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An estimated 2 billion people worldwide are infected with\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    (Mtb), and 5\u201310% of those with latent infection will develop active TB. Despite the success of existing anti-TB drugs in controlling transmission, significant challenges remain, including long treatment durations, severe side effects, suboptimal treatment adherence, and inevitable drug resistance. Even newly developed drugs may fail to keep pace with the rising number of drug-resistant cases. Moreover, these treatments do not adequately address persistent lung dysfunction after cure. A primary reason for these therapeutic challenges in TB management may be that all current anti-TB drugs are solely aimed at achieving antibacterial, bacteriostatic, or bactericidal efficacy, which neglects the critical role of host cellular responses during disease progression. Future strategies should explore the potential of cell-based therapies, an area that has received limited attention in previous reviews. From the perspective of cell therapy, this article comprehensively reviews key clinical studies, animal models, and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    experiments from recent decades that utilized cells or cytokines for TB treatment, providing clinicians and researchers with a unique perspective and support for developing more integrated therapeutic strategies toward ending TB.\n                  <\/jats:p>","DOI":"10.1128\/cmr.00232-25","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:00:40Z","timestamp":1765807240000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive review and reflective evaluation of cell therapies for tuberculosis"],"prefix":"10.1128","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7732-1170","authenticated-orcid":true,"given":"Lan","family":"Zhao","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ybmxt82","id-type":"ROR","asserted-by":"publisher"}],"name":"Guangzhou National Laboratory","place":["Guangzhou, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/02vg7mz57","id-type":"ROR","asserted-by":"publisher"}],"name":"State Key Laboratory of Respiratory Disease, Institute of Tuberculosis, Guangzhou Medical University, Institute of Pulmonary Disease, Guangzhou Chest Hospital Affiliated to Guangdong Pharmaceutical University","place":["Guangzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ybmxt82","id-type":"ROR","asserted-by":"publisher"}],"name":"Guangzhou National Laboratory","place":["Guangzhou, People's Republic of China"]},{"id":[{"id":"https:\/\/ror.org\/04kx2sy84","id-type":"ROR","asserted-by":"publisher"}],"name":"Key Laboratory of Pathogenic Fungi and Mycotoxins of Fujian Province, and School of Life Sciences, Fujian Agriculture and Forestry University","place":["Fuzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ybmxt82","id-type":"ROR","asserted-by":"publisher"}],"name":"Guangzhou National Laboratory","place":["Guangzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3502-7957","authenticated-orcid":false,"given":"Beibei","family":"Ni","sequence":"additional","affiliation":[{"name":"Vaccine Research Institute, Cell-Gene Therapy Translational Medicine Research Centre, The Third Affiliated Hospital of Sun Yat-sen University","place":["Guangzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8134-094X","authenticated-orcid":false,"given":"Lijun","family":"Bi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03ybmxt82","id-type":"ROR","asserted-by":"publisher"}],"name":"Guangzhou National Laboratory","place":["Guangzhou, People's Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62173-3"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00323-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.12.005"},{"key":"e_1_3_3_5_2","first-page":"889","article-title":"Update on latent tuberculosis infection","volume":"89","author":"Hartman-Adams H","year":"2014","unstructured":"Hartman-Adams H, Clark K, Juckett G. 2014. 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