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Clinical manifestations separate the disease into stages; late stages of disease are now uncommon compared to the preantibiotic era.\n                      <jats:italic>T. pallidum<\/jats:italic>\n                      has an unusually small genome and lacks genes that encode many metabolic functions and classical virulence factors. The organism is extremely sensitive to environmental conditions and has not been continuously cultivated in vitro. Nonetheless,\n                      <jats:italic>T. pallidum<\/jats:italic>\n                      is highly infectious and survives for decades in the untreated host. Early syphilis lesions result from the host's immune response to the treponemes. Bacterial clearance and resolution of early lesions results from a delayed hypersensitivity response, although some organisms escape to cause persistent infection. One factor contributing to\n                      <jats:italic>T. pallidum<\/jats:italic>\n                      's chronicity is the paucity of integral outer membrane proteins, rendering intact organisms virtually invisible to the immune system. Antigenic variation of TprK, a putative surface-exposed protein, is likely to contribute to immune evasion.\n                      <jats:italic>T. pallidum<\/jats:italic>\n                      remains exquisitely sensitive to penicillin, but macrolide resistance has recently been identified in a number of geographic regions. The development of a syphilis vaccine, thus far elusive, would have a significant positive impact on global health.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/cmr.19.1.29-49.2006","type":"journal-article","created":{"date-parts":[[2006,1,17]],"date-time":"2006-01-17T17:41:01Z","timestamp":1137519661000},"page":"29-49","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":526,"title":["Biological Basis for Syphilis"],"prefix":"10.1128","volume":"19","author":[{"given":"Rebecca E.","family":"LaFond","sequence":"first","affiliation":[{"name":"Departments of Pathobiology"},{"name":"Medicine, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila A.","family":"Lukehart","sequence":"additional","affiliation":[{"name":"Departments of Pathobiology"},{"name":"Medicine, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","first-page":"66","volume":"11","year":"1990","unstructured":"Abdul Gaffoor, P. 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