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A serogroup A\/C\/W-135\/Y polysaccharide meningococcal vaccine has been licensed in the United States since 1981 but has not been used universally outside of the military. On 14 January 2005, a polysaccharide conjugate vaccine that covers meningococcal serogroups A, C, W-135, and Y was licensed in the United States for 11- to 55-year-olds and is now recommended for the routine immunization of adolescents and other high-risk groups. This review covers the changing epidemiology of meningococcal disease in the United States, issues related to vaccine prevention, and recommendations on the use of the new vaccine.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/cmr.19.1.142-164.2006","type":"journal-article","created":{"date-parts":[[2006,1,17]],"date-time":"2006-01-17T17:41:01Z","timestamp":1137519661000},"page":"142-164","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":132,"title":["Prospects for Vaccine Prevention of Meningococcal Infection"],"prefix":"10.1128","volume":"19","author":[{"given":"Lee H.","family":"Harrison","sequence":"first","affiliation":[{"name":"Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050935"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0703.017309"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03500020055031"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0808.010422"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/319995"},{"key":"e_1_3_2_7_2","first-page":"317","volume":"61","year":"1983","unstructured":"Ambrosch, F., G. 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