{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:04:37Z","timestamp":1791072277485,"version":"4.1.0"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Clin Vaccine Immunol"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Serological testing to detect toxoplasmosis is of major importance to avoid the possible effects of the disease in newborns. This study assessed anti-\n            <jats:named-content content-type=\"genus-species\">Toxoplasma<\/jats:named-content>\n            IgG and IgM with the Vidas (bioM\u00e9rieux), Architect (Abbott), and Liaison (DiaSorin) systems in 631 sera from pregnant women and newborns as well as anti-\n            <jats:named-content content-type=\"genus-species\">Toxoplasma<\/jats:named-content>\n            IgG avidity with these three systems on 54 sera from pregnant women with positive IgG and IgM. The IgG and IgM results were in agreement in, respectively, 95.2% and 98.3% (Vidas versus Architect) and 96.9% and 95.3% (Vidas versus Liaison) of the samples. Specificities were excellent for all the assays, while Vidas sensitivities ranged (depending on the classification of gray zone results) from 93.8 to 98.4% for IgG (Architect, 84.4 to 93.8%; Liaison, 93.8%) and from 81.8 to 90.9% for IgM (Architect, 63.6%; Liaison, 81.8 to 90.9%). In seroconversion sequences, IgMs were generally detected simultaneously by the three assays, while Architect was the earliest assay to detect IgG. In noninfected children, maternally transmitted IgGs were detected for a longer time with Architect than with the other systems. IgMs were positive in only one infected child with the Vidas and Liaison systems. Significantly more sera were classified in the high-avidity category with Vidas than with Architect. This evaluation shows similar performances for Vidas and more recent systems. The Vidas system adequately detects toxoplasmosis in pregnant women and newborns. This system fits the needs of laboratories working on small routine series for first-line testing as well as expert laboratories, due to a high specificity and a powerful avidity test.\n          <\/jats:p>","DOI":"10.1128\/cvi.00089-13","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T03:57:28Z","timestamp":1370491048000},"page":"1203-1212","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Comparison of the Vidas System and Two Recent Fully Automated Assays for Diagnosis and Follow-Up of Toxoplasmosis in Pregnant Women and Newborns"],"prefix":"10.1128","volume":"20","author":[{"given":"Jean-Benjamin","family":"Murat","sequence":"first","affiliation":[{"name":"Laboratory of Parasitology and Mycology, Grenoble University Hospital, Grenoble, France"},{"name":"UMR 5163 CNRS\u2014Joseph Fourier University Grenoble I, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Dard","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Mycology, Grenoble University Hospital, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Fricker Hidalgo","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Mycology, Grenoble University Hospital, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Dard\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Mycology, National Reference Center and Biological Resource Center for Toxoplasmosis, CHU Dupuytren, Limoges, France"},{"name":"UMR 1094 INSERM, Faculty of Medicine, University of Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Brenier-Pinchart","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Mycology, Grenoble University Hospital, Grenoble, France"},{"name":"UMR 5163 CNRS\u2014Joseph Fourier University Grenoble I, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Pelloux","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology and Mycology, Grenoble University Hospital, Grenoble, France"},{"name":"UMR 5163 CNRS\u2014Joseph Fourier University Grenoble I, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.02.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"VillenaI\nAncelleT\nDelmasC\nGarciaP\nBrezinAP\nThulliezP\nWallonM\nKingL\nGouletV. 2010. \nCongenital toxoplasmosis in France in 2007: first results from a national surveillance system. \nEuro Surveill. 15:pii=19600. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=19600.","DOI":"10.2807\/ese.15.25.19600-en"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/09273948.2011.564068","article-title":"Clinical manifestations of ocular toxoplasmosis","volume":"19","author":"Delair E","year":"2011","unstructured":"DelairE LatkanyP NobleAG RabiahP McLeodR Br\u00e9zinA. 2011. 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