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However, symptomatic disease can take decades to become apparent, and there is a broad spectrum of possible outcomes. The complex and long-term nature of this infection places a major constraint on the scope for experimental studies in humans. Accordingly, predictive animal models have been a mainstay of Chagas disease research. The resulting data have made major contributions to our understanding of parasite biology, immune responses, and disease pathogenesis and have provided a platform that informs and facilitates the global drug discovery effort. Here, we provide an overview of available animal models and illustrate how they have had a key impact across the field.\n          <\/jats:p>","DOI":"10.1128\/cmr.00155-23","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T14:00:21Z","timestamp":1731679221000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Animal models for exploring Chagas disease pathogenesis and supporting drug discovery"],"prefix":"10.1128","volume":"37","author":[{"given":"Archie A.","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Infection Biology, London School of Hygiene and Tropical Medicine","place":["London, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin C.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Infection Biology, London School of Hygiene and Tropical Medicine","place":["London, 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