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This Gram-negative obligate intracellular bacterium, which often causes asymptomatic infection, may cause pelvic inflammatory disease (PID), ectopic pregnancies, scarring of the fallopian tubes, miscarriage, and infertility when left untreated. In the genital tract,\n                    <jats:named-content content-type=\"genus-species\">Chlamydia trachomatis<\/jats:named-content>\n                    infects primarily epithelial cells and requires Th1 immunity for optimal clearance. This review first focuses on the immune cells important in a chlamydial infection. Second, we summarize the research and challenges associated with developing a chlamydial vaccine that elicits a protective Th1-mediated immune response without inducing adverse immunopathologies.\n                  <\/jats:p>","DOI":"10.1128\/cmr.00105-13","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T13:05:34Z","timestamp":1396443934000},"page":"346-370","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":92,"title":["Genital Chlamydia trachomatis: Understanding the Roles of Innate and Adaptive Immunity in Vaccine Research"],"prefix":"10.1128","volume":"27","author":[{"given":"Sam","family":"Vasilevsky","sequence":"first","affiliation":[{"name":"Materno-Fetal &amp; Obstetrics Research Unit, Department of Obstetrics and Gynecology, Lausanne University Hospital (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Greub","sequence":"additional","affiliation":[{"name":"Center for Research on Intracellular Bacteria, Institute of Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Nardelli-Haefliger","sequence":"additional","affiliation":[{"name":"Department of Urology, Lausanne University Hospital (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Baud","sequence":"additional","affiliation":[{"name":"Materno-Fetal &amp; Obstetrics Research Unit, Department of Obstetrics and Gynecology, Lausanne University Hospital (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02647.x"},{"key":"e_1_3_2_3_2","volume-title":"Global incidence and prevalence of selected curable sexually transmitted infections","author":"World Health Organization","year":"2008","unstructured":"World Health Organization. 2008. 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