publisher","DOI":"10.1086\/528996"},{"key":"e_1_3_2_164_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1072"},{"key":"e_1_3_2_165_2","doi-asserted-by":"publisher","DOI":"10.1086\/425908"},{"key":"e_1_3_2_166_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001108"},{"key":"e_1_3_2_167_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.3.999-1017.2006"},{"key":"e_1_3_2_168_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf808"},{"key":"e_1_3_2_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.04.006"},{"key":"e_1_3_2_170_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw067"},{"key":"e_1_3_2_171_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.3.577"},{"key":"e_1_3_2_172_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf806"},{"key":"e_1_3_2_173_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2014.0086"},{"key":"e_1_3_2_174_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00781-08"},{"key":"e_1_3_2_175_2","first-page":"129","volume-title":"Abstr 46th Intersci Conf Antimicrob Agents Chemother","author":"Montanari MP","year":"2006","unstructured":"Montanari MP , Giovanetti E , Cochetti I . 2006. An unexpressed tet(M) gene is present in the vast majority of tetracycline-susceptible streptococci carrying erm(B), p 129. Abstr 46th Intersci Conf Antimicrob Agents Chemother."},{"key":"e_1_3_2_176_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.3031-3033.2005"},{"key":"e_1_3_2_177_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.4999-5006.2005"},{"key":"e_1_3_2_178_2","doi-asserted-by":"publisher","DOI":"10.1089\/107662903322286445"},{"key":"e_1_3_2_179_2","doi-asserted-by":"publisher","DOI":"10.1086\/321001"},{"key":"e_1_3_2_180_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00790-07"},{"key":"e_1_3_2_181_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.01.019"},{"key":"e_1_3_2_182_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00019-11"},{"key":"e_1_3_2_183_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02669-13"},{"key":"e_1_3_2_184_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00139-07"},{"key":"e_1_3_2_185_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.06.015"},{"key":"e_1_3_2_186_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.02.002"},{"key":"e_1_3_2_187_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012122"},{"key":"e_1_3_2_188_2","doi-asserted-by":"publisher","DOI":"10.1086\/376642"},{"key":"e_1_3_2_189_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0705.010526"},{"key":"e_1_3_2_190_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.3.553"},{"key":"e_1_3_2_191_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf047"},{"key":"e_1_3_2_192_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0907.020589"},{"key":"e_1_3_2_193_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.12.2760"},{"key":"e_1_3_2_194_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.14.4060-4069.1996"},{"key":"e_1_3_2_195_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.680-688.2002"},{"key":"e_1_3_2_196_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.12.3517-3523.2001"},{"key":"e_1_3_2_197_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1209.051400"},{"key":"e_1_3_2_198_2","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2007.19.6.750"},{"key":"e_1_3_2_199_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.9.1973"},{"key":"e_1_3_2_200_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04858-14"},{"key":"e_1_3_2_201_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.05.022"},{"key":"e_1_3_2_202_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.02.014"},{"key":"e_1_3_2_203_2","doi-asserted-by":"publisher","DOI":"10.1086\/314888"},{"key":"e_1_3_2_204_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.11.2505"},{"key":"e_1_3_2_205_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3187-3194.2003"},{"key":"e_1_3_2_206_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.9.2631-2634.2001"},{"key":"e_1_3_2_207_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.779-780.2005"},{"key":"e_1_3_2_208_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.7.2072-2081.2003"},{"key":"e_1_3_2_209_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3491-3497.2004"},{"key":"e_1_3_2_210_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg465"},{"key":"e_1_3_2_211_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.7.2152-2157.2003"},{"key":"e_1_3_2_212_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2004.10.209"},{"key":"e_1_3_2_213_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-500"},{"key":"e_1_3_2_214_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.149.3.995-1004.1982"},{"key":"e_1_3_2_215_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.12.2891"},{"key":"e_1_3_2_216_2","doi-asserted-by":"publisher","DOI":"10.1006\/plas.1996.0018"},{"key":"e_1_3_2_217_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.11.2979-2984.2000"},{"key":"e_1_3_2_218_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.10.003"},{"key":"e_1_3_2_219_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.5.1208"},{"key":"e_1_3_2_220_2","doi-asserted-by":"publisher","DOI":"10.1089\/10766290152652837"},{"key":"e_1_3_2_221_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00856-10"},{"key":"e_1_3_2_222_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.5.1617-1622.1991"},{"key":"e_1_3_2_223_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.2.393-395.2000"},{"key":"e_1_3_2_224_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00573.x"},{"key":"e_1_3_2_225_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.12.008"},{"key":"e_1_3_2_226_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.11.2406"},{"key":"e_1_3_2_227_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.4.1104-1108.2001"},{"key":"e_1_3_2_228_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.9.4320-4326.1987"},{"key":"e_1_3_2_229_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.10.2121"},{"key":"e_1_3_2_230_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2225"},{"key":"e_1_3_2_231_2","doi-asserted-by":"publisher","DOI":"10.1086\/315382"},{"key":"e_1_3_2_232_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.6.935"},{"key":"e_1_3_2_233_2","doi-asserted-by":"publisher","DOI":"10.1086\/430067"},{"key":"e_1_3_2_234_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01123-09"},{"key":"e_1_3_2_235_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06192.x"},{"key":"e_1_3_2_236_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp231"},{"key":"e_1_3_2_237_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.9.2727-2734.2002"},{"key":"e_1_3_2_238_