{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:42:13Z","timestamp":1791384133256,"version":"4.3.3"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Stanford Child Health Research Institute and NIH-NCATS-CTSA","award":["UL1 TR001085"],"award-info":[{"award-number":["UL1 TR001085"]}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1066865"],"award-info":[{"award-number":["OPP1066865"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Many factors can influence maternal placental antibody transfer to the fetus, which confers important immune protection to the newborn infant. However, little is known about the effect of maternal parasitic infection on placental antibody transfer. To investigate this, we selected from a parent study of 576 pregnant Kenyan women four groups of women with term deliveries (\u226537 weeks), including uninfected women (\n            <jats:italic>n<\/jats:italic>\n            = 30) and women with solo infections with malaria (\n            <jats:italic>n<\/jats:italic>\n            = 30), hookworm (\n            <jats:italic>n<\/jats:italic>\n            = 30), or schistosomiasis (\n            <jats:italic>n<\/jats:italic>\n            = 10). Maternal plasma at delivery and infant cord blood were tested via multiplex fluorescent bead assay for IgG against 10 pneumococcal serotypes (PnPs 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, and 23F), diphtheria toxoid, and\n            <jats:named-content content-type=\"genus-species\">Haemophilus influenzae<\/jats:named-content>\n            type B. Infants born to mothers with prenatal malaria, hookworm, or\n            <jats:named-content content-type=\"genus-species\">Schistosoma haematobium<\/jats:named-content>\n            infections were associated with a significantly reduced ratio of maternal to infant cord blood antibody concentration for\n            <jats:named-content content-type=\"genus-species\">Streptococcus pneumoniae<\/jats:named-content>\n            serotypes 1, 4, 5, 6B, 7F, 9V, and 18C compared to infants of uninfected mothers. Anti-diphtheria toxoid and anti-\n            <jats:named-content content-type=\"genus-species\">H. influenzae<\/jats:named-content>\n            type B IgG ratios were not significantly different among infection groups. Prenatal parasitic infections decrease the transfer of maternal IgG antibodies to infants for several serotypes of\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/cvi.00039-17","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:40:16Z","timestamp":1492044016000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Parasitic Infections in Pregnancy Decrease Placental Transfer of Antipneumococcus Antibodies"],"prefix":"10.1128","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6277-2733","authenticated-orcid":false,"given":"Noah D.","family":"McKittrick","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Vu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Lucille Packard Children's Hospital at Stanford School of Medicine, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"King","sequence":"additional","affiliation":[{"name":"Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Mutuku","sequence":"additional","affiliation":[{"name":"Department of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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