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In the absence of head-to-head clinical trials and availability of all potential options on a global basis, we have systematically analyzed potential antibiotics for carbapenem-resistant\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    . Monotherapy with ceftazidime-avibactam, imipenem-cilastatin-relebactam, cefiderocol, or high doses of ceftolozane-tazobactam is generally considered an acceptable option for serious infections due to carbapenem-resistant\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    . The role of testing combinations of antimicrobial agents for\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    susceptibility is uncertain, as is the administration of nebulized colistin or amikacin in patients with ventilator-associated pneumonia. With regard to new therapies, 10 clinical trials are underway or have been completed on bacteriophage therapy for\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    infections. However, no phage options are yet widely approved for use. Other new options in clinical trials include beta-lactam antibiotics combined with new beta-lactamase inhibitors and antibody-based therapies.\n                  <\/jats:p>","DOI":"10.1128\/cmr.00233-24","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:00:55Z","timestamp":1760014855000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Current and future options for the treatment of serious infections due to carbapenem-resistant\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1128","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9873-5459","authenticated-orcid":false,"given":"Juan P.","family":"Horcajada","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03a8gac78","id-type":"ROR","asserted-by":"publisher"}],"name":"Infectious Diseases Service, Hospital del Mar Research Institute (IMIM), Universitat Pompeu Fabra 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