{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:04:12Z","timestamp":1722931452376},"reference-count":22,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The antibody response to capsular polysaccharides of pneumococcal serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F elicited either naturally or after vaccination with Prevenar was investigated in a cohort of children (\n            <jats:italic>n<\/jats:italic>\n            = 163) with underlying chronic or recurrent lung diseases at risk of developing pneumococcal pneumonia and ultimately invasive disease. Serum concentrations of serotype-specific antibodies, as measured by enzyme-linked immunosorbent assay, in unvaccinated children (\n            <jats:italic>n<\/jats:italic>\n            = 88) were higher in nasopharyngeal carriers (\n            <jats:italic>n<\/jats:italic>\n            = 10) than in noncarriers (\n            <jats:italic>n<\/jats:italic>\n            = 78) both at baseline and during follow-up. However, the antibody levels depended on the serotype and age of the children. During the study period, 35% of unvaccinated noncarriers and 60% of unvaccinated carriers displayed serum antibodies to all serotypes above the reported WHO working group putative protective serum concentration against invasive disease (0.2 \u03bcg\/ml). Overall, children vaccinated with Prevenar before enrollment (\n            <jats:italic>n<\/jats:italic>\n            = 61), irrespective of their carrier status, displayed significantly higher serum levels of antibodies to all serotypes than unvaccinated children. More than 85% of the vaccinated children had protective serum antibody concentrations at baseline; although antibody titers tended to decrease over time, the above-mentioned figure remained without change at the end of follow-up. The vaccine Prevenar elicited a significant rise in serum antibody concentrations against all serotypes in 14 children vaccinated at entry. All of these children acquired and maintained serum antibody levels of &gt;0.2 \u03bcg\/ml throughout the study (a mean of 13 months of follow-up). These data support the systematic use of the vaccine Prevenar in children with underlying chronic or recurrent lung diseases and stress the fact that a percentage of vaccinated children may need to be revaccinated in order to achieve protection against pneumococcal disease.\n          <\/jats:p>","DOI":"10.1128\/cvi.00079-06","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T17:07:13Z","timestamp":1149700033000},"page":"665-670","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Type-Specific Antibodies to Pneumococcal Capsular Polysaccharide Acquired either Naturally or after Vaccination with Prevenar in Children with Underlying Chronic or Recurrent Lung Diseases"],"prefix":"10.1128","volume":"13","author":[{"given":"David","family":"Navarro","sequence":"first","affiliation":[{"name":"Department of Microbiology, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Unit of Pneumology, Department of Pediatrics, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Obstetrics, Gynecology, and Pediatrics, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Instituto Valenciano de Microbiologi\u0301a, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo","family":"Escribano","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Unit of Pneumology, Department of Pediatrics, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Obstetrics, Gynecology, and Pediatrics, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Instituto Valenciano de Microbiologi\u0301a, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cebria\u0301n","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Unit of Pneumology, Department of Pediatrics, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Obstetrics, Gynecology, and Pediatrics, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Instituto Valenciano de Microbiologi\u0301a, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepcio\u0301n","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Unit of Pneumology, Department of Pediatrics, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Obstetrics, Gynecology, and Pediatrics, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Instituto Valenciano de Microbiologi\u0301a, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Garci\u0301a-Maset","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Unit of Pneumology, Department of Pediatrics, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Obstetrics, Gynecology, and Pediatrics, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Instituto Valenciano de Microbiologi\u0301a, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Garci\u0301a-de-Lomas","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Unit of Pneumology, Department of Pediatrics, University Clinical Hospital, Valencia, Spain"},{"name":"Department of Obstetrics, Gynecology, and Pediatrics, School of Medicine, University of Valencia, Valencia, Spain"},{"name":"Instituto Valenciano de Microbiologi\u0301a, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Spanish Pneumococcal Infection Study Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200003000-00003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"S797","DOI":"10.1093\/clinids\/5.Supplement_4.S797","volume":"5","year":"1983","unstructured":"Brown, E. 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