{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:36:19Z","timestamp":1790487379499,"version":"4.1.0"},"reference-count":10,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Possible smallpox reemergence drives research for third-generation vaccines that effectively neutralize variola virus. A comparison of neutralization assays using different substrates, variola and vaccinia (Dryvax and modified vaccinia Ankara [MVA]), showed significantly different 90% neutralization titers; Dryvax underestimated while MVA overestimated variola neutralization. Third-generation vaccines may rely upon neutralization as a correlate of protection.<\/jats:p>","DOI":"10.1128\/cvi.00056-12","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T09:52:57Z","timestamp":1337248377000},"page":"1116-1118","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Analysis of Variola and Vaccinia Virus Neutralization Assays for Smallpox Vaccines"],"prefix":"10.1128","volume":"19","author":[{"given":"Christine M.","family":"Hughes","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances K.","family":"Newman","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine, Division of Infectious Diseases and Immunology, Edward A. Doisy Research Center, Saint Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitni B.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria A.","family":"Olson","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott K.","family":"Smith","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Holman","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihan","family":"Yan","sequence":"additional","affiliation":[{"name":"The EMMES Corporation, Rockville, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon E.","family":"Frey","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine, Division of Infectious Diseases and Immunology, Edward A. 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An Investigation of immunological relationships between the viruses of variola, vaccinia, cowpox and ectromelia by neutralization tests on the chorio-allantois of chick embryos. Br. J. Exp. Pathol. 29: 501\u2013510.","journal-title":"Br. J. Exp. 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