{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:19:52Z","timestamp":1789849192428,"version":"4.0.1"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin. Vaccine Immunol."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Whereas patients with multiple myeloma (MM) have a well-documented susceptibility to infections, this has been less studied in other B-cell disorders, such as Waldenstrom's macroglobulinemia (WM) and monoclonal gammopathy of undetermined significance (MGUS). We investigated the humoral immunity to 24 different pathogens in elderly patients with MM (<jats:italic>n<\/jats:italic>= 25), WM (<jats:italic>n<\/jats:italic>= 16), and MGUS (<jats:italic>n<\/jats:italic>= 18) and in age-matched controls (<jats:italic>n<\/jats:italic>= 20). Antibody titers against pneumococci, staphylococcal alpha-toxin, tetanus and diphtheria toxoids, and varicella, mumps, and rubella viruses were most depressed in MM patients, next to lowest in WM and MGUS patients, and highest in the controls. In contrast, levels of antibodies specific for staphylococcal teichoic acid,<jats:named-content content-type=\"genus-species\">Moraxella catarrhalis<\/jats:named-content>, candida, aspergillus, and measles virus were similarly decreased in MM and MGUS patients. Comparable titers in all study groups were seen against<jats:named-content content-type=\"genus-species\">Haemophilus influenzae<\/jats:named-content>type b (Hib), borrelia, toxoplasma, and members of the herpesvirus family. Finally, a uniform lack of antibodies was noted against<jats:named-content content-type=\"genus-species\">Streptococcus pyogenes<\/jats:named-content>, salmonella, yersinia, brucella, francisella, and herpes simplex virus type 2. To conclude, although MM patients displayed the most depressed humoral immunity, significantly decreased antibody levels were also evident in patients with WM and MGUS, particularly against<jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>, pneumococci, and varicella. Conversely, immunity was retained for Hib and certain herpesviruses in all study groups.<\/jats:p>","DOI":"10.1128\/cvi.00021-11","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T00:16:16Z","timestamp":1303344976000},"page":"969-977","source":"Crossref","is-referenced-by-count":62,"title":["Comparative Study of Immune Status to Infectious Agents in Elderly Patients with Multiple Myeloma, Waldenstrom's Macroglobulinemia, and Monoclonal Gammopathy of Undetermined Significance"],"prefix":"10.1128","volume":"18","author":[{"given":"Johanna","family":"Karlsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Andr\u00e9asson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Kondori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Erman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Riesbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Hogevik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wenner\u00e5s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","published-online":{"date-parts":[[2011,4,20]]},"reference":[{"key":"key20180919073518_B1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1055\/s-2006-945530","article-title":"Major complications following hematopoietic stem cell transplantation","volume":"27","author":"Afessa","year":"2006","journal-title":"Semin. 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