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Since 1990, new vaccines have become available to prevent five infectious diseases: varicella, rotavirus, hepatitis A, Lyme disease, and Japanese encephalitis virus infection. Improved vaccines have been developed to prevent Haemophilus influenzae type b, pneumococcus, pertussis, rabies, and typhoid infections. Immunization strategies for the prevention of hepatitis B, measles, meningococcal infections, and poliomyelitis have changed as a result of the changing epidemiology of these diseases. Combination vaccines are being developed to facilitate the delivery of multiple antigens, and improved vaccines are under development for cholera, influenza, and meningococcal disease. Major advances in molecular biology have enabled scientists to devise new approaches to the development of vaccines against diseases ranging from respiratory viral to enteric bacterial infections that continue to plague the world's population.<\/jats:p><\/jats:sec>","DOI":"10.1128\/cmr.14.4.872-908.2001","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:55:30Z","timestamp":1027749330000},"page":"872-908","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Active Immunization in the United States: Developments over the Past Decade"],"prefix":"10.1128","volume":"14","author":[{"given":"Penelope H.","family":"Dennehy","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Pediatric Infectious Diseases, Rhode Island Hospital, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/314951"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.1.26"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03440090052025"},{"key":"e_1_3_1_5_2","unstructured":"American Academy of Pediatrics Arboviruses 2000 Red Book: Report of the Committee on Infectious Diseases 24th ed. 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