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg348"},{"key":"e_1_3_2_239_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.8.3169-3171.2004"},{"key":"e_1_3_2_240_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3520-3522.2005"},{"key":"e_1_3_2_241_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3395-3401.2000"},{"key":"e_1_3_2_242_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.11.5800-5803.2005"},{"key":"e_1_3_2_243_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0909.020810"},{"key":"e_1_3_2_244_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01153-06"},{"key":"e_1_3_2_245_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.5024-5032.2005"},{"key":"e_1_3_2_246_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2013.01.025"},{"key":"e_1_3_2_247_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02112-12"},{"key":"e_1_3_2_248_2","doi-asserted-by":"publisher","DOI":"10.1086\/423841"},{"key":"e_1_3_2_249_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3554-3557.2005"},{"key":"e_1_3_2_250_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02630-13"},{"key":"e_1_3_2_251_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.089342.108"},{"key":"e_1_3_2_252_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr200221s"},{"key":"e_1_3_2_253_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp130482"},{"key":"e_1_3_2_254_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.8.2696-2698.2003"},{"key":"e_1_3_2_255_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83050-1"},{"key":"e_1_3_2_256_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.92.6.761"},{"key":"e_1_3_2_257_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.5.365"},{"key":"e_1_3_2_258_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.6.1346"},{"key":"e_1_3_2_259_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1211.060414"},{"key":"e_1_3_2_260_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198545"},{"key":"e_1_3_2_261_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171908"},{"key":"e_1_3_2_262_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003473"},{"key":"e_1_3_2_263_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127912"},{"key":"e_1_3_2_264_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5544"},{"key":"e_1_3_2_265_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2014.994185"},{"key":"e_1_3_2_266_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038271"},{"key":"e_1_3_2_267_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110777"},{"key":"e_1_3_2_268_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31828701ea"},{"key":"e_1_3_2_269_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm839"},{"key":"e_1_3_2_270_2","doi-asserted-by":"publisher","DOI":"10.1054\/drup.2000.0147"},{"key":"e_1_3_2_271_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2319"},{"key":"e_1_3_2_272_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)00005-3"},{"key":"e_1_3_2_273_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01161-06"},{"key":"e_1_3_2_274_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00731-07"},{"key":"e_1_3_2_275_2","doi-asserted-by":"publisher","DOI":"10.1086\/320992"},{"key":"e_1_3_2_276_2","doi-asserted-by":"publisher","DOI":"10.1086\/501367"},{"key":"e_1_3_2_277_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002000"},{"key":"e_1_3_2_278_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.6.1976-1978.2003"},{"key":"e_1_3_2_279_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/152.2.365"},{"key":"e_1_3_2_280_2","doi-asserted-by":"publisher","DOI":"10.1086\/315216"},{"key":"e_1_3_2_281_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200105000-00012"},{"key":"e_1_3_2_282_2","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1105.05045"},{"key":"e_1_3_2_283_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.1.60-70.2003"},{"key":"e_1_3_2_284_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00719-06"},{"key":"e_1_3_2_285_2","doi-asserted-by":"publisher","DOI":"10.1038\/21202"},{"key":"e_1_3_2_286_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00558-06"},{"key":"e_1_3_2_287_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80402-5"},{"key":"e_1_3_2_288_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027333"},{"key":"e_1_3_2_289_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.12.3514-3519.1998"},{"key":"e_1_3_2_290_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.4.853-859.1996"},{"key":"e_1_3_2_291_2","doi-asserted-by":"publisher","DOI":"10.1086\/593339"},{"key":"e_1_3_2_292_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01919-08"},{"key":"e_1_3_2_293_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)71081-3"},{"key":"e_1_3_2_294_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.11.5440-5444.2005"},{"key":"e_1_3_2_295_2","doi-asserted-by":"publisher","DOI":"10.1086\/650496"},{"key":"e_1_3_2_296_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02976-14"},{"key":"e_1_3_2_297_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182788fdd"},{"key":"e_1_3_2_298_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000849"},{"key":"e_1_3_2_299_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir755"},{"key":"e_1_3_2_300_2","doi-asserted-by":"publisher","DOI":"10.1086\/597045"},{"key":"e_1_3_2_301_2","doi-asserted-by":"publisher","DOI":"10.1086\/510249"},{"key":"e_1_3_2_302_2","doi-asserted-by":"publisher","DOI":"10.1086\/528995"},{"key":"e_1_3_2_303_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.03.030"},{"key":"e_1_3_2_304_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035060"},{"key":"e_1_3_2_305_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.05.042"},{"key":"e_1_3_2_306_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.04.074"},{"key":"e_1_3_2_307_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088406"},{"key":"e_1_3_2_308_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.12.013"}],"container-title":["Clinical Microbiology Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CMR.00058-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CMR.00058-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T08:02:22Z","timestamp":1645603342000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CMR.00058-15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":307,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1128\/CMR.00058-15"],"URL":"https:\/\/doi.org\/10.1128\/cmr.00058-15","relation":{},"ISSN":["0893-8512","1098-6618"],"issn-type":[{"value":"0893-8512","type":"print"},{"value":"1098-6618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"2016-04-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}