{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T09:00:55Z","timestamp":1649149255676},"reference-count":17,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.<\/jats:p>","DOI":"10.1128\/cvi.00071-09","type":"journal-article","created":{"date-parts":[[2009,4,23]],"date-time":"2009-04-23T00:55:42Z","timestamp":1240448142000},"page":"953-955","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis"],"prefix":"10.1128","volume":"16","author":[{"given":"Camila R.","family":"Cacere","sequence":"first","affiliation":[{"name":"Laboratory of Dermatology and Immunodeficiencies, Medical School of the University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil"},{"name":"Clinical Pathology Department, Faculty of Pharmaceutical Sciences, Sa\u0303o Paulo State University, Araraquara, Sa\u0303o Paulo, Brazil"},{"name":"Instituto de Pesquisa Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil"},{"name":"Systemic Mycoses Outpatient Unit, Division of Infectious Diseases, Clinics Hospital, Medical School of the University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J. S.","family":"Mendes-Giannini","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology and Immunodeficiencies, Medical School of the University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil"},{"name":"Clinical Pathology Department, Faculty of Pharmaceutical Sciences, Sa\u0303o Paulo State University, Araraquara, Sa\u0303o Paulo, Brazil"},{"name":"Instituto de Pesquisa Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil"},{"name":"Systemic Mycoses Outpatient Unit, Division of Infectious Diseases, Clinics Hospital, Medical School of the University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Carlos F.","family":"do Valle","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology and Immunodeficiencies, Medical School of the University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil"},{"name":"Clinical Pathology Department, Faculty of Pharmaceutical Sciences, Sa\u0303o Paulo State University, Araraquara, Sa\u0303o Paulo, Brazil"},{"name":"Instituto de Pesquisa Evandro Chagas, Fiocruz, Rio de Janeiro, Brazil"},{"name":"Systemic Mycoses Outpatient Unit, Division of Infectious Diseases, Clinics Hospital, Medical School of the University of Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto J. 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