{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:44:43Z","timestamp":1790642683168,"version":"4.1.0"},"reference-count":158,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0F8316N"],"award-info":[{"award-number":["G0F8316N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0F8316N"],"award-info":[{"award-number":["G0F8316N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["UID 86539"],"award-info":[{"award-number":["UID 86539"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Microbiol Rev"],"published-print":{"date-parts":[[2020,12,16]]},"abstract":"<jats:p>\n                    Successful treatment of tuberculosis (TB) can be hampered by\n                    <jats:named-content content-type=\"genus-species\">Mycobacterium tuberculosis<\/jats:named-content>\n                    populations that are temporarily able to survive antibiotic pressure in the absence of drug resistance-conferring mutations, a phenomenon termed drug tolerance. We summarize findings on\n                    <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n                    tolerance published in the past 20\u2009years. Key\n                    <jats:named-content content-type=\"genus-species\">M. tuberculosis<\/jats:named-content>\n                    responses to drug pressure are reduced growth rates, metabolic shifting, and the promotion of efflux pump activity.\n                  <\/jats:p>","DOI":"10.1128\/cmr.00141-20","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T09:07:42Z","timestamp":1602580062000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":167,"title":["Mechanisms of Drug-Induced Tolerance in Mycobacterium tuberculosis"],"prefix":"10.1128","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-4219","authenticated-orcid":false,"given":"Sander N.","family":"Goossens","sequence":"first","affiliation":[{"name":"Family Medicine and Population Health (FAMPOP), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha L.","family":"Sampson","sequence":"additional","affiliation":[{"name":"DSI\/NRF Centre of Excellence for Biomedical Tuberculosis Research\/SA MRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Van Rie","sequence":"additional","affiliation":[{"name":"Family Medicine and Population Health (FAMPOP), Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Global tuberculosis report 2019","author":"WHO","year":"2019","unstructured":"WHO. 2019. Global tuberculosis report 2019. WHO, Geneva, Switzerland. https:\/\/www.who.int\/tb\/publications\/global_report\/en\/."},{"key":"e_1_3_2_3_2","volume-title":"Global tuberculosis report 2018","author":"WHO","year":"2018","unstructured":"WHO. 2018. Global tuberculosis report 2018. WHO, Geneva, Switzerland. https:\/\/www.who.int\/tb\/publications\/global_report\/en\/."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012918"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199320"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407426"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30274-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.11.2600"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.344.14397"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029588"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medici.2018.01.005"},{"key":"e_1_3_2_12_2","first-page":"644","article-title":"Factors predicting sputum smear conversion and treatment outcomes in new smear-positive pulmonary tuberculosis","volume":"96","author":"Unsematham S","year":"2013","unstructured":"Unsematham S, Kateruttanakul P. 2013. Factors predicting sputum smear conversion and treatment outcomes in new smear-positive pulmonary tuberculosis. J Med Assoc Thai 96:644\u2013649.","journal-title":"J Med Assoc Thai"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03041486"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106075"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/605605"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/10543406.2014.971170"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01876-12"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2016.03.001"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00100-11"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203735109"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7529"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0196-3"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00023-18"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-020518-115650"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.34"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406796200"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00249"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv149"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-012-9348-z"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00295-06"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505446102"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.302588"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052705399"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001065"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5306"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.12.056"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2017-0127"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28711"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01596-17"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt751"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.5575-5580.2000"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9413-4_15"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/fty039"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.02071"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06003-7"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01285-09"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37473-y"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8273"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.022"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02503-17"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00803"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S148444"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098813"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv042"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718003115"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm485"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006077"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704376114"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.182.22.6358-6365.2000"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000037"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.15.5017-5030.2004"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07399.x"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr050248t"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.087817"},{"key":"e_1_3_2_65_2","first-page":"400","article-title":"Streptomycin induced protein expression analysis in Mycobacterium tuberculosis by two-dimensional gel electrophoresis & mass spectrometry","volume":"132","author":"Sharma P","year":"2010","unstructured":"Sharma P, Kumar B, Singhal N, Katoch VM, Venkatesan K, Chauhan DS, Bisht D. 2010. Streptomycin induced protein expression analysis in Mycobacterium tuberculosis by two-dimensional gel electrophoresis & mass spectrometry. Indian J Med Res 132:400\u2013408.","journal-title":"Indian J Med Res"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.10.219"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050075"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505556200"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1994.tb07194.x"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.20.5.666"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2012_279"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1727-6"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03667.x"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3412-3418.2004"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.12.4173-4186.2005"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(03)00648-7"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.19.6603-6611.2005"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.4011"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00239-08"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph5111210"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26902-0"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4163-4170.2004"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800866200"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.4.801-808.1998"},{"key":"e_1_3_2_85_2","first-page":"193","article-title":"Sequential adaptation in latent tuberculosis bacilli: observation by atomic force microscopy (AFM)","volume":"4","author":"Velayati AA","year":"2011","unstructured":"Velayati AA, Farnia P, Masjedi MR, Zhavnerko GK, Merza MA, Ghanavi J, Tabarsi P, Farnia P, Poleschuyk NN, Ignatyev G. 2011. Sequential adaptation in latent tuberculosis bacilli: observation by atomic force microscopy (AFM). Int J Clin Exp Med 4:193\u2013199.","journal-title":"Int J Clin Exp Med"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00711"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.4.1483-1494.2005"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201011-1924OC"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0218-3"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155127"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1907631116"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00663-19"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2005.07.004"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.47.9.2903-2913.2003"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12833"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138253"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.10.2296"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705385114"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.160277"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.708-720.2005"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw6635"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.333385"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229858"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13952"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00724"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01944"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2018.04.005"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06667-3"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317580111"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00687-10"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.33.9.1493"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba9102"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002693"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.MGM2-0023-2013"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.2741\/1293"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00898-06"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61080-0"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907925106"},{"key":"e_1_3_2_119_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks497"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105379108"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201300359"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01270-13"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4369"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.78"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10975-7"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102135"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01462-13"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay3041"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaj2191"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1159\/000226425"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.104.5.737"},{"key":"e_1_3_2_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.10.005"},{"key":"e_1_3_2_133_2","volume-title":"FDA approves new drug for treatment-resistant forms of tuberculosis that affects the lungs","author":"US Food and Drug Administration","year":"2019","unstructured":"US Food and Drug Administration. 2019. FDA approves new drug for treatment-resistant forms of tuberculosis that affects the lungs. US Food and Drug Administration, Silver Spring, MD."},{"key":"e_1_3_2_134_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901814"},{"key":"e_1_3_2_135_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-014-0263-5"},{"key":"e_1_3_2_136_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01577-08"},{"key":"e_1_3_2_137_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2012_300"},{"key":"e_1_3_2_138_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv316"},{"key":"e_1_3_2_139_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02107-17"},{"key":"e_1_3_2_140_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03979-14"},{"key":"e_1_3_2_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.12.031"},{"key":"e_1_3_2_142_2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldw019"},{"key":"e_1_3_2_143_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0490-3"},{"key":"e_1_3_2_144_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1196-0"},{"key":"e_1_3_2_145_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep17507"},{"key":"e_1_3_2_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.08.010"},{"key":"e_1_3_2_147_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02266-17"},{"key":"e_1_3_2_148_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01213-19"},{"key":"e_1_3_2_149_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3530"},{"key":"e_1_3_2_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2018.10.009"},{"key":"e_1_3_2_151_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003419"},{"key":"e_1_3_2_152_2","first-page":"3036","article-title":"Genome-wide DNA methylation and transcriptome changes in Mycobacterium tuberculosis with rifampicin and isoniazid resistance","volume":"11","author":"Chen L","year":"2018","unstructured":"Chen L, Li HC, Chen T, Yu L, Guo HX, Chen YH, Chen M, Li ZY, Wu ZH, Wang XZ, Zhao J, Yan HM, Wang XC, Zhou L, Zhou J. 2018. Genome-wide DNA methylation and transcriptome changes in Mycobacterium tuberculosis with rifampicin and isoniazid resistance. Int J Clin Exp Pathol 11:3036\u20133045.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_2_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2017.09.013"},{"key":"e_1_3_2_154_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929866522666150209113708"},{"key":"e_1_3_2_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.022"},{"key":"e_1_3_2_156_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030087"},{"key":"e_1_3_2_157_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13227"},{"key":"e_1_3_2_158_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06003-11"},{"key":"e_1_3_2_159_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119013"}],"container-title":["Clinical Microbiology Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CMR.00141-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/CMR.00141-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T08:23:54Z","timestamp":1645604634000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/CMR.00141-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,16]]},"references-count":158,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12,16]]}},"alternative-id":["10.1128\/CMR.00141-20"],"URL":"https:\/\/doi.org\/10.1128\/cmr.00141-20","relation":{},"ISSN":["0893-8512","1098-6618"],"issn-type":[{"value":"0893-8512","type":"print"},{"value":"1098-6618","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,16]]},"assertion":[{"value":"2020-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00141-20"}}