{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:32:29Z","timestamp":1774121549784,"version":"3.50.1"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Screening for latent tuberculosis infection (LTBI) with the Mantoux tuberculin skin test (TST) has many limitations including false-positive results due to\n            <jats:italic>Mycobacterium bovis<\/jats:italic>\n            bacillus Calmette-Gue\u0301rin (BCG) vaccination. Three hundred ninety adult inmates with normal screening chest radiographs in a county jail were evaluated for LTBI using TST and an ESAT-6\/CFP-10 peptide-based enzyme-linked immunospot assay (T-SPOT.\n            <jats:italic>TB<\/jats:italic>\n            ). LTBI prevalence rates were 19.0% and 8.5% by T-SPOT.\n            <jats:italic>TB<\/jats:italic>\n            and TST, respectively. Overall agreement between test results was 82.8% (\u03ba = 0.29). Positive T-SPOT.\n            <jats:italic>TB<\/jats:italic>\n            results were significantly associated with increased age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01 to 1.06) and intravenous drug use history (OR, 2.92; 95% CI, 1.36 to 6.27). Positive TST results were significantly associated with increased age (OR, 1.06; 95% CI, 1.02 to 1.09) and foreign birth (OR, 6.61; 95% CI, 1.98 to 22.01). Discordant covariates between the assay results included increased age (OR, 0.96; 95% CI, 0.94 to 0.99) and intravenous drug use history (OR, 0.41; 95% CI, 0.19 to 0.88). T-SPOT.\n            <jats:italic>TB<\/jats:italic>\n            reactivity is unaffected by prior BCG vaccination. T-SPOT.\n            <jats:italic>TB<\/jats:italic>\n            may be more sensitive than TST in diagnosing LTBI among a moderate risk population of inmates, particularly those with intravenous drug use history. Longitudinal studies are needed to assess the positive predictive value of T-SPOT.\n            <jats:italic>TB<\/jats:italic>\n            in identifying those most likely to convert to active disease in general populations as well as in high-risk subpopulations.\n          <\/jats:p>","DOI":"10.1128\/cvi.00073-07","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T00:59:08Z","timestamp":1176944348000},"page":"714-719","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Comparison of an ESAT-6\/CFP-10 Peptide-Based Enzyme-Linked Immunospot Assay to a Tuberculin Skin Test for Screening of a Population at Moderate Risk of Contracting Tuberculosis"],"prefix":"10.1128","volume":"14","author":[{"given":"Esmaeil","family":"Porsa","sequence":"first","affiliation":[{"name":"Department of Family and Community Medicine, The University of Texas Health Science Center, Houston, Texas"},{"name":"Center for Clinical Epidemiology and Evidence Based Medicine, The University of Texas Health Science Center, Houston, Texas"},{"name":"Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, The University of Texas Health Science Center, Houston, Texas"},{"name":"Center for Clinical Epidemiology and Evidence Based Medicine, The University of Texas Health Science Center, Houston, Texas"},{"name":"Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward A.","family":"Graviss","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, The University of Texas Health Science Center, Houston, Texas"},{"name":"Center for Clinical Epidemiology and Evidence Based Medicine, The University of Texas Health Science Center, Houston, Texas"},{"name":"Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1164\/ajrccm.161.4.16141","volume":"161","year":"2000","unstructured":"American Thoracic Society. 2000. Diagnostic standards and classification of tuberculosis in adults and children. Am. J. Respir. Crit. Care Med.161:1376-1395.","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"S221","DOI":"10.1164\/ajrccm.161.supplement_3.ats600","volume":"161","year":"2000","unstructured":"American Thoracic Society\/Centers for Disease Control and Prevention. 2000. Targeted tuberculin testing and treatment of latent tuberculosis infection. Joint Statement of the American Thoracic Society (ATS) and the Centers for Disease Control and Prevention (CDC). Am. J. Respir. Crit. Care Med.161:S221-S247.","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"e_1_3_2_4_2","first-page":"S417","volume":"7","year":"2003","unstructured":"Bur, S., J. E. Golub, J. A. Armstrong, K. Myers, B. H. Johnson, D. Mazo, et al. 2003. Evaluation of an extensive contact investigation in an urban community and jail. Int. J. Tuberc. 